Protein Alignment SLC6A1 and SerT

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_001369117.1
• Gene: SerT / 37895
• FlyBaseID: FBgn0010414
• Length: 768
• Species: Drosophila melanogaster
• Alignment Length: 599
• Identity: 267/599 - (44%)
• Similarity: 382/599 - (63%)
• Gaps: 23/599 - (3%)

Human     3 TNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNV 67
            |..:||.|       ..||...:..:.|||.|.::.     |:||..:.:||::.:|:|:.||||
  Fly    45 TTPAKVTD-------PLAPKLANNERILVVSVTERT-----RETWGQKAEFLLAVIGFAVDLGNV 97

Human    68 WRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWK-LAPMFKGVGLAAAV 131
            |||||:|.:|||||||:||.|.|||.|:|||.:|.:|||:...|.|.:|| :.|..||||.|..:
  Fly    98 WRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICL 162

Human   132 LSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERN 196
            :..::.:||..||.||:|||:.|||:.|||..|||||||:.|....|...|...||...||:||.
  Fly   163 IDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENCMQVTSENFTELATSPAKEFFERK 227

Human   197 MHQ--MTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGV 259
            :.:  ..:|||..|.::..||:.:...::||||.:||||...||||:.:|..||::||||..|||
  Fly   228 VLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILLVRGV 292

Human   260 TLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVC 324
            :||||.|||.:|:||.:.||.:|:||:|||:|||||.|.|.|:|:||.|||.|:||.|||::|..
  Fly   293 SLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDALITS 357

Human   325 CINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSML 389
            .||..||..|||||||::|:||:|.|.||..|...||||.|:.||||:..:..|..|:|:||.||
  Fly   358 SINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFIVYPEAIATMSGSVFWSIIFFLML 422

Human   390 LMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYS 454
            :.||:||.|..:|..||||.|||||::..|||||:..:....:|..|..:|.||:.:....:.|
  Fly   423 ITLGLDSTFGGLEAMITALCDEYPRVIGRRRELFVLLLLAFIFLCALPTMTYGGVVLVNFLNVY- 486

Human   455 ASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQM 519
            ..|:::||:||.|...:.|||||:||..::::|:||:|.::|::||::.:|:.:..:||||.:..
  Fly   487 GPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSIMGY 551

Human   520 TPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAY-MFLTLKGSLKQRIQVMVQPSEDIVRPENG 583
            ..:....|.:|.|...|||.:..||::.||.|:.| .|...||..:||:|...||.::.     |
  Fly   552 KEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKGGCRQRLQESFQPEDNC-----G 611

Human   584 PEQP-QAGSSTSKE 596
            ...| |.|:|...:
  Fly   612 SVVPGQQGTSVXHD 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	267/599 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		5/21 (24%)
		PDZ-binding	597..599		267/599 (45%)
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	251/533 (47%)