Protein Alignment SLC6A1 and ine

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_477012.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Alignment Length: 598
• Identity: 233/598 - (38%)
• Similarity: 365/598 - (61%)
• Gaps: 30/598 - (5%)

Human     2 ATNGSKVADGQISTEVSE----------APVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMS 56
            :|:|.|:...::.|..:|          .|:..|...:.:....:.|...|.:..|..:..|:::
  Fly   285 STDGRKLVIRRVPTTANELFDMVNPQTPPPLGVDDDDSYLDMSDETAQLKPRQQHWANKMQFVLA 349

Human    57 CVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTS---IGGLGVWKL 118
            |:||::||||||||||:|.|:|||.||:||.:.|....:||..:|.|:||||.   ||.||  :|
  Fly   350 CIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALG--QL 412

Human   119 APMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCF------SNY 177
            .|:|||.|||:.|:||.::.||.|||.::|||.:.||.|.:||..|:|.|||..|:      .|.
  Fly   413 CPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRKGINA 477

Human   178 SMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYF 242
            |..:|:...|.  ||:|..:.|::.||:.||.:||.|...|..||::|||..||.:..:.||.||
  Fly   478 SAPDTSRTPSE--EFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYF 540

Human   243 SATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALG 307
            :||:|::::|||..|.|||.||.||:.|:..|.:.:|.::.||::||:|.|.|.|:..||:|:..
  Fly   541 TATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSMISFA 605

Human   308 SYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAV 372
            |||.::||:.||::.|..:|..||:..|...||.:|.:|.....::.||...|||:.|:.||:|:
  Fly   606 SYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGMIFVVYPQAM 670

Human   373 TQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNR---RELFIAAVCIISYLI 434
            .::|.:.|||::||.|||.||::|||..||..:|::.|.:||.::..   .|:.:..||:||.|.
  Fly   671 AKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVLFVCVISCLF 735

Human   435 GLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLC 499
            |:.||.|||||.|:|.|:|:|| ::::||.|.:.::|:||||..|...|:::|.|..|..:.:.|
  Fly   736 GMPNIIQGGIYYFQLMDHYAAS-VTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSC 799

Human   500 WSFFTPIIVAGVFIFSAVQMTPLTM--GNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKG- 561
            |....|.::..:::.|.:.....|.  |.|.:|.|..|:||:.|..|::.||||....||...|
  Fly   800 WLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGD 864

Human   562 SLKQRIQVMVQPS 574
            :..:||:..::|:
  Fly   865 TFWERIRNTLRPN 877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	233/598 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599
ine	NP_477012.1	SLC5-6-like_sbd	337..876	CDD:444915	223/543 (41%)