Protein Alignment SLC6A1 and CG13795

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_609138.3
• Gene: CG13795 / 34049
• FlyBaseID: FBgn0031937
• Length: 594
• Species: Drosophila melanogaster
• Alignment Length: 586
• Identity: 150/586 - (25%)
• Similarity: 272/586 - (46%)
• Gaps: 92/586 - (15%)

Human    42 PD--RDTWKGRFDFLMSCVGYAIGL----GNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLL 100
            ||  |..|....||:.:|.|.|:.|    .:.|.| :..|..|    ::|||:.:....||:.::
  Fly    16 PDLNRGKWDKPTDFMFACFGLALKLDVFVASFWMF-FDMGILG----ILPYFVYMSIYLVPIMVI 75

Human   101 ECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCD 165
            ...:||::|.|.:..::|:|.|||:|..:..|:..:.|||.:..:..:.::.|||..|||| .|:
  Fly    76 HSFMGQFSSSGFISAFRLSPFFKGMGYVSGFLTISMLIYYSIFAAVPLLFIINSFRPTLPW-SCE 139

Human   166 --NPWNTDRCFSNYSMVNTTNMTSAVVEFWERN-MHQMT------------DGLD--------KP 207
              :.|:.    .:.::.::.|.|..:.:|.|.| .||:.            |.:.        |.
  Fly   140 GLSSWHN----GSATLSSSCNKTLILEDFSEYNRSHQLLHVPSVLYFQNHYDSMQQDAVPDWYKD 200

Human   208 GQIRWPLAITLAIAWILVYFCIWK--GVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILF 270
            .::.|......||.|:::.|..:|  .....||::.:......::|::.|.|.:.||||..|:..
  Fly   201 YELSWHFVGLFAIIWVVIAFIFYKFSETAKFGKLIRYMVIVTLVLLLVCFVRFLFLPGALNGLHR 265

Human   271 YITPNFRKLSDSEVW-LDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFA 334
            |:||   |.||..:. :.....:..::|.|.||:|.|.|:|.|..::...|.|:    |...:|.
  Fly   266 YVTP---KASDMAMGVVSTFIMVLHAFGAGWGSVITLSSFNGFKTDIMSYSWII----SFGQIFI 323

Human   335 GFVIFSIVGFMAHVTKRSIADVAASGPGLA----FLAYPEAVTQLPISPLWAILFFSMLL---ML 392
             :::|.:|.||.......::||..:|..|:    :|:...|::.:....||..:::||||   ::
  Fly   324 -YIMFGMVSFMLEHYFNELSDVDDNGHVLSHWLLYLSSASALSTMAWPNLWTFIYYSMLLIAALI 387

Human   393 GIDSQFCTVEGFITALVDEYPRLLRNRREL---FIAAVCIISYLIGLSNITQGGIYVFKLFDYYS 454
            .:.:|..||   :.:|.||:..|...::|:   .|..:.:.|:..    .|..||..|......:
  Fly   388 VMTTQIFTV---LQSLFDEFEVLRVRKQEVTFGLIGGIALCSFYF----CTNHGIIFFSALGLDA 445

Human   455 ASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKL-CWSFFTPII-----VAGVFI 513
            ....|||.|:..  :.:.|.||..||..:|:.|:| :|...||: ...|..|||     :||:
  Fly   446 IFSHSLLHLLLL--LVVLWIYGRERFQRDIEFMLG-QPFASWKVFILRFIAPIILVICLLAGI-- 505

Human   514 FSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVL----IPGYMAYMFLTLKGSLKQRIQVMVQPS 574
                   .|::..:   .:...|.::|::..:||    ||||..|......|:..:|.:...:|:
  Fly   506 -------ALSISEH---SYSTTVVFVMSIVLVVLPILAIPGYGFYYLYQSTGTFCERFKRTCRPT 560

Human   575 E 575
            :
  Fly   561 D 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	150/586 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599
CG13795	NP_609138.3	SLC5-6-like_sbd	27..505	CDD:271356	132/505 (26%)