Protein Alignment SLC6A1 and slc6a1b

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_001007363.1
• Gene: slc6a1b / 492490
• ZFINID: ZDB-GENE-041114-57
• Length: 600
• Species: Danio rerio
• Alignment Length: 601
• Identity: 510/601 - (84%)
• Similarity: 554/601 - (92%)
• Gaps: 3/601 - (0%)

Human     1 MATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLG 65
            |||||:|.:||.:.|||:|||.||||||||||||||| .:||||:||:|:||||:||||||||||
Zfish     1 MATNGTKASDGHVLTEVNEAPTANDKPKTLVVKVQKK-KELPDRETWQGKFDFLLSCVGYAIGLG 64

Human    66 NVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAA 130
            |||||||||||||||||||||||||||||||||.||.:|||||||||||||||||||||||||||
Zfish    65 NVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFFLETALGQYTSIGGLGVWKLAPMFKGVGLAAA 129

Human   131 VLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWER 195
            ||||||||||||||:||||||||||||.||||.||||||||:|||||||.|..||||||||||||
Zfish   130 VLSFWLNIYYIVIIAWAIYYLYNSFTTDLPWKSCDNPWNTDKCFSNYSMANIGNMTSAVVEFWER 194

Human   196 NMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVT 260
            ||||:||||:|||:||.||||||||||:|||||||||||||||||||||||||.||.|||.||||
Zfish   195 NMHQLTDGLEKPGEIRLPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYFMLFILFIRGVT 259

Human   261 LPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCC 325
            |||||||||||:||.|.||.:|||||||||||||||||||||||||||||.|:||||:|||||||
Zfish   260 LPGAKEGILFYVTPEFSKLKESEVWLDAATQIFFSYGLGLGSLIALGSYNPFNNNVYKDSIIVCC 324

Human   326 INSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLL 390
            |||.||||||||||||||||||:|||.||||||||||||||||||||||||||||||:|||||||
Zfish   325 INSFTSMFAGFVIFSIVGFMAHITKRPIADVAASGPGLAFLAYPEAVTQLPISPLWAVLFFSMLL 389

Human   391 MLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSA 455
            |||||||||||||||||||||:||.||.|||:|||.||::|||||||||||||:|||||||||||
Zfish   390 MLGIDSQFCTVEGFITALVDEFPRALRGRREIFIAVVCLVSYLIGLSNITQGGLYVFKLFDYYSA 454

Human   456 SGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMT 520
            |||.|||||||||||||||||||:||.|::||:|.:|||||||||..|||:||||||:||||||.
Zfish   455 SGMCLLFLVFFECVSISWFYGVNKFYGNLEEMIGYKPCIWWKLCWVVFTPLIVAGVFLFSAVQMV 519

Human   521 PLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDIVR-PENGP 584
            |||:.|||||||||||||.|||||||||||||.|||||||||.|:|:::|:||:...|| .||||
Zfish   520 PLTLNNYVFPKWGQGVGWCMALSSMVLIPGYMGYMFLTLKGSYKERLRIMIQPTAAAVRTQENGP 584

Human   585 E-QPQAGSSTSKEAYI 599
            | ||:..:..:.||||
Zfish   585 EQQPENPTPANDEAYI 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	507/598 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		11/23 (48%)
		PDZ-binding	597..599		1/1 (100%)
slc6a1b	NP_001007363.1	SLC5-6-like_sbd	2..600	CDD:444915	507/598 (85%)