DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A5 and CG2187

DIOPT Version :9

Sequence 1:	XP_011526494.1	Gene:	SLC5A5 / 6528	HGNCID:	11040	Length:	654	Species:	Homo sapiens
Sequence 2:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster

Alignment Length:	618	Identity:	198/618 - (32%)
Similarity:	312/618 - (50%)	Gaps:	58/618 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    12 FGAWDYGVFALMLLVSTGIGLWVGLARGGQRSAEDFFTGGRRLAALPVGLSLSASFMSAVQVLGV 76
            ||..||.||.:||..|.|||::.|.....:.:.|::..||:::..||:.:||.||.:|.:.::.:
  Fly    24 FGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQLSGIAIMSI 88

Human    77 PSEAYRYGLKFLWMCLGQLLNSVLTALLFMPVFYRLGLTSTYEYLEMRFSRAVRLCGTLQYIVAT 141
            |:|:|.||..::::.|..|:...:...:.:||||...:::.||||||||::..|...|..::..:
  Fly    89 PAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQLVTFFFVTNS 153

Human   142 MLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTFYTAVGGMKAVVWTDVFQVVVMLSGFWVVL 206
            .|...:.::.|:|...||||::|....:....||.|||.:||:||||||||.|..:||.....|.
  Fly   154 FLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIMLLSVVAVG 218

Human   207 ARGVMLVGGPRQVLTLAQNHSRINLMDFNPDPRSRYTFWTFVVGGTLVWLSMYGVNQAQVQRYVA 271
            ..|.:..||...|:..|.:..|.| .||..|||.|.|||...:||..:|....|:||:.|||.|:
  Fly   219 VLGTIRSGGMFTVMERASDGGRFN-FDFGLDPRIRMTFWGATMGGIFMWTGHIGLNQSCVQRIVS 282

Human   272 CRTEKQAKLALLINQVGLFLIVSSAACCGIVMFVFYTDCDPLLLGRISAPDQLSGRLTPSSPQYM 336
            ..:...||.:|:::.:|..:|.......||:||..|..|||:|.|.:|.||::           |
  Fly   283 LPSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARYYGCDPMLAGLVSKPDKM-----------M 336

Human   337 PLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRLRSLAPR-----KLVI 396
            |..|.||...|.|:||:|::|.:|..||:.|.::|::|.|...|.||||:|....|     ||::
  Fly   337 PFFVQDIMGHLAGMPGVFISCVFSAALSSLSATLNSLAGVVYFDYIKPRIRHTEARANWAMKLIV 401

Human   397 ISKGLSLIYGSACLTVAALSSLLGG-------GVLQGSFTVMGVISGPLLGAFILGMFLPACNTP 454
            :      :.|..|        :|||       .:||...|:.|:.:|.::|.|:||||:|.||..
  Fly   402 V------VMGGYC--------ILGGFMVQNFNSILQTVVTITGINTGAVVGVFLLGMFVPRCNAK 452

Human   455 GVLAGLGAGLALSLW-VALGATLYPPSEQTMRVLPSSAARCVA--LSVNASGLLDPALLPANDSS 516
            ..:..:...:...:| :|.|...:........|||:|..:|.|  |.:.|..:......|.   :
  Fly   453 TAVTSIIVSVVAMVWIIANGQMNFKSGLIKYEVLPNSLDQCEARGLYMIAEAINKTDFTPV---T 514

Human   517 RAPSSGMDASRPALAD---SFYAISYLYYGALGTLTTVLCGALISCLTGPTKRSTLAPGLLWWDL 578
            ..|.||...:....:|   |.|.||:.:|..||:....||...:|.:..|.:.....| .|:...
  Fly   515 MKPPSGAPVTTAFHSDRDFSLYDISFYWYKVLGSALVFLCAIPLSYIWRPDENEKQNP-KLYSPF 578

Human   579 ARQTASVAPKEEVAILDDNLVKGPEELPTGNKK 611
            .|:..|      :.:.|.:|    ||:|....|
  Fly   579 VRKFLS------LPVTDQDL----EEVPLRGSK 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A5	XP_011526494.1	SLC5sbd_NIS	15..565	CDD:271393	186/567 (33%)
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	185/562 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146396
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5313
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.800