Protein Alignment SLC6A1 and Ntl

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_609135.1
• Gene: Ntl / 34046
• FlyBaseID: FBgn0267326
• Length: 590
• Species: Drosophila melanogaster
• Alignment Length: 555
• Identity: 219/555 - (39%)
• Similarity: 354/555 - (63%)
• Gaps: 15/555 - (2%)

Human    24 NDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFL 88
            |..|.|...:..|:.....:|..||.:.:|::|.:|||||:||||||||||.::||.||||||.|
  Fly     4 NQPPTTNATRKDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLL 68

Human    89 TLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYN 153
            .:|.||:|||.:|..:||::|.|..|::::.|:.||.|:|..|::.:...||.||||:.|..::.
  Fly    69 MVILAGIPLFYMEILIGQFSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFY 133

Human   154 SFTTTLPWKQCDNPWNTDRCF--SNYSMVNTTNM--TSAVVEFWERNMHQMTDGLDKPGQIRWPL 214
            .|...:||:.|.|.||||.|.  |:....|::::  ||| .||:...:.:::..:...|.:.|..
  Fly   134 CFFKKVPWEDCSNSWNTDDCVTASDMGKQNSSDVFKTSA-DEFFHLEVLRISTDISDLGGMVWEQ 197

Human   215 AITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKL 279
            ...|.|.||::|||:.:|:...||||||:..:||::|.||..||.|||||.:||.||:.|.:.:|
  Fly   198 LTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRL 262

Human   280 SDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGF 344
            .|.:||.|||.|:||..|.|.|.::.:.|::||.||...||:::..||..||:.||||:||::||
  Fly   263 LDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGF 327

Human   345 MAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALV 409
            ::..:...:..||..|.||||:.||||:..||:..|||::||.||.:|||||.|..:|..:::::
  Fly   328 LSEKSGIPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSIL 392

Human   410 DEYPRLLRNRRELFIAAVCIISYLIGLSNI--TQGGIYVFKLFDYYSASGMSLLFLVFFECVSIS 472
            ||:..:..::.:|.:.: |:|  .:|||:|  |.||:::.:|||:|| |.::::.:...|.:.::
  Fly   393 DEWYWVRSHKCKLTLIS-CLI--FLGLSSIMCTNGGMFILQLFDWYS-SAIAVIVICLVEIIMVA 453

Human   473 WFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVG 537
            |.||:..|..:::.|:|.||.::|::.|...||:|:..:.|.|.|.:..:|..|..:|:|...:|
  Fly   454 WIYGIKNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNNIPYPQWAIIIG 518

Human   538 WLMALSSMVLIPGYMAYMFL----TLKGSLKQRIQ 568
            |....:|::.||.|:.|:.:    ||..|||:|::
  Fly   519 WASCFTSVMWIPLYIFYIMIRKRATLCDSLKKRLK 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	219/555 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:444915	215/535 (40%)