Protein Alignment SLC6A1 and CG13793

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_609136.2
• Gene: CG13793 / 34047
• FlyBaseID: FBgn0031935
• Length: 583
• Species: Drosophila melanogaster
• Alignment Length: 597
• Identity: 145/597 - (24%)
• Similarity: 260/597 - (43%)
• Gaps: 97/597 - (16%)

Human    42 PD--RDTWKGRFDFLMSCVGYAIGL----GNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLL 100
            ||  |..|:...|::.:|.|.|:.|    .:.|.|     .|.|...::||.:.::...||:.::
  Fly     8 PDLNRGNWEKPTDYIFACFGLALKLDIFVASFWFF-----FNTGIFGMVPYLMYMVIYLVPIMVI 67

Human   101 ECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCD 165
            ...:||::|.|.:..::|:|:|||:|..:..|:..|.|||.:..:..:.::.|||..|||| .|:
  Fly    68 HSYMGQFSSSGFISAFRLSPLFKGMGYVSLFLTITLLIYYTIFAAVPLLFVLNSFRPTLPW-SCE 131

Human   166 --NPWNTDRCFSNYSMVNTTNMTSAVVE------FWERNMHQ-------------MTDGLDKPGQ 209
              ..|..| ..:.:|:.|.|.......|      |:..|:|.             ..|......:
  Fly   132 GFKSWQND-TIAKWSICNATIAEEVAKETENDTYFYITNIHVPSVLYFKSHFESFQNDSELNDYE 195

Human   210 IRWPLAITLAIAWILVYFCIWK--GVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYI 272
            |.|.|:...|:.|..:.|..:|  .....||.:.:.......:|::.|.|.:.||||..|:..|:
  Fly   196 ISWHLSGLFALVWATIAFIFYKFSEPAKFGKCIRYMVIGTVALLLVCFVRFLFLPGAHLGLKNYM 260

Human   273 TPNFRK--LSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAG 335
            ||:..:  :..|..::.|..    ::|.|.||:|.|.|:|.|..|:...|.|:    |...:|.
  Fly   261 TPSIEEFVVGTSSTFIMALQ----AFGAGWGSVITLSSFNGFKTNIMSYSWII----SFGQIFI- 316

Human   336 FVIFSIVGFM-AHV---TKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLM---LG 393
            :::|.:|.|| .|.   ..:.:.:.......:.||:...|::.|....||..::::||||   :.
  Fly   317 YIMFGMVSFMLEHYFLGLPKPLFETQVINHWVLFLSSASALSSLGWPNLWTFIYYTMLLMAALIV 381

Human   394 IDSQFCTVEGFITALVDEYPRLLRNRRELFIA-----AVCIISYLIGLSNITQGGIYVFKLFDYY 453
            |.:|..|:   :.:|.||:.:|...::|:.:.     |||.:.:      .|..|:..|.:....
  Fly   382 ITTQIFTI---LQSLFDEFEQLRAKKQEVTLGLIGGLAVCSLYF------CTNHGVLYFAILSID 437

Human   454 SASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQ 518
            :....:||.|:..  :.:.|.||.:||..:|:.|:| :|...||:   |....:.....:...|.
  Fly   438 AIFSQTLLHLLLL--LVVLWVYGRDRFQKDIKFMLG-QPFASWKV---FILRFVAPPTLVICLVL 496

Human   519 MTPLTMGNYVFPKWGQGVGWLMAL----SSMVLIPGYMAYMFLTLKGSL---------------- 563
            ...:.:..:   .:...|...||:    ..::.||.|..|......||:
  Fly   497 EIKMCLEEH---SYSSSVLHFMAIILVGLPILAIPAYGFYYIHQRPGSISELFRATDWYPVEMEY 558

Human   564 KQRIQVMVQPSE 575
            :|:...:||.||
  Fly   559 RQQYGELVQKSE 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	145/597 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599
CG13793	NP_609136.2	SLC5-6-like_sbd	19..498	CDD:271356	127/509 (25%)