Protein Alignment SLC6A1 and CG8850

DIOPT Version :9

• Sequence 1: NP_001335179.1
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 608
• Identity: 197/608 - (32%)
• Similarity: 317/608 - (52%)
• Gaps: 48/608 - (7%)

Human    10 DGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLC 74
            || |||.:..|     :.:.|.:..:.::.....||.|....:||.||:..::|||||||||::.
  Fly    29 DG-ISTVIYSA-----EGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIA 87

Human    75 GKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIY 139
            .:||||||||||.:.|:..|.|::.||..:||::|.|.:..:.:||:.:|:.......:.....|
  Fly    88 LENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTY 152

Human   140 YIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVE---FWERNMHQMT 201
            |..|::..|.||..||:..|||..|...|......:..:..|.:::...|..   |:.:.:.:..
  Fly   153 YACIMALTIRYLVASFSEVLPWTYCLVEWGKSCVATGATAANDSSIVQGVSSAELFFTQTVLREP 217

Human   202 DGLDKP--GQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGA 264
            :.||..  |...|.|.:.|...|:::...:.||:..:||..||.|.:||:::|:|..|.||||||
  Fly   218 ESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGA 282

Human   265 KEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSC 329
            .:||::::.|.:.:|.:..||..|.||:|||..:..|:|:...|:|.|:.||::|.||:..|:|.
  Fly   283 WQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSL 347

Human   330 TSMFAGFVIFSIVGFMAHVTK-RSIADVAASGPGLAFLAYPEAVTQLPISP-LWAILFFSMLLML 392
            ||:.||.:||.|:|.:|..|. :.|:.|...|.||||::||||:.:....| |:|:|||.|||:|
  Fly   348 TSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVL 412

Human   393 GIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASG 457
            ||.|........:..:.|.:..|   ...|...:..||.:|.||..:|.||.:|..|.|:|..:.
  Fly   413 GIGSNIGMASAVVNVVKDRFTHL---PHWLLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTF 474

Human   458 MSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPL 522
            ::|: |...|.:::.|.|||.|...:|:.|:..:...:|::||:...|.::..|.::......||
  Fly   475 IALV-LAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPL 538

Human   523 TMGNYVFPK---------WGQGVGWL--MALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSED 576
            |.....:|.         ||.||..|  .||.::...||          .:...:..:.:||:.:
  Fly   539 TYRGVQYPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPG----------KTFGSKFGLAMQPTAN 593

Human   577 IVRPENGPEQPQAGSSTSKEAYI 599
            .     ||.|.|     ..||||
  Fly   594 W-----GPLQTQ-----KFEAYI 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_001335179.1	SLC6sbd_GAT1	2..599	CDD:212075	195/606 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		6/21 (29%)
		PDZ-binding	597..599		1/1 (100%)
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	166/477 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820