Protein Alignment SLC6A1 and CG15279

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_609726.1
• Gene: CG15279 / 34863
• FlyBaseID: FBgn0028886
• Length: 639
• Species: Drosophila melanogaster
• Alignment Length: 616
• Identity: 219/616 - (35%)
• Similarity: 331/616 - (53%)
• Gaps: 40/616 - (6%)

Human     8 VADGQISTEVSEAPVANDKPKTLVVKVQKKAADLP-DRDTWKGRFDFLMSCVGYAIGLGNVWRFP 71
            |.|...|| .|...::.:.|........::||.:| :|.||....:|||||:..::|||||||||
  Fly    14 VGDDGRST-ASTVEISTNSPALRDNSDDQEAAKVPEERATWGKGVEFLMSCIAMSVGLGNVWRFP 77

Human    72 YLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWL 136
            :....||||||||||.:.|...|.|::.||..:||::|.|.:.|:.|.|..||||...|...|.|
  Fly    78 FTALDNGGGAFLIPYLIVLFLIGKPIYYLEMVIGQFSSRGSVKVFDLCPAMKGVGAGQAFQVFML 142

Human   137 NIYYIVIISWAIYYLYNSFTTTLPWKQCDNPW------------------NTDRCFSNYSM--VN 181
            :.||..:::....|...||...|||..|...|                  :.|:...||:|  .|
  Fly   143 STYYAALVAIIGRYFIESFRNPLPWSTCRAEWGIHCINSAPDASNWSQLESNDQRPQNYTMKSQN 207

Human   182 TTNMTSAVVEFWERNMHQ---MTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFS 243
            ...:||:...|.:..:|:   :.:|:..|   .|.|.|.|.|||..|:|.|.:||..:||..||.
  Fly   208 DRVITSSEWYFVKEVLHEKPNIEEGIGLP---NWELVIGLFIAWSCVFFIIRRGVKSSGKASYFL 269

Human   244 ATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGS 308
            |.:||:::.:|..|.|||||:.:||.::|.|.:.|:.|.:||..|.||.|:|..:..|::|...|
  Fly   270 ALFPYVIMGVLLVRAVTLPGSIDGIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSS 334

Human   309 YNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAH-VTKRSIADVAASGPGLAFLAYPEAV 372
            :|.|.:||:||:.||..:::.||:.|||.||.|:|.:|| :....|..|...|.||||::||:|:
  Fly   335 FNKFGHNVHRDAAIVTGLDTMTSLLAGFTIFGILGHLAHEIGTDDIGSVVKGGAGLAFISYPDAI 399

Human   373 TQLPISP-LWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGL 436
            .:....| ::::|||.||.:|||.|........:||:.|.:|...:.:..|.||   ::|:.|||
  Fly   400 AKFKNLPQIFSVLFFLMLFVLGIGSNIAMTSCSVTAIRDRFPNFGQWQCSLLIA---VVSFFIGL 461

Human   437 SNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWS 501
            ..||.||.|:..|.|::.|| |..|.|...|..:|.|.||.:|...:|:.|:|.:..::|:||||
  Fly   462 MYITPGGQYMLTLVDFFGAS-MIALVLGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWS 525

Human   502 FFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKG-SLKQ 565
            ..||:|:..:.|:......|||..|.|:|.|...:|||:....::.:|.:|....:...| :|..
  Fly   526 IITPLIMTVILIYFYATYQPLTYNNIVYPNWSYSIGWLITAFGILQLPIWMIVAIVRDPGQTLGA 590

Human   566 RIQVMVQPSEDIVRPENGPEQPQAGSSTSKE 596
            :|:....|.::.     ||..|.......||
  Fly   591 KIRGAFTPKKNW-----GPSDPLLREQYHKE 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	219/616 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		5/20 (25%)
		PDZ-binding	597..599		219/616 (36%)
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:444915	204/554 (37%)