DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A5 and CG31668

DIOPT Version :9

Sequence 1:	XP_011526494.1	Gene:	SLC5A5 / 6528	HGNCID:	11040	Length:	654	Species:	Homo sapiens
Sequence 2:	NP_001097055.2	Gene:	CG31668 / 33395	FlyBaseID:	FBgn0051668	Length:	590	Species:	Drosophila melanogaster

Alignment Length:	621	Identity:	191/621 - (30%)
Similarity:	302/621 - (48%)	Gaps:	74/621 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    12 FGAWDYGVFALMLLVSTGIGLWVGLARG----------------------GQRSAEDFFTGGRRL 54
            ||..||.||..:.::|..|||:.|..|.                      |.:...|:..|.|.|
  Fly     6 FGTVDYAVFLGVTILSIAIGLYFGFIRKSRNGPKTTTPTNEAPERRHQNFGSKKMNDYMMGSRNL 70

Human    55 AALPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLLNSVLTALLFMPVFYRLGLTSTYE 119
            ...|||:||.||.:|||.::|.|||.|.||.::.::.:..:|..:..:.:::|||..|.:||:||
  Fly    71 RVFPVGMSLIASCISAVAIIGTPSEIYNYGTQYCFIVIALVLQGLAVSYIYLPVFSALQVTSSYE 135

Human   120 YLEMRFSRAVRLCGTLQYIVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTFYTAVGGM 184
            ||||||..|:|...::.:|:..:||...:.|.|||.||||:|::::.......:||..||.:||:
  Fly   136 YLEMRFHSAIRSIVSIIFILDVVLYLPFLAYLPALALNQVSGMNMYLIEAFIIVICVIYTVLGGL 200

Human   185 KAVVWTDVFQVVVMLSGFWVVLARGVMLVGGPRQVLTLAQNHSRINLMDFNPDPRSRYTFWTFVV 249
            ||||.||::|||:|.:....::......:......|.......|:...:.||.|.:|:|.|:.|:
  Fly   201 KAVVHTDIWQVVIMFASVLTIVVLATCYIDDQADFLEGLVRGGRLIFSETNPSPFARHTVWSVVI 265

Human   250 GGTLVWLSMYGVNQAQVQRYVACRTEKQAKLALLINQVGLFLIVSSAACCGIVMFVFYTDCDPLL 314
            |.|..|.|:..|:|..|.||::..|.|.|:.::....||....:|.....|:::|..|.|||||.
  Fly   266 GNTFYWTSLNAVHQTVVHRYMSLPTLKMARASIAFLVVGAAFFISLLCYLGLLIFHAYRDCDPLS 330

Human   315 LGRISAPDQLSGRLTPSSPQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVE 379
            .|.|...|||           :||.|::....:.|:||||:|..:..:||:.|..:|:.:.|.::
  Fly   331 AGLIMNDDQL-----------VPLFVVNSLGHVYGMPGLFIAGIFGASLSSLSVYLNSTSLVILQ 384

Human   380 DLIKPRLR-SLAPRKLVIISKGLSLIYG-SACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAF 442
            ||::...: .|......|:.||..::.| .|...|..|..:  .|||..|.::..:.:....|.|
  Fly   385 DLVRGCFKMELGEWASTIVVKGSIVVLGLLAFAMVFVLEKV--SGVLSISVSLAAIAASSTFGIF 447

Human   443 ILGMFLPACNTPGVLAGLGAGLALSLWVALGATLYPPSEQT-MRVLPSSAARCVALSVNAS---- 502
            .:||.:|..||.|...|..|.:.|:.|::.|:.....|.|. .:.||.|...|:|   |||
  Fly   448 TVGMLVPWANTVGTAVGGIASVLLTGWISFGSQFAAASGQLGSQRLPVSVEGCLA---NASVAEN 509

Human   503 -GLLDPALLPANDSSRAPSSGMDASRPALADSFYAISYLYYGALGTLTTVLCGALISCLTGPTKR 566
             .:.:..:.|                      .|.:||.:...:|.||.|:.|:|:|.:|.||..
  Fly   510 AWVAEEEVFP----------------------LYRLSYHWISPIGVLTVVVVGSLVSLVTKPTDI 552

Human   567 STLAPGLLWWDLARQTASVAPKE--EVAILDDNLVK 600
            .:|...|:...:.|    ..|||  |....::|.||
  Fly   553 KSLDSDLITPVIHR----FLPKECFEQGNAEENSVK 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A5	XP_011526494.1	SLC5sbd_NIS	15..565	CDD:271393	178/579 (31%)
CG31668	NP_001097055.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	169/559 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146435
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.850