Protein Alignment SLC6A1 and XB5944457

DIOPT Version :9

• Sequence 1: NP_001335179.1
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_001106493.1
• Gene: XB5944457 / 100127682
• XenbaseID: XB-GENE-5944458
• Length: 599
• Species: Xenopus tropicalis
• Alignment Length: 599
• Identity: 541/599 - (90%)
• Similarity: 571/599 - (95%)
• Gaps: 0/599 - (0%)

Human     1 MATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLG 65
            |||||:||||||||||||||||.||||||||||||||..:..:||||||||||||||||||||||
 Frog     1 MATNGTKVADGQISTEVSEAPVTNDKPKTLVVKVQKKKTEEVERDTWKGRFDFLMSCVGYAIGLG 65

Human    66 NVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAA 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog    66 NVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAA 130

Human   131 VLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWER 195
            ||||||||||||||:|||||||||||||||||.|||.|||:|||||||:.|||||||||||||||
 Frog   131 VLSFWLNIYYIVIIAWAIYYLYNSFTTTLPWKHCDNSWNTERCFSNYSIANTTNMTSAVVEFWER 195

Human   196 NMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVT 260
            |||||||||:|||||||||||||||||:||||||||||||||||||||||||||||:||||||||
 Frog   196 NMHQMTDGLEKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLVILFFRGVT 260

Human   261 LPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCC 325
            ||||.:||||||||.|.|||||||||||||||||||||||||||||||||.||||||||||||||
 Frog   261 LPGALDGILFYITPKFSKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNRFHNNVYRDSIIVCC 325

Human   326 INSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLL 390
            ||||||||||||||||||||||||||.|..|||||||||||||||||||||||||||:|||||||
 Frog   326 INSCTSMFAGFVIFSIVGFMAHVTKRPIEQVAASGPGLAFLAYPEAVTQLPISPLWAVLFFSMLL 390

Human   391 MLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSA 455
            |||||||||||||||||||||:|:|||.|||:|||.||::|||:|||||||||||||||||||||
 Frog   391 MLGIDSQFCTVEGFITALVDEFPKLLRTRREIFIAVVCVVSYLVGLSNITQGGIYVFKLFDYYSA 455

Human   456 SGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMT 520
            |||||||||||||:||||.||||||||||:||||.||||||||||||||||||||||:|||||||
 Frog   456 SGMSLLFLVFFECISISWCYGVNRFYDNIEEMVGYRPCIWWKLCWSFFTPIIVAGVFLFSAVQMT 520

Human   521 PLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDIVRPENGPE 585
            |||||:||||.|||||||.|||||||||||||.|:||:||||||||:|||:||:|::||.|||||
 Frog   521 PLTMGSYVFPSWGQGVGWFMALSSMVLIPGYMVYLFLSLKGSLKQRLQVMIQPTEEVVRSENGPE 585

Human   586 QPQAGSSTSKEAYI 599
            |....:|.:|||||
 Frog   586 QLSQSNSANKEAYI 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A1	NP_001335179.1	SLC6sbd_GAT1	2..599	CDD:212075	538/596 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		12/21 (57%)
		PDZ-binding	597..599		1/1 (100%)
XB5944457	NP_001106493.1	SLC6sbd_GAT1	2..599	CDD:212075	538/596 (90%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1017	1.000	Domainoid score	I626
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2290
Inparanoid	1	1.050	1141	1.000	Inparanoid score	I2449
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D124278at7742
OrthoFinder	1	1.000	-	-		FOG0000575
OrthoInspector	1	1.000	-	-		oto154412
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3352
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060