Protein Alignment SLC6A1 and CG10804

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_001138150.1
• Gene: CG10804 / 31317
• FlyBaseID: FBgn0029663
• Length: 726
• Species: Drosophila melanogaster
• Alignment Length: 609
• Identity: 239/609 - (39%)
• Similarity: 351/609 - (57%)
• Gaps: 73/609 - (11%)

Human     2 ATNGSKVADG-QISTEVSEAP------VANDKPKTLVVKVQKKAADLPD----------RDTWKG 49
            |||...::|. ..|:|:.:.|      .:..|.|..:|.:...:||..|          |::|..
  Fly    59 ATNQGFMSDAFDESSELEQDPPPFGSEASTSKAKAELVAIATASADQQDIVEGEKEGEERESWDS 123

Human    50 RFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLG 114
            :..||::.:|||:|||||||||||..||||||||:|||:.|...|:|:|.||.::||....|.:|
  Fly   124 KIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGIPIFYLELAIGQRLRKGAIG 188

Human   115 VW-KLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYS 178
            || :::|...|:|:::||:|:.:.:||..||:|.:.||.:||.:.|||..|..     |.:.|::
  Fly   189 VWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESPLPWADCPT-----RLYKNFT 248

Human   179 MVNTTN-MTSAVVEF-WERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVY 241
            ..:... :.|:..:| |.|...|.::.:|.|....:.:||.|.::|.|||.|:.:|:..:||:||
  Fly   249 YDHEPECVASSPTQFYWYRTTLQCSESVDMPENFNYHMAIALIVSWFLVYICMVQGITSSGKIVY 313

Human   242 FSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIAL 306
            .:|.:||::|||.||||:||.||.:|:....||.:..|.|..|||:|.||||||.||..|.|||.
  Fly   314 MTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLLDPVVWLEAGTQIFFSLGLAFGGLIAF 378

Human   307 GSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVT------KRS------------I 353
            .|||..:||.|||:|:|...|..||||||.|:||::||.|..|      :|:            :
  Fly   379 SSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGFKATATFDRCTEERNGLVAQNKTHNLPV 443

Human   354 ADV------AASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDE- 411
            .|:      :|||.||||:.:.||:.|.|.:.|||:|||.||..|||||||.|:||.:|:|||.
  Fly   444 CDLQTELANSASGTGLAFIIFTEAINQFPGAQLWAVLFFLMLFTLGIDSQFGTLEGVVTSLVDMK 508

Human   412 -YPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFY 475
             :|.|   .:|..:.|:|.....|.:......|.|:|:|.|.: |....||.:..|||:|||:.|
  Fly   509 LFPNL---PKEYIVGALCFSCCTISMCFANGAGSYIFQLMDSF-AGNFPLLIIALFECLSISYIY 569

Human   476 GVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKW------GQ 534
            ||.||.|:|:.|.||||..:|..||.:.:|..:..:.:.|..|:  ||.|: .:|.|      .:
  Fly   570 GVRRFSDDIEMMTGSRPNFYWMFCWKYLSPCAMVTILLASFYQL--LTEGS-SYPAWIGSKGATE 631

Human   535 GVGW---------LMALSSMVLIP 549
            |:.|         .:.|||::.||
  Fly   632 GMEWPHWCIVVAFFLILSSILWIP 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	239/609 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	225/548 (41%)