Protein Alignment SLC6A1 and Gat

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Alignment Length: 621
• Identity: 342/621 - (55%)
• Similarity: 446/621 - (71%)
• Gaps: 46/621 - (7%)

Human     1 MATNGSKVADG----------QISTEV-------SEAPVAND-KPKTLVVKVQKKAADLPDRDTW 47
            |.||.:...||          ::|.|:       |.:|...| ..|..:||:::    ||||.:|
  Fly     1 MYTNSASDGDGGGDVCKHESIEMSKELGHTTSLQSSSPTTTDTSNKQQLVKIEQ----LPDRGSW 61

Human    48 KGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGG 112
            ..:.||::|.||.||||||||||||||.|||||||::||.:||..||:|:|.:|.:|||..:|||
  Fly    62 SSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQMLTIGG 126

Human   113 LGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNY 177
            |||:|:||:|||:|.||||:|.|:|:|||||::||::|.:.|....:||:.|:|.|||..|.|.|
  Fly   127 LGVFKIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQY 191

Human   178 ----------------------SMVNTTN--MTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITL 218
                                  |.:|.|:  :|..|.|||||...|::.|:::.|.|||.||.||
  Fly   192 ERKNLHCWDKIINGTTQKVCSVSALNITSLELTDPVKEFWERRALQISHGIEEIGNIRWELAGTL 256

Human   219 AIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSE 283
            .:.|||.||||||||.||||||||:|.:||::|.||..||:|||||.|||.|||.|||.||::||
  Fly   257 LLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSE 321

Human   284 VWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHV 348
            ||:||.||||||||||||:|:||||||.|.||||:|::|||.:||.|||||||||||::|||||.
  Fly   322 VWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHE 386

Human   349 TKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYP 413
            .:|.:|||||||||||||.||.||.|||.||:|:.|||.|||::|:||||||:||||||::||:|
  Fly   387 QQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITAIIDEWP 451

Human   414 RLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVN 478
            :|||.|:|:|||.||.:|||:||:.|||||:|:|::.|.|:.||..||:|:|||||||||.|||:
  Fly   452 QLLRKRKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVD 516

Human   479 RFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALS 543
            ||||.|::|:|..|.:|||.||...||.|..|||.|:.||.||:...:|.:|.|....||..|||
  Fly   517 RFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLDYSYPWWAHAFGWFTALS 581

Human   544 SMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDIVR 579
            ||:.||.||.:::....|.|.::|:.:|:..||:.|
  Fly   582 SMLYIPLYMFWLWKRTPGELSEKIRALVRIDEDVTR 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	341/620 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		1/3 (33%)
		PDZ-binding	597..599
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	323/552 (59%)