Protein Alignment SLC6A1 and blot

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_524125.2
• Gene: blot / 39939
• FlyBaseID: FBgn0027660
• Length: 976
• Species: Drosophila melanogaster
• Alignment Length: 600
• Identity: 134/600 - (22%)
• Similarity: 242/600 - (40%)
• Gaps: 115/600 - (19%)

Human    33 KVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPL 97
            |:.....|..::.|....|..|:.|:...:...||.|||....:. |.|:|:||.:.|...|:|:
  Fly   201 KLLPAVEDESNKQTKCSVFRGLVLCLCLNLSYANVVRFPRELDRY-GSAYLVPYVVLLFLVGLPM 264

Human    98 FLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIIS-WAIYYLYNSFTTTLPW 161
            .|||.|:||:...|....|:.:|:|||..:.:...| ||:..::.:.: .|:.|:....:..||:
  Fly   265 VLLEISVGQFLGQGAAHTWRASPIFKGACMISRFAS-WLSAIWVSLQAVLALAYIGMFASNDLPF 328

Human   162 KQCDNPWNTDRCFSNYSMVNTTN----MTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAW 222
            ::|..|  .....|.|.:..|:.    ..:.:..||...::   .||         ||..|...|
  Fly   329 RECAGP--VKLRLSGYLLTGTSGQECLQLTFLTPFWRNPLY---FGL---------LAAGLIGLW 379

Human   223 ILVYFCIWKGVGWTGKVVYFSA-TYPYIMLIILFFRGVTLPG--AKEGILFYITPNF-----RKL 279
            |:|..|.     ...|::..|. .:..:.|::|    .||.|  .:.....:..|..     ..|
  Fly   380 IVVMLCT-----HNAKILRRSIFVFGLVGLVLL----CTLTGWEVRNSFSRHYFPELWGFDSNLL 435

Human   280 SDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGF 344
            ::|.:|.:|..|:.||...|.|:|..:.....:..:..|.|::..|.|...:..|  |...:|.|
  Fly   436 AESNIWFNALMQVLFSVNCGFGALPMITGKFLYKGDAVRTSVVYLCFNLLINAIA--VTLFMVQF 498

Human   345 MAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAI----------------------LFFS 387
                      |::::|    |....|      :.||.||                      |.::
  Fly   499 ----------DLSSNG----FQNMEE------LKPLTAIYDRVLNGSREGDSHLLQHLVPSLIYA 543

Human   388 MLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDY 452
            ::::..:.|        ||..|....||: .||..::  :|:|..::.:.:.......:.::.|.
  Fly   544 LIILSAMVS--------ITVAVYTSTRLV-PRRPNYV--ICLIGLVVAVISFAAPKFLIARVLDS 597

Human   453 YSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPC--IW---WKLCWSFFTPIIVAGVF 512
            .....|.:..|| ||.::|:|.||....|.:::..:| ||.  :|   |.:|     |.|:.|:.
  Fly   598 RLVGTMVVTALV-FELIAITWIYGAKNIYTDLEFSIG-RPIFRVWMWLWVIC-----PAILTGIL 655

Human   513 IFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDI 577
            ::.........:.....|:|..   .|..|:.:|:|.  ...:|..::.:....|....:|::
  Fly   656 VWWCADDDQYDLLAEYLPRWAP---ILFVLAVIVIIA--CVQIFRQVEYNFFGMICEASKPAK-- 713

Human   578 VRPENGPEQPQAGSS 592
               |.||..|.|..|
  Fly   714 ---EWGPADPLARHS 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	133/599 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		5/15 (33%)
		PDZ-binding	597..599
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	116/504 (23%)