Protein Alignment SLC6A1 and CG1698

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_610517.1
• Gene: CG1698 / 36006
• FlyBaseID: FBgn0033443
• Length: 654
• Species: Drosophila melanogaster
• Alignment Length: 615
• Identity: 206/615 - (33%)
• Similarity: 336/615 - (54%)
• Gaps: 60/615 - (9%)

Human     2 ATNGSK-VADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLG 65
            ::||.| :::|..|   :..|...|.|..:......|     .||:|....:|||||:..::|||
  Fly    39 SSNGKKTLSEGSGS---APPPGHGDSPSGVEAGQPGK-----KRDSWNNDIEFLMSCIALSVGLG 95

Human    66 NVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAA 130
            ||||||:...:||||||:|||.:.||..|.|::.||..|||::|.|.:.|:..:|:.:|:|....
  Fly    96 NVWRFPFTALENGGGAFVIPYLIVLILVGKPVYYLEMLLGQFSSRGSVKVYDFSPIMRGIGYGQV 160

Human   131 VLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSN------------YSMVNTT 183
            :.:..:..||..:::..:.|..:||..||||..|...|.|: |..:            .|.|.||
  Fly   161 LATGIVTTYYATLMALTLRYFVDSFYPTLPWSYCREEWGTE-CLDSGPQEASRATSLAGSGVRTT 224

Human   184 NMTSAVVEFWERNM-----HQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFS 243
            :     .||:..|:     ..:.||:..|.   |.||:.||:|||::...::|||..:||..||.
  Fly   225 S-----AEFYFTNIILREKASIDDGIGYPS---WSLALALAVAWIVIAGIMFKGVKSSGKASYFL 281

Human   244 ATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGS 308
            |.:||:::::|..|.:|||||.:|:|:::.|.:.||.:.:||..|.||:|||..:..|::|...|
  Fly   282 ALFPYVVMLVLLVRALTLPGAFDGVLYFLRPQWHKLLEPQVWYAAVTQVFFSLAICFGNIIMYAS 346

Human   309 YNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRS-IADVAASGPGLAFLAYPEAV 372
            ||.|.:|:|||:.||..:::.||:.:|.:||.|:|.:|:....: ||.|...||||||::||:|:
  Fly   347 YNRFGHNIYRDANIVTTLDTFTSLLSGVIIFGILGNLAYENNTTDIASVVNGGPGLAFISYPDAI 411

Human   373 TQLPISP-LWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGL 436
            .:....| |:::|||.||.:|||.|.........|.:.|::..|   :....:..:.|:.|.:||
  Fly   412 AKFKWLPQLFSVLFFLMLFVLGIGSNVGMASCMSTVIKDQFGHL---KNWTVVVGIAIVGYFLGL 473

Human   437 SNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWS 501
            ..||.||.::..|.||:..:.::|: |..||.|:|:|.|||.|...:::.|:|.:..:::::||:
  Fly   474 LYITPGGQFLLNLVDYFGVTFVALV-LAIFELVTIAWIYGVKRLCRDVEFMIGIKTSLYYRICWA 537

Human   502 FFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQ- 565
            ..||:::..:.|::.|...||...:|.:.......||  .||:.    |....:|..:....||
  Fly   538 VVTPLLMLTILIYTLVLYEPLKYKDYTYQSGVYVFGW--CLSAF----GVGQVLFWAIPAVRKQP 596

Human   566 -------RIQVMVQPSEDIVRPENGPEQPQ 588
                   ||:...:|     .|..||..||
  Fly   597 SHLGLWARIRKAFEP-----LPNWGPSDPQ 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	206/615 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		5/12 (42%)
		PDZ-binding	597..599
CG1698	NP_610517.1	SLC6sbd	75..552	CDD:271359	176/489 (36%)