Protein Alignment SLC6A1 and NAAT1

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_572219.1
• Gene: NAAT1 / 31457
• FlyBaseID: FBgn0029762
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 623
• Identity: 208/623 - (33%)
• Similarity: 335/623 - (53%)
• Gaps: 67/623 - (10%)

Human     3 TNGSKVADGQ-----ISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAI 62
            :|||....|.     .|||.::|    :||..             :|..|....:|||||:..::
  Fly     9 SNGSSNGSGNGATNAASTEKTDA----EKPTA-------------ERTNWGNGLEFLMSCISVSV 56

Human    63 GLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGL 127
            |||||||||:...:||||||||||.:.|...|.|::.||..:||:||.|.:.:|.:.|.|.|||.
  Fly    57 GLGNVWRFPFTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIWSVVPGFVGVGY 121

Human   128 AAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWN----------TDRCFSNYSMVNT 182
            ..|..:..:..||..:::..:|||:.||.:.|||..|.:.|.          .|...:..|:.|.
  Fly   122 GQAFGTICIISYYSSLLALTLYYLFVSFQSELPWSYCRDEWTNCVNSRPQEYVDNLLTGVSLANE 186

Human   183 T--NMTSAVV-----------EFWERNM-----HQMTDGLDKPGQIRWPLAITLAIAWILVYFCI 229
            :  |::..|.           |.:..|:     ..::||:..|.   |.|.:.|.:||::::..|
  Fly   187 SARNLSGIVANDETEKLQSSSELYFLNVVIKEKLDISDGVGDPD---WKLTLALFVAWVVIFLVI 248

Human   230 WKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFF 294
            .:||..:||..||.|.:||::|.:|..|.|||.||::||||::.|.:.:|.:..||.:|..|.||
  Fly   249 MRGVKSSGKAAYFLALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFF 313

Human   295 SYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAH-VTKRSIADVAA 358
            |..:|.|.:|...|||.|.:.:|||::||..:::.||:..|..||:|:|.:|| :...:|.||..
  Fly   314 SLAVGSGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVR 378

Human   359 SGPGLAFLAYPEAVTQLPISP-LWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRREL 422
            ||.||||::||:|:::....| |:::|||.||.:|||.|........:|.:.|:: :..:..:..
  Fly   379 SGTGLAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTIICDQF-KGWKYWKVA 442

Human   423 FIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLF-LVFFECVSISWFYGVNRFYDNIQE 486
            ...:||  .:|:||..:|.||.::..|.|:|  .|..::| |..||...|.|.||:..|.|:|:.
  Fly   443 LTTSVC--GFLMGLVYVTPGGQWILTLVDFY--GGTYVVFILAIFELAGIVWVYGLQNFCDDIEF 503

Human   487 MVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGY 551
            |...|..::|::|||||||:::..:||:|.|.:.|:......||:.....|||:........|.:
  Fly   504 MCNRRVSLYWRVCWSFFTPVMMIIIFIYSMVTIEPIKYSELYFPEAANIAGWLLFAIGAAQFPLW 568

Human   552 -MAYMFLTLKGSLKQRIQVMVQPSEDIVRPENGPEQPQ 588
             :.|:....:|:..:.::..::||:     ..||..|:
  Fly   569 GLWYISRHPQGTYWKSLKASLKPSD-----RWGPANPE 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	208/623 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		3/12 (25%)
		PDZ-binding	597..599
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	181/500 (36%)