Protein Alignment SLC6A2 and ine

DIOPT Version :10

• Sequence 1: NP_001165975.1
• Gene: SLC6A2 / 6530
• HGNCID: 11048
• Length: 628
• Species: Homo sapiens
• Sequence 2: NP_477012.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Alignment Length: 616
• Identity: 236/616 - (38%)
• Similarity: 354/616 - (57%)
• Gaps: 48/616 - (7%)

Human     2 LLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRET-WGKKIDF 65
            |...:|||..|. .|.|........:.:||:|                    :||:. |..|:.|
  Fly   303 LFDMVNPQTPPP-LGVDDDDSYLDMSDETAQL--------------------KPRQQHWANKMQF 346

Human    66 LLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREG-AATVWK 129
            :|:.:|::|.|.|||||||:|||:|||.||:||.:.|.|..:||.:|||::|||...| ...:.:
  Fly   347 VLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQ 411

Human   130 ICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDP--KLLN 192
            :||.|||.|.|.::::..:..||:|||.:|:||.|:||...:||.||.:.||:|:|..|  |.:|
  Fly   412 LCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRKGIN 476

Human   193 GSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVK 257
            .|......       ||:.||:|..||.:  |.|:...|:.:|:|..||:...:::||:.||.:|
  Fly   477 ASAPDTSR-------TPSEEFFENKVLQI--SGGLEYPGMMRWELFACLICAWLMVYFATWKSIK 532

Human   258 TSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAG 322
            :|.||.:.|||.|:.::.:|:|..|||.||:.|:..:....:..||.|.|||:||:|.|.|||..
  Fly   533 SSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLGIT 597

Human   323 FGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLV 387
            ||.:|:||||||::||..||.:..|::|.|||.:.|...||.||.:|.|...|:.||..:|.|::
  Fly   598 FGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGMI 662

Human   388 FILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDF-QVLKRHRKLFTFGVTF 451
            |::||:|::.:..:..|||:||.|||.|||:|....:|.|:|.:.|.| :.:|||.......|.|
  Fly   663 FVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVLF 727

Human   452 STFLLALF---CITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRP 513
            ...:..||   .|.:||||...|:|.:||..:|:|....:.|.::||||..|.|.:::||.|..|
  Fly   728 VCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAP 792

Human   514 GLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDD--YIFPPWANWVGWGIALSSMVLVPIYVIYK 576
            ..|.|.||..:.|..|..:.|:|:||:...||.:  |.:|.||..:||..|..|::.:|.|.:..
  Fly   793 SFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVIN 857

Human   577 FLSTQG-SLWERLAYGITPE-------NEHH 599
            ||.:.| :.|||:...:.|.       .|||
  Fly   858 FLRSSGDTFWERIRNTLRPNIYECKICGEHH 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A2	NP_001165975.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		7/20 (35%)
		SLC6sbd_NET	56..612	CDD:212081	225/562 (40%)
ine	NP_477012.1	SLC5-6-like_sbd	337..876	CDD:444915	220/547 (40%)