Protein Alignment SLC6A1 and snf-11

DIOPT Version :10

• Sequence 1: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_505873.2
• Gene: snf-11 / 191770
• WormBaseID: WBGene00004910
• Length: 610
• Species: Caenorhabditis elegans
• Alignment Length: 588
• Identity: 299/588 - (50%)
• Similarity: 417/588 - (70%)
• Gaps: 47/588 - (7%)

Human    37 KAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLE 101
            :|..:.:|:.|....||:|||:||||||||||||||||.:||||||||||.::|:|.|.|||:||
 Worm     3 EATSVAEREQWSSWADFIMSCIGYAIGLGNVWRFPYLCYQNGGGAFLIPYCISLVFCGAPLFILE 67

Human   102 CSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFT-TTLPWKQCD 165
            .|.||..|:||||::|:.|:|||||:||||::|||||||||::|||..||||||| :.:|||.||
 Worm    68 TSWGQLMSVGGLGMFKICPIFKGVGIAAAVMAFWLNIYYIVVLSWAATYLYNSFTMSDVPWKNCD 132

Human   166 NPWNTDRCFSNYSMV----NTT--------------------------------------NMTSA 188
            :.|||..|.|.|..:    |.|                                      ::.|.
 Worm   133 HAWNTPNCRSEYVKIPCDSNRTIAEFFNVKVLTHDHIHEYKKQFFVGEKMNWTVCSAADLSVVSP 197

Human   189 VVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLII 253
            |.|||...:..::.||:.||.|||.||:.|.:.||:.|.||:|||.|||||||.:|::||:||..
 Worm   198 VKEFWNHRVLGISSGLENPGGIRWDLALFLLLVWIICYLCIFKGVKWTGKVVYITASFPYMMLFC 262

Human   254 LFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYR 318
            |..||:||.||..|:.||:.|:|.||.:|:||:||.||:|||||||||:|:||||||.|:||||:
 Worm   263 LLIRGLTLEGAGVGLEFYLKPDFSKLLESKVWVDAVTQVFFSYGLGLGALVALGSYNKFNNNVYK 327

Human   319 DSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAI 383
            .::.||.:||.||:||||||||.:||||...::|:|:||.:||||.|||||..:.|||.:..|:.
 Worm   328 QALTVCFVNSGTSVFAGFVIFSFIGFMATQQEKSVAEVAQAGPGLLFLAYPSGILQLPYTQFWSC 392

Human   384 LFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNR--RELFIAAVCIISYLIGLSNITQGGIYV 446
            |||.|:|.||:||||||:|||.||::||:|::.|.:  ||:|:..:|:|||||||:.:|:||.||
 Worm   393 LFFLMVLFLGVDSQFCTMEGFFTAIIDEFPQIRRKKYGREIFVGVICVISYLIGLTTVTEGGFYV 457

Human   447 FKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGV 511
            |:|||:|:|||.:||:|:||||::|||..|::|:|::::.|:|..|..|||.||.|.||.:..||
 Worm   458 FQLFDFYAASGWALLWLLFFECIAISWSLGIDRWYEHMKSMIGYYPSAWWKFCWVFATPSVCFGV 522

Human   512 FIFSAVQMTPLTMG--NYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPS 574
            .:|..::..||.:.  ||.:|.||...||.::||||:.||||..:::....|:::::|:::.:|.
 Worm   523 LLFGLIKYQPLRIDAYNYDYPVWGHIFGWFLSLSSMLCIPGYAIWIWFKTPGTVQEKIKLLCRPD 587

Human   575 EDI 577
            .:|
 Worm   588 IEI 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	299/588 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		1/1 (100%)
		PDZ-binding	597..599
snf-11	NP_505873.2	SLC6sbd-TauT-like	10..586	CDD:271387	296/575 (51%)