Protein Alignment SLC6A1 and GlyT

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_611836.2
• Gene: GlyT / 37772
• FlyBaseID: FBgn0034911
• Length: 1188
• Species: Drosophila melanogaster
• Alignment Length: 576
• Identity: 243/576 - (42%)
• Similarity: 353/576 - (61%)
• Gaps: 51/576 - (8%)

Human    43 DRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQY 107
            :|.||.||||||:|.:||::||||||||||||..|||||||||:.:.|:.||:||..:|.|.|||
  Fly    56 ERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQY 120

Human   108 TSIGGLGVW-KLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTD 171
            .::|.:.|: :..|:|:|:|....::|..:.:||.:||:|.|:|::.||...|||:.|:..|:|.
  Fly   121 AALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNCEPAWSTK 185

Human   172 RCFS------------NYSMVNTTNMTSA-----------------VVEFWERNMHQMTDGLDKP 207
            .|||            .|.:....|.|||                 ..|::...:..::.|:::.
  Fly   186 YCFSYAQADQCEATNGTYYLRTCHNATSAAENNITTLALGALKRPPAEEYFNNFVLGLSKGIEET 250

Human   208 GQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYI 272
            |.|:..||..|.:||.:|:.|:.|||..:||||||:|.:||::|:|||.||||||||..|||||:
  Fly   251 GSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVTLPGASTGILFYL 315

Human   273 TPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFV 337
            ||::::|::::||.|||.||||:.....|.||.|.|||.|.||.|:||:||...|..||.|||.|
  Fly   316 TPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVAFCNIATSFFAGLV 380

Human   338 IFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVE 402
            ||||:||:||.....:..|...|.||||:.|||.||:||:||:||:|||.|||.||:||||..:|
  Fly   381 IFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVMLLTLGLDSQFALME 445

Human   403 GFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFE 467
            ...||::|.:|. ||..:...:.:|.|..|:.||...|..|:|..:|.|.|:|: .|:|.:...|
  Fly   446 TVTTAILDRFPN-LRQYKIWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDKYAAN-WSVLLIAISE 508

Human   468 CVSISWFYGVNRFYDNIQEMVGSRPCIW---WKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVF 529
            |:.|:|.||..||.::||.|:|.|...|   |.:.|.:.||..:..:..|:.|:..|...|:||:
  Fly   509 CILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWGIMWRYITPATLLFILFFNWVEYKPAKYGHYVY 573

Human   530 PKWGQGVGWLMALSSMVLIPGYMAYMFLT---------LKGSLKQRIQVMVQPSED 576
            |.|...|||::.|..:::|       ||.         :..|.:.||:.::||:.:
  Fly   574 PMWADAVGWIVGLLPVLVI-------FLVAFQEIWRAPMSLSFRDRIKHLLQPTAE 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	243/576 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		243/576 (42%)
		PDZ-binding	597..599
GlyT	NP_611836.2	SNF	57..597	CDD:395155	238/548 (43%)
		Herpes_BLLF1	<884..1135	CDD:282904