Protein Alignment SKOR2 and Snoo

DIOPT Version :10

• Sequence 1: NP_001264992.1
• Gene: SKOR2 / 652991
• HGNCID: 32695
• Length: 1015
• Species: Homo sapiens
• Sequence 2: NP_609164.3
• Gene: Snoo / 5740414
• FlyBaseID: FBgn0085450
• Length: 1223
• Species: Drosophila melanogaster
• Alignment Length: 1310
• Identity: 268/1310 - (20%)
• Similarity: 398/1310 - (30%)
• Gaps: 490/1310 - (37%)

Human     7 PGPNDI------LLASPSSAFQPDT----LSQPRPGHANLKPNQVGQVILYGIPIVSLVIDGQER 61
            |.|.|:      ...:|...:.|.|    ||||....|:....::.:..|.|..|....:.|:.|
  Fly    72 PEPQDLHHHECSTRGTPPQIYSPATPPRELSQPILSVADAGCGELYETKLEGKTIGCFSVGGEMR 136

Human    62 LCLAQISNTLLKNFSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERL 126
            |||.|..|.:|.:||..:|:.....|||.|.|||..||...:.|..:|...:..|:||:.:||||
  Fly   137 LCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERL 201

Human   127 CKSFL-GENRPPKLP------DNFAFDVSHECAWGCRGSFIPARYNSSRAKCIKCSYCNMYFSPN 184
            |.:.| ..:|...:|      ...:|.|.|:|...|.|...|..|:..:..||||..|:.:|||.
  Fly   202 CAALLHRSDRNSYVPIESLAKGALSFHVYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQ 266

Human   185 KFIFHSHRTPDAKYTQPDAANFNSWRRHLKLT-DKSPQDELVFAWEDVKAMFNGGSRKRALPQPG 248
            ||:.|.||..: .:|.....:..:|..:|.:. |...:::.....:.:|.:        .|.:
  Fly   267 KFVGHVHRKFE-NHTCHWGFDSRNWHDYLHVALDVENREKYQIILDQLKEV--------ELKE-- 320

Human   249 AHPACHPLSSVK-AAAVAAAAAVAGGGGLLG----PH-LLGAPPPPPPPPPPLAELAGAPHAHHK 307
            .|.|...|...| .|.:.....:.|.|.:||    || |:||..||||||             .|
  Fly   321 MHKAQRELEHKKRKAEMLMDDGMLGSGPVLGLAGHPHGLVGALAPPPPPP-------------MK 372

Human   308 RPRFDDDDDSLQ----EAAVVAAASLSAAAASLSVAAASGGAGTGGGGAGGGCVAGVGVGAGAGA 368
            :|:.|......|    :.|.|||   ||......|..|.             ||
  Fly   373 QPQMDIPSGKKQLQQLKGATVAA---SALEYQYQVMYAH-------------CV----------- 410

Human   369 GAGAGAKG--------PRSYP---------VIPVPSKGSFGGVLQKFPGCGGLFPHPYTFPA--- 413
                 .|.        |.|:|         |...|                  :||...:|.
  Fly   411 -----QKEREREREHLPHSHPLPRQHRAVLVATTP------------------YPHLPQYPTPPT 452

Human   414 --AAAAFSLCHKKEDAGAAAEALGGAGAGGAGAAPKAGLSGLFWPAGRKDAFYPPFCMFWPP--R 474
              :::||. ....:...|...|.|            |.||.|            |:....||  :
  Fly   453 LNSSSAFR-PWGPDTTKAFLHAYG------------ATLSSL------------PYACQEPPELQ 492

Human   475 TPGGLPVPT---YLQPPPQPPSALGCALG-------------ESPALLRQAF------------- 510
            .|..:...|   |.:...||..||.....             |...:.||..
  Fly   493 NPERVVRSTDKRYAERTYQPNVALAPRKSILSKERDKDRERMEREVMERQRLREKETDHQVVHIK 557

Human   511 ---------------------LDLAEPGGAAGSAEAAPPPGQPPQVVANGP---GSGPPPPAGGA 551
                                 ||:.||...:.|...:|.|...|...|..|   |..||.|....
  Fly   558 QERSQTPTPPTASPPDGVVLPLDVVEPPHPSSSGSNSPLPAHLPAAPATAPPNAGGAPPTPTNLR 622

Human   552 GSRDALFESPPGGSGGDCSAGSTPPADSVAAAGAGAAAAGSGPAGSRVPAP--HHPHLLEGRKAG 614
            ..|..  |....|...:.::.::|.....:........||:.|....:.|.  .|..||.
  Fly   623 NMRSP--EEFSAGGSNEITSSTSPHHQQSSHHQVVQPTAGAPPPSQHIIATVNQHAKLLP----- 680

Human   615 GGSYHHSSAFRPVGGKDDAESLAKLHGASAGAPH-----------------SAQTHPHHHHHPHH 662
                  ||:..|.|  :.:.|||    |:...|.                 |..|..||.|||.|
  Fly   681 ------SSSSLPNG--NGSSSLA----ATNNEPSRIRINKNLMSQQPVVAVSGMTPHHHQHHPTH 733

Human   663 HHHHHH---------PPQPPSPLLLLPPQPDEPGSERHHPAPPPPPPPPPPPPLAQHPHHRGLLS 718
            .||..|         |.|..|..|.|........|..||...|             ..||..:.|
  Fly   734 MHHFSHGYYKSQASSPTQSSSAGLNLSTHSSNVVSSPHHATQP-------------KTHHSSVGS 785

Human   719 -------------------------------PGGTSCCYPSEDSSE------------------- 733
                                           |..::...|.|.:.|
  Fly   786 GNHGLQNGKPHLGSEFELSTDTDDTDSLNGEPDSSAMLPPWEQAVESLRETRPKDRERVLLILQR 850

Human   734 --DEDDEE--------------------------------EEQEVDVEGHKPP------------ 752
              .|:|:.                                |||...|:..|.|
  Fly   851 LLQENDQYRYNNIQLSELLHKQDAHIADLTEQLQRYRRQFEEQVCKVDLRKMPFKHQTRLENVVE 915

Human   753 ----EGEEEEEGRDPDDDEEED-------EETEVLLGDPLVG--------------GG------- 785
                |.||:||   .::||.||       :|...|:..|..|              ||
  Fly   916 AGRGEAEEDEE---LEEDEMEDRANNNNQQELSPLIKAPANGLRRSVTPPNCCASEGGDCEKPDE 977

Human   786 ------RFLQGRGPSEKGSSRDRAPAVAGAFPLGLNSSRL--LQEDGKLGDPGSDLPPPPPPPLA 842
                  :...|....:|....:.:|:      .|..|..|  |:::....||.::       |.:
  Fly   978 PESKRIKLQVGEKAEDKQVENEESPS------NGTESHDLEKLEKNDDKTDPTNN-------PKS 1029

Human   843 PQKASGGGSSSPGSPVHHPSLEEQPSYKDSQKTKENNQVIVSTKDDNSFSDKNKEHSFFITDSDA 907
            ||         |........:||..  :|..:..|:.:|.|.....::.:......:....||.|
  Fly  1030 PQ---------PSQISSDDEMEEDD--EDEDEEDEDEEVQVEAPHSSALATPPTATTPLSPDSAA 1083

Human   908 SGGDFW-----RERSGEHTQETNSPHSLKKDVENMGKEELQKVLFE------------------- 948
            :.|..:     .:.|.....:.::.|:|:|...|:|.:|..:.|.|
  Fly  1084 TAGQLFDSSNSSDESSMKKAQMSACHALEKMSSNVGSDENNQRLAEESQEDEAEEDPEEEDSDDD 1148

Human   949 QIDLRRRLEQEFQ------VLKG---------------------------------NTSFPVFNN 974
            ::.|::|.:|:.|      ||.|                                 .|:.....|
  Fly  1149 EMPLQQRQQQQRQRVAPQNVLSGPSVAGHHPAPAHPPMATKASKKQTPPAPPTAAATTTASATTN 1213

Human   975 FQDQMKRELA 984
            .:.|:|:|:|
  Fly  1214 CELQIKKEIA 1223

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SKOR2	NP_001264992.1	DHD_Skor	41..131	CDD:410783	33/89 (37%)
		c-SKI_SMAD_bind	144..236	CDD:471667	26/92 (28%)
Snoo	NP_609164.3	DHD_Ski_Sno	116..206	CDD:410782	33/89 (37%)
		c-SKI_SMAD_bind	226..317	CDD:198114	26/99 (26%)
		AF-4	637..>789	CDD:461550	40/181 (22%)