Protein Alignment SLC6A1 and CG43066

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Alignment Length: 631
• Identity: 219/631 - (34%)
• Similarity: 335/631 - (53%)
• Gaps: 104/631 - (16%)

Human     4 NGSKVA--------DGQIS-TEVSEAPVANDKPKTLVVKVQKKAADL----PDRDTWKGRFDFLM 55
            ||.::|        ||... |.|..||..|        .||  :.|:    |:|..|.|:..|.:
  Fly    12 NGHEMAPLNTRARGDGTHGVTIVLTAPQRN--------SVQ--SVDIPGNEPERAAWSGKMQFFL 66

Human    56 SCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWK-LA 119
            |.:||::||||:|||||||.:|||||||||:.:.||..|:||||:|..:||...:|.||||. :.
  Fly    67 SIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQRMRLGALGVWNTIH 131

Human   120 PMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWN-----TDRCFSNYSM 179
            |...|:|:::.:::.::.:||.|||:|..:||:|||...|||..|  |.|     .:.|..
  Fly   132 PWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSC--PLNGTGFELEECAK---- 190

Human   180 VNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSA 244
                  :|....||.|........:|:||.::|.:.:.|.::|.:|:|.:.||:..:||||||::
  Fly   191 ------SSETTYFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKVVYFTS 249

Human   245 TYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSY 309
            .:|||:|.|.|.||:||.||..|::...||...||.:..||||||||:|:|:||..|||||.|||
  Fly   250 LFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIAFGSY 314

Human   310 NSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHV-TKRSIA------------------- 354
            |:..||..||.::|...|:.|:::|..|||:|:||.|.| ..|.:|
  Fly   315 NTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNTEILVKNKLLGLNDTQG 379

Human   355 ---------------------------DVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLML 392
                                       |.||.|.||||:.:.:|:.:||.:|.||:|||:|||.|
  Fly   380 YEQAMSLLNGTELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVELPGAPFWAVLFFTMLLSL 444

Human   393 GIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASG 457
            |:.||...:||.:..|.| ...:.|.:::.....||:..:::|....|..|.|..|:||.: |..
  Fly   445 GLGSQIGILEGMLCTLFD-IDIIKRVKKQHVTGVVCLFCFIVGFIFCTGAGEYWLKMFDSF-AGT 507

Human   458 MSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPL 522
            :.|:.:...|.:::.:.||..||.::|.:|.|.||..:|:..|.:..|:|:..:.:.|.|.|
  Fly   508 IGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQWTWRYIGPVIMVCILVSSVVFM--- 569

Human   523 TMGNYVFPKWGQGVG---------WLMALSSMVLIPGY--MAYMFL 557
            .:.|..:..|...:|         |:|.::..:::.|.  |..:||
  Fly   570 VIRNPTYGAWNADLGMIEQKSYPNWVMGIALSMILAGVLPMPIVFL 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	219/631 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	205/578 (35%)