Protein Alignment SLC6A1 and List

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_611364.2
• Gene: List / 37157
• FlyBaseID: FBgn0034381
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 560
• Identity: 195/560 - (34%)
• Similarity: 316/560 - (56%)
• Gaps: 29/560 - (5%)

Human    31 VVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGV 95
            :.|..:|.|:.| .:.|....:||.||:..::||||:|||||:..:||||.|:|||.:.|:..|.
  Fly     6 ISKKSEKPAEKP-AEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGR 69

Human    96 PLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLP 160
            |::.||.||||:|..|.:..:.:||:.|||.|...:.:.....||..|::..:.:...||.:.||
  Fly    70 PVYYLEISLGQFTGRGVVKAFDMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELP 134

Human   161 WKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQ---MTDGLDKPGQIRWPLAITLAIAW 222
            |.:|...|.|| |....:..::..|:.|.:.|....:|:   :.:||..|   .|.|...|||||
  Fly   135 WSRCWESWGTD-CHDGNAQNSSGKMSPAQLYFEREILHEVPNIDNGLSLP---NWQLVACLAIAW 195

Human   223 ILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLD 287
            :::...:.:|:..:||..||...:||::|:||..|.||||||.:||:::..|.:|:|.:..||..
  Fly   196 LVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYA 260

Human   288 AATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVT-KR 351
            |.||:|||..:..|:||...|||:|:.|||.|.:|:..::||:|:.||.:.|.|:|.:|..| ..
  Fly   261 AVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGNP 325

Human   352 SIADVAASGPGLAFLAYPEAVTQLPISP-LWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRL 415
            .|..|...|.||||::||||:.:....| ::|:|||.||.:|||.|   || |..:.::    |:
  Fly   326 DIGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGS---TV-GMGSCIL----RV 382

Human   416 LRNRREL-------FIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISW 473
            :|::..|       ..:.:.::.:.:.:..:|.||.::..|.|:|..| .:.|.|...|.|:::|
  Fly   383 IRDQFGLRSPPIWKLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVS-FTALILAIGELVAVAW 446

Human   474 FYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGW 538
            .||||||.::|:.|:|.....:|:|||.|.||.::..|.|:..:.|:.|......:|......|.
  Fly   447 IYGVNRFCEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGVGYPTLAHVFGC 511

Human   539 LMALSSMVLIPGYMAYMFLTLK---GSLKQRIQVMVQPSE 575
            .:|...::.:||:..|.....:   ||..|||:...:||:
  Fly   512 FLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKPSD 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	195/560 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	176/482 (37%)