Protein Alignment SLC6A1 and DAT

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Alignment Length: 608
• Identity: 261/608 - (42%)
• Similarity: 380/608 - (62%)
• Gaps: 55/608 - (9%)

Human    11 GQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCG 75
            |.||...:..|..||         ....:|  :|:||.|:.|||:|.:|:|:.|.|||||||||.
  Fly     5 GHISKSKTPTPHDND---------NNSISD--ERETWSGKVDFLLSVIGFAVDLANVWRFPYLCY 58

Human    76 KNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVW-KLAPMFKGVGLAAAVLSFWLNIY 139
            ||||||||:||.:.|:..|:|||.:|.:|||:...|.:..| :|.|:|||:|.|..:::|:::.|
  Fly    59 KNGGGAFLVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFY 123

Human   140 YIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRC-------------FSNYS----------MVN 181
            |.|||:|::.:.:.|||.:|||..|:|.|||..|             ..|||          :.|
  Fly   124 YNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYN 188

Human   182 TTNMT----------------SAVVEFWERNMHQM--TDGLDKPGQIRWPLAITLAIAWILVYFC 228
            .|.|.                ||..|::.|.:.::  ::|:...|.|:|.:|:.|.|.:::.||.
  Fly   189 ETYMNGSSLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFS 253

Human   229 IWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIF 293
            :|||:..:||||:|:|.:||.:|:||..||:||||:..||.:|:||||..:..:|||:|||||:|
  Fly   254 LWKGISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVF 318

Human   294 FSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAA 358
            ||.|.|.|.|:|..|||.:|||||:|:::...|||.||..|||||||::|:|||.....|.|||.
  Fly   319 FSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVAT 383

Human   359 SGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELF 423
            .||||.|:.||.|:..:|.|..||::||.|||.||:||.|...|..||||.||:|::.|| ||||
  Fly   384 EGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRN-RELF 447

Human   424 IAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMV 488
            :|.:..:.:::||::.||||.|.|.|.|.| |:|.|:|..||||.:::||.||.|||.::|::|:
  Fly   448 VAGLFSLYFVVGLASCTQGGFYFFHLLDRY-AAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMI 511

Human   489 GSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMA 553
            |..|..:|::||.|..||.:..:.::..:...|||..:||:|.|...:||.:|.||:|:||....
  Fly   512 GFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAI 576

Human   554 YMFLTLKGSLKQRIQVMVQPSED 576
            :..|:..|||:||..::..|..|
  Fly   577 FKLLSTPGSLRQRFTILTTPWRD 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	261/608 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		261/608 (43%)
		PDZ-binding	597..599
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	252/571 (44%)