Protein Alignment SLC6A1 and CG33296

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_995644.2
• Gene: CG33296 / 2768941
• FlyBaseID: FBgn0053296
• Length: 585
• Species: Drosophila melanogaster
• Alignment Length: 564
• Identity: 149/564 - (26%)
• Similarity: 264/564 - (46%)
• Gaps: 59/564 - (10%)

Human    42 PDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQ 106
            |.|..|:...|:|.:|.|.|:.| :::...|....|.|...::||||.::...||:.::...:||
  Fly    18 PKRGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVVHSFMGQ 81

Human   107 YTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCD--NPWN 169
            ::|.|.:..::|||:|||:|..:..|:|...|||.:.::..:.:|.|||..|||| .|:  ..|:
  Fly    82 FSSSGFIAAFRLAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPW-SCEGLKSWH 145

Human   170 --TDR----C-------FSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPL--AITLA 219
              ||.    |       ..||::     ...|....:...:.|.....||...|..||  ..||:
  Fly   146 NRTDEYPTLCHPTIYKQHENYTL-----GVEAPSRLYFDYIRQDYFNTDKRFDISRPLIGLFTLS 205

Human   220 IAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDS-- 282
            .|.|.:.|..:......||.:.:......:::::.|.|.:.|||:.:.:..|||||.:..|:.
  Fly   206 WALIAIIFYHFSEPAKFGKCIRYMVITTMVLVVVCFVRFLFLPGSHKLLWMYITPNTKDFSEGIY 270

Human   283 EVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAH 347
            ..::.|..    ::|.|.||:|||.|:|.|..::...|.|:    |...:|. :::|.:|.||..
  Fly   271 STFIMALQ----AFGAGWGSVIALSSFNGFKTDIMSYSWII----SFGQIFI-YIMFGLVSFMLE 326

Human   348 VTKRSIADVAA----SGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLG---IDSQFCTVEGFI 405
            ...:.|:|...    ....:.||:...|:..|....||..:::||||:..   |.:|..||   :
  Fly   327 QYYKDISDTIVFHRIMNFWVLFLSSASALNTLGWPNLWTFIYYSMLLLASLTVIATQLFTV---L 388

Human   406 TALVDEYPRLLRNRRELFIAAVC---IISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFE 467
            .:|.||:.:|...::|:....:|   |.|:..    .|:.|.:.|.:.........|||.|:..
  Fly   389 QSLFDEFEKLKERKQEVTFGIICGLAICSFFF----CTEHGSFYFAILGIDVILAHSLLHLLLL- 448

Human   468 CVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFT-PIIVAGVFIFSAVQMTPLTMGNYVFPK 531
             :.:.|.||..||..:|:.|:| :|...||:....:| ||:.....|...::...:   ::.|.:
  Fly   449 -LVVLWIYGQKRFQRDIEFMLG-QPFASWKVFILRYTAPIVFLICMILGIIECIRV---HFFFKE 508

Human   532 WGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSE 575
            ....:|.::.:...:.||||..|......|:..:|::...:|::
  Fly   509 VFLVLGIILVVLPFLAIPGYGFYYLRQSPGTFLERLKRSCRPTD 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	149/564 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599
CG33296	NP_995644.2	SLC5-6-like_sbd	27..496	CDD:271356	136/494 (28%)