Protein Alignment SLC6A1 and CG13796

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_609140.2
• Gene: CG13796 / 34051
• FlyBaseID: FBgn0031939
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 597
• Identity: 158/597 - (26%)
• Similarity: 254/597 - (42%)
• Gaps: 101/597 - (16%)

Human    19 EAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIG---LGNVWRFPYLCGKNGGG 80
            |.|..:||                .|..|....||..:...:|..   ...:..|..|.|  |..
  Fly    75 ERPYRHDK----------------CRGRWAKSADFYFASCTHAFSSLIFSELSTFGILHG--GWL 121

Human    81 AFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIIS 145
            .|:|.|.:.::|..:|:||::..|||::|.|.:..:::||:|||:|.|..:|:.....||.:...
  Fly   122 LFIIAYLMGMLFYSLPIFLIQAFLGQFSSSGTISAFRVAPIFKGIGYAILLLNLGTLTYYSIAAV 186

Human   146 WAIYYLYNSFTTTLPWKQCDNPWNTDRC--FSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPG 208
            ..:.|..||....:||..|:|.|||..|  ..||.:.:......:.|||: |:|...|.......
  Fly   187 VPLIYTVNSIHPVIPWMSCNNSWNTQECSLHENYDVDDYRVDPHSTVEFF-RSMIASTAKGSTSM 250

Human   209 QIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPY-----IMLIILFFRGVTLPGAKEGI 268
            .|.|.:.|.:...|::|...:.|.|.:.|||:..|....:     :.|.:|....||.    :.:
  Fly   251 SISWSMLIGVLSIWLVVLALLLKPVAFIGKVLRCSCVLMFGFFVAVFLYLLIHEQVTF----DTL 311

Human   269 LFYITPNFRKLSDSEVWLDAATQIFF---SYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCT 330
            .:|..|...  |...:...|.|.:..   :.|.|.||:|.|.|||:|..:..|.||.| |:...|
  Fly   312 HYYWMPQLD--SFDSILATARTALLMAGGALGPGWGSIITLSSYNNFRRDAERLSIWV-CLTHIT 373

Human   331 SMFAGFVIFSI--------VGFM-AHVTKRSIADVAASGPGLAFLAYPEAVTQLPISP-LWAILF 385
            ....|.:..::        ||.| .||.::....       ..:|.:.....:...:| |||.||
  Fly   374 IGLMGLLCCNVAHDHFEDHVGMMPLHVDEKHHMQ-------FLYLCFSYLFGRFTTTPNLWAFLF 431

Human   386 FSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAV--CIIS---YL---IGLSNITQG 442
            |.|:.:..:.:....:...||||.||: ..||:||.|.|:::  |:.:   |.   :|.|.:||
  Fly   432 FGMIFLSELCALIIQMMSVITALFDEF-ETLRSRRILVISSLVFCLTASSVYFCTQLGFSQLTQ- 494

Human   443 GIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPII 507
             :....:|.:...||:.:|.        .:|.||..||..::|.|:|.....:......|.|||.
  Fly   495 -LPNLAVFTHLLISGILVLM--------TTWVYGRVRFQCDLQFMLGKTISSFKIFFIRFATPIF 550

Human   508 VAGVFIFSAVQMTPLTMGNYVFPK---------WGQGVGWLMALSSMVLIPGYMAYMFLTLKGSL 563
            : |:.:|   |:|      |:|.:         ..||:..|.|:|       ||.|......|..
  Fly   551 L-GLCLF---QLT------YLFTRDRIHDVLIYVSQGLILLTAIS-------YMVYKVCRTNGDW 598

Human   564 KQRIQVMVQPSE 575
            :||:|..:.|.:
  Fly   599 RQRLQQCLAPHD 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	158/597 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599
CG13796	NP_609140.2	SLC5-6-like_sbd	123..610	CDD:444915	145/529 (27%)