DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A5 and CG5687

DIOPT Version :9

Sequence 1:	XP_011526494.1	Gene:	SLC5A5 / 6528	HGNCID:	11040	Length:	654	Species:	Homo sapiens
Sequence 2:	NP_001286910.1	Gene:	CG5687 / 38255	FlyBaseID:	FBgn0035293	Length:	683	Species:	Drosophila melanogaster

Alignment Length:	560	Identity:	183/560 - (32%)
Similarity:	309/560 - (55%)	Gaps:	26/560 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     2 EAVETGERPTFGAWDYGVFALMLLVSTGIGLWVGLARGGQRSAEDFFTGGRRLAALPVGLSLSAS 66
            |......:.||..:||.:...||::|.|||::.|..:.|..|:.:|..|. .::..||.|||:.|
  Fly    86 ECSAPSHKATFSGYDYVILLGMLVISLGIGIFYGFFQKGGSSSNEFLLGS-EMSIFPVTLSLTTS 149

Human    67 FMSAVQVLGVPSEAYRYGLKFLWMCLGQLLNSVLTALLFMPVFYRLGLTSTYEYLEMRFSRAVRL 131
            |::|:::||.|||.|..|.:|:.:.:..::...:...:|.|:::::.|||.||||.:||.:.:|:
  Fly   150 FITAIELLGNPSEMYFQGTQFVLIVIPMVIVIPVAVKIFYPIYFKMELTSCYEYLGIRFGKEIRI 214

Human   132 CGTLQYIVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTFYTAVGGMKAVVWTDVFQVV 196
            .|.:.|::....||.:.:.|||:.|::.||||...:::...::|.||::.|||||||..|.||..
  Fly   215 LGAVLYVIQMCFYTAVAVLAPAIALSKATGLDTKIAVVLIYVVCVFYSSQGGMKAVVIADSFQAA 279

Human   197 VMLSGFWVVLARGVMLVGGPRQVLTLAQNHSRINLMDFNPDPRSRYTFWTFVVGGTLVWLSMYGV 261
            |:.....:::..|....|.|.||...|.:|:|:...:.:|||.:|:|.|:.|:||...|.|::..
  Fly   280 VLAVSLVLIVGLGCFYSGNPIQVFQTASDHNRLEFFNMDPDPTTRHTVWSVVIGGFFYWTSLFCT 344

Human   262 NQAQVQRYVACRTEKQAKLALLINQVGLFLIVSSAACCGIVMFVFYTDCDPLLLGRISAPDQLSG 326
            |||.||:.::.::.:.||:||....:||.::.......|:::|..|.|||||..|||||.|||
  Fly   345 NQASVQKCMSLKSLRLAKIALGFAIIGLIVVFLLNFYTGLMVFTHYADCDPLTAGRISATDQL-- 407

Human   327 RLTPSSPQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRLR-SLA 390
                     :|..|::.:|.:..|.|:|:|..::.:|.|.::::|:::|||.|||:...:. .::
  Fly   408 ---------LPYYVINTYEHISSVAGIFVAGIFAASLGTVASALNSLSAVTCEDLLVNGMNIKIS 463

Human   391 PRKLVIISKGLSLIYGSACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFILGMFLPACNTPG 455
            |.|....:|.:||.:|.|...:..:...| |||||.:.|:.|:|.|..||.|:||:.....||.|
  Fly   464 PEKGATYAKWMSLGFGIASFGLVFIVEHL-GGVLQATLTLNGLIGGVTLGLFVLGIACKQANTKG 527

Human   456 VLAGLGAGLALSLWVALGATLYPPSEQTMRVLPSSAARCVALSVNASGLLDPALLPANDSSRAPS 520
            ...|....|||.::|.:.|.:....:.   .||:|..:| ...||.:.::...|   .:......
  Fly   528 AFYGGLLSLALVIFVGVVAQIVSVEQP---ALPTSIDKC-DCHVNMTNIIGSLL---TEPLEVIE 585

Human   521 SGMDASRPALADSFYAISYLYYGALGTLTTVLCGALISCL 560
            .|...|.|     .:.:||::|..:|.|.||..|..||.:
  Fly   586 EGGFTSWP-----IFRLSYMWYSMIGCLLTVFLGWFISLI 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A5	XP_011526494.1	SLC5sbd_NIS	15..565	CDD:271393	180/547 (33%)
CG5687	NP_001286910.1	SLC5sbd_NIS-SMVT	99..620	CDD:271383	180/545 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.920