Protein Alignment SLC5A5 and CG5687

DIOPT Version :10

• Sequence 1: XP_011526494.1
• Gene: SLC5A5 / 6528
• HGNCID: 11040
• Length: 654
• Species: Homo sapiens
• Sequence 2: NP_647678.3
• Gene: CG5687 / 38255
• FlyBaseID: FBgn0035293
• Length: 683
• Species: Drosophila melanogaster
• Alignment Length: 560
• Identity: 183/560 - (32%)
• Similarity: 309/560 - (55%)
• Gaps: 26/560 - (4%)

Human     2 EAVETGERPTFGAWDYGVFALMLLVSTGIGLWVGLARGGQRSAEDFFTGGRRLAALPVGLSLSAS 66
            |......:.||..:||.:...||::|.|||::.|..:.|..|:.:|..|. .::..||.|||:.|
  Fly    86 ECSAPSHKATFSGYDYVILLGMLVISLGIGIFYGFFQKGGSSSNEFLLGS-EMSIFPVTLSLTTS 149

Human    67 FMSAVQVLGVPSEAYRYGLKFLWMCLGQLLNSVLTALLFMPVFYRLGLTSTYEYLEMRFSRAVRL 131
            |::|:::||.|||.|..|.:|:.:.:..::...:...:|.|:::::.|||.||||.:||.:.:|:
  Fly   150 FITAIELLGNPSEMYFQGTQFVLIVIPMVIVIPVAVKIFYPIYFKMELTSCYEYLGIRFGKEIRI 214

Human   132 CGTLQYIVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTFYTAVGGMKAVVWTDVFQVV 196
            .|.:.|::....||.:.:.|||:.|::.||||...:::...::|.||::.|||||||..|.||..
  Fly   215 LGAVLYVIQMCFYTAVAVLAPAIALSKATGLDTKIAVVLIYVVCVFYSSQGGMKAVVIADSFQAA 279

Human   197 VMLSGFWVVLARGVMLVGGPRQVLTLAQNHSRINLMDFNPDPRSRYTFWTFVVGGTLVWLSMYGV 261
            |:.....:::..|....|.|.||...|.:|:|:...:.:|||.:|:|.|:.|:||...|.|::..
  Fly   280 VLAVSLVLIVGLGCFYSGNPIQVFQTASDHNRLEFFNMDPDPTTRHTVWSVVIGGFFYWTSLFCT 344

Human   262 NQAQVQRYVACRTEKQAKLALLINQVGLFLIVSSAACCGIVMFVFYTDCDPLLLGRISAPDQLSG 326
            |||.||:.::.::.:.||:||....:||.::.......|:::|..|.|||||..|||||.|||
  Fly   345 NQASVQKCMSLKSLRLAKIALGFAIIGLIVVFLLNFYTGLMVFTHYADCDPLTAGRISATDQL-- 407

Human   327 RLTPSSPQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRLR-SLA 390
                     :|..|::.:|.:..|.|:|:|..::.:|.|.::::|:::|||.|||:...:. .::
  Fly   408 ---------LPYYVINTYEHISSVAGIFVAGIFAASLGTVASALNSLSAVTCEDLLVNGMNIKIS 463

Human   391 PRKLVIISKGLSLIYGSACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFILGMFLPACNTPG 455
            |.|....:|.:||.:|.|...:..:...| |||||.:.|:.|:|.|..||.|:||:.....||.|
  Fly   464 PEKGATYAKWMSLGFGIASFGLVFIVEHL-GGVLQATLTLNGLIGGVTLGLFVLGIACKQANTKG 527

Human   456 VLAGLGAGLALSLWVALGATLYPPSEQTMRVLPSSAARCVALSVNASGLLDPALLPANDSSRAPS 520
            ...|....|||.::|.:.|.:....:.   .||:|..:| ...||.:.::...|   .:......
  Fly   528 AFYGGLLSLALVIFVGVVAQIVSVEQP---ALPTSIDKC-DCHVNMTNIIGSLL---TEPLEVIE 585

Human   521 SGMDASRPALADSFYAISYLYYGALGTLTTVLCGALISCL 560
            .|...|.|     .:.:||::|..:|.|.||..|..||.:
  Fly   586 EGGFTSWP-----IFRLSYMWYSMIGCLLTVFLGWFISLI 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A5	XP_011526494.1	SLC5sbd_NIS	15..565	CDD:271393	180/547 (33%)
CG5687	NP_647678.3	SLC5sbd_NIS-SMVT	99..620	CDD:271383	180/545 (33%)