Protein Alignment SLC6A2 and CG8850

DIOPT Version :9

• Sequence 1: NP_001165975.1
• Gene: SLC6A2 / 6530
• HGNCID: 11048
• Length: 628
• Species: Homo sapiens
• Sequence 2: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 606
• Identity: 202/606 - (33%)
• Similarity: 325/606 - (53%)
• Gaps: 43/606 - (7%)

Human    40 NGVQCLLAPRDGD------------AQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGG 92
            :|:..::...:|:            :..|:.|.:.::||.|.:..:|.|.||||||::..:||||
  Fly    29 DGISTVIYSAEGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGG 93

Human    93 AFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIA 157
            ||||||.:.|::.|.|::|:|:.:||::..|....:.:.|..:|:.|..:........||..|:|
  Fly    94 AFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTYYACIMA 158

Human   158 WSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAE-FYERGVLHL 221
            .::.||.:||:..||||.|...|.. :|    :..|:...|.:  |..:...:|| |:.:.||..
  Fly   159 LTIRYLVASFSEVLPWTYCLVEWGK-SC----VATGATAANDS--SIVQGVSSAELFFTQTVLRE 216

Human   222 HESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPG 286
            .||...:.:|.|.|.|:|||:...:::...|.||:::|||..:..|..||.::.|||:..|||||
  Fly   217 PESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPG 281

Human   287 ASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINC 351
            |..||..:|...:.:|....||..|.||:||||...||.|:.:||:|.|:.|.::|.::.::|:.
  Fly   282 AWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDS 346

Human   352 ITSFVSGFAIFSILGYMAHE-HKVNIEDVATEGAGLVFILYPEAISTLSG-STFWAVVFFVMLLA 414
            :||.::|..||.|||.:|.| :..:|..|...||||.||.|||||:.... ...:||:||.|||.
  Fly   347 LTSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLV 411

Human   415 LGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGT 479
            ||:.|::|...||:..:.|.|..|...  |.....:...||..|..:|.||.:||.|:|.:....
  Fly   412 LGIGSNIGMASAVVNVVKDRFTHLPHW--LLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTF 474

Human   480 SILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLT 544
            ..|...:.|.:.|.|.|||.|..:||:.|:..:...|||:||..|:|..:..|:|..:.:::|||
  Fly   475 IALVLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLT 539

Human   545 YDDYIFPP---WANWVGWGIALSSMVLVPIYVIY---------KF-LSTQGSL-WERLAYGITPE 595
            |....:||   .|.|:.||:.:..:....:..||         || |:.|.:. |..|.   |.:
  Fly   540 YRGVQYPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPGKTFGSKFGLAMQPTANWGPLQ---TQK 601

Human   596 NEHHLVAQRDIRQFQMKTRQG 616
            .|.:::.::  |:...|:.:|
  Fly   602 FEAYIIHRK--READFKSPRG 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A2	NP_001165975.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		SLC6sbd_NET	56..612	CDD:212081	198/572 (35%)
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	176/482 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820