Protein Alignment SLC6A1 and CG4476

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_648293.1
• Gene: CG4476 / 39056
• FlyBaseID: FBgn0035969
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 599
• Identity: 205/599 - (34%)
• Similarity: 340/599 - (56%)
• Gaps: 32/599 - (5%)

Human     8 VADGQISTEVSEAPVAND---KPKTLVVKVQKK--AADLPDRDTWKGRFDFLMSCVGYAIGLGNV 67
            |:.|....|.|....:.:   ||..|.:.::..  :.|...||.|....:|||||:..::|||||
  Fly    10 VSGGLPKLETSRCAGSGEALLKPSLLPMALESSELSPDRKARDNWGSSLEFLMSCIALSVGLGNV 74

Human    68 WRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVL 132
            ||||:...:||||||||||.:.|...|.|::.:|..|||::|.|.:.|:..||:.:|||.|..:.
  Fly    75 WRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMRGVGYAQLLA 139

Human   133 SFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFS-----NYSMVNTTNMTSAVVEF 192
            ...|..||..:::..:.|.::||.:.|||..|...|. |.|.|     ......:.|.:|:...:
  Fly   140 LGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG-DGCVSASGGQPLQGQLSRNFSSSTQLY 203

Human   193 WERNMHQMTDGLDKPGQIRWP---LAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIIL 254
            .:|.:...||.|::  .|.:|   ||:.|.|:|:.|...|.:||..:||..|..|.:||:::.||
  Fly   204 LQRIVLNETDSLEE--GIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFIL 266

Human   255 FFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRD 319
            ..|.:|||||.:|:::::||.:.||.:.:||.:|.||:|||..:..|.:|...|||.|.:|||||
  Fly   267 LVRALTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRD 331

Human   320 SIIVCCINSCTSMFAGFVIFSIVGFMAHVT-KRSIADVAASGPGLAFLAYPEAVTQLPISP-LWA 382
            :.||..:::.||:.:|.:||.|:|.:||.: .:.||.|..:||||||::||:|:.:..:.| :::
  Fly   332 ANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFS 396

Human   383 ILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVF 447
            :|||:||.|||:.|....|...:|.|.|::..:   :..:.:.::.:|.:|:||..||.||.::.
  Fly   397 LLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNV---KLWIIVVSLSVIGFLVGLIYITPGGQHII 458

Human   448 KLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVF 512
            .|.|::..:.:||:..: ||.:::.|.||..|...:.:.|:..:...::::|||..||:::..:.
  Fly   459 TLMDFHGVTFVSLVSAI-FELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVIL 522

Human   513 IFSAVQMTPLTMGNYVFPKWGQGVGWLMA---LSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPS 574
            ::|.:.|.||:.....||...:.|||.::   :..:....||.  .|...|||||.||...::|.
  Fly   523 VYSLLTMRPLSYNGQEFPLVYRVVGWCVSGCIIGQLFYWAGYA--NFKQPKGSLKSRINNSIKPH 585

Human   575 EDIVRPENGPEQPQ 588
            .|.     ||..|:
  Fly   586 SDW-----GPSDPK 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	205/599 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		3/12 (25%)
		PDZ-binding	597..599
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	172/480 (36%)