Protein Alignment SLC6A1 and bdg

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_611064.2
• Gene: bdg / 36747
• FlyBaseID: FBgn0034049
• Length: 1331
• Species: Drosophila melanogaster
• Alignment Length: 654
• Identity: 156/654 - (23%)
• Similarity: 268/654 - (40%)
• Gaps: 168/654 - (25%)

Human    55 MSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLA 119
            ::.:|..:|:.|:.||..|. .|.||.||:.:.|..:..|:||..|:..||.....|.:.:||::
  Fly   505 LALIGCTLGVFNMCRFAVLT-INFGGNFLLQFLLLSVIFGIPLLWLQMCLGAKIRAGPVSMWKIS 568

Human   120 PMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTT----LPWKQCDNPWNTDRCFSNYSMV 180
            |:..|||:|..:...:|.:|..|.::|.:.||.:.|.|.    ..|::...|:..|.  ||
  Fly   569 PICAGVGIALVMQQCFLALYSTVSLAWILVYLRDVFPTAARSGYRWQEMAFPYRYDA--SN---- 627

Human   181 NTTNMTSAVVEFWE----RNMHQMTDGLDKPGQIRW-----PLAITLAIAWILVYFCIWKGVGWT 236
            .|.|:|..|.|::.    :.:| :.:..|..| ||:     .||..||:.|..|:..:.||:...
  Fly   628 ATGNLTQTVAEYFNVVVLQRLH-LANHPDASG-IRFHVNDRQLAFYLALIWAAVFLILCKGLKSL 690

Human   237 GKVVYFSATYPYIMLIILF--FRGVTLPGAKEGILFYITPNFRK-LSDSEVWLDAATQIFFSYGL 298
            ||:.|...|.|.:.|.::.  |..|..|...:.|  :...:|.. |.:|..|..|..:.|.::||
  Fly   691 GKLAYIIYTLPLVALAVVTAKFVYVVDPSRIQNI--FAASDFDDFLVNSNSWTAATQETFLTWGL 753

Human   299 GLGSLIALGSYNSFHNN-----VYRDSII----------------VCCIN--------------- 327
            ...|:||:.|.:  |.|     :.||:|:                :||..
  Fly   754 LGASVIAITSRS--HTNANKAALRRDAILLVLFTLIGLGLMALLALCCAQILWQHGYVYVPGSFE 816

Human   328 --SC-TSMFA------GFVIFSIVGFMAHVT---------KRSIADVAASGPGLAFLA--YPEAV 372
              .| ||:::      .:::......:.|.:         .|::..|.:....|.|::  :| ||
  Fly   817 NPDCYTSIYSLQSNTNPYLLSYPRSLIPHYSSFIGETYRRNRTMIHVESGFQALRFISEIFP-AV 880

Human   373 TQL---PISPLWAILFFSMLLMLGIDSQFCTV-EGFITALVDEYPRLLRNRRELFIAAVCIISYL 433
            ..|   .||.:||.:.|:.....|: :|.|.: :...:||.:....:|.:         |:...|
  Fly   881 LSLASDSISWVWAAVAFATFAGFGL-AQLCVMWKPISSALGNSTSSVLLS---------CVTGLL 935

Human   434 IGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWF---------YGV----NRFYD--- 482
            :.:...|:.||              |:|:.|.| .:..|||         :||    .|.|:
  Fly   936 LSIPFATEMGI--------------SILYYVDF-LLGGSWFIPIIWTAQIFGVFLIRGRPYNGDD 985

Human   483 --NIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTP-------LTMGNYVFPKWGQGVGW 538
              |...:.||... :..|.|:...||   |:...|.|....       ...|...|..|.:.:|.
  Fly   986 LVNDLRLCGSMSA-FLALSWNVLLPI---GLITLSVVDYKASLSNQFYYWRGKSYFTYWSRKMGS 1046

Human   539 LMALSSMVLIP--------GYMAYMFLTLKG--SLKQRIQVMVQPSEDIVRPENG--PEQPQAGS 591
            |:.:..:::||        .|:|:      |  .:.:|||::.:|      ||.|  |.:|.|..
  Fly  1047 LIQIGVLLVIPVTAIIQIYRYLAH------GPPDILERIQLLYRP------PEEGEEPRRPSARQ 1099

Human   592 STSK 595
            :.|:
  Fly  1100 TASQ 1103

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	156/654 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		7/21 (33%)
		PDZ-binding	597..599
bdg	NP_611064.2	SLC5-6-like_sbd	501..976	CDD:271356	123/509 (24%)