DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A4 and CG32669

DIOPT Version :9

Sequence 1:	XP_016884409.1	Gene:	SLC5A4 / 6527	HGNCID:	11039	Length:	689	Species:	Homo sapiens
Sequence 2:	NP_727460.1	Gene:	CG32669 / 326229	FlyBaseID:	FBgn0052669	Length:	604	Species:	Drosophila melanogaster

Alignment Length:	575	Identity:	126/575 - (21%)
Similarity:	229/575 - (39%)	Gaps:	94/575 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    47 WSGSKLSVPVLLSETPTKRHGPLASHNHSAMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGS 111
            |..:.|:|.:::|         :|...:...:...:.|...:.||.|.|...|:..||.||.:.:
  Fly     7 WDYTILAVVLIIS---------VAIGIYYRFVGGKQSTTTEYLLADRSMNVAPVAFSLMASFMSA 62

Human   112 NHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFG-GERLQVYL 175
            ...:|::......|...|....:..:...:..::.:|::.:....::.|||:.||| ..||   .
  Fly    63 VTILGVSMENYQYGTMFVVINLSYVLSTPVAAYLIIPVFYRLKTASVYEYLELRFGYATRL---A 124

Human   176 SILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTII 240
            :.||..:.:||.:...::|.|:.::...||....:|.|:..:...|.|.||:.:|:.||..|:::
  Fly   125 ASLSFSLQMVLYMGIVVYAPALALEAVTGLSQVFSIVIVGVVCTFYATLGGMKAVLITDIYQSLL 189

Human   241 MLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLTISASCYTPRADSFHIFRDAVTGDIP 305
            |....|.::..|:.:.|..|....         |..:|..|:.:.::......|          .
  Fly   190 MFAAVFSVIICAWVKAGSLEVIWR---------VAQENGRINLTNFSVDPTERH----------T 235

Human   306 WPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYT 370
            |...|.|...|.|..:..||..|||.:..|.:|..:||...|..:..|........|:.....|.
  Fly   236 WFTQILGGCATYLAIYGVNQTQVQRLMAVKSLSAARAALWWCLPILCLLSLSTCFSGLCIYWYYR 300

Human   371 DMVACVVPSECVKHCGVDVGCTNYAYPTMVLELMPQ--GLRGLMLSVMLASLMSSLTSIFNSAST 433
            |         |.......|...:...|..|::.|.:  ||.||.:|.:..:.:|:::||.:|.:.
  Fly   301 D---------CDPLLEGRVNSRDQVMPLFVVDTMGEYTGLAGLFVSGIFCASLSTISSIISSLAA 356

Human   434 LFTIDLYTK------MRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSY 492
            : |::.|.|      .::..::::.|...::..|....:.|...  ......|.|:....||...
  Fly   357 V-TLEDYLKPLVSCCAKRTLTDRQTLWYSKLLSLFFGALCIGMA--FMAGSIGGLLQAALSIFGI 418

Human   493 LGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYGTGSCLAP--------SNCP- 548
            :|.|:..:|.|.::..:.||:||..||::.||..       |..|.|....|        :.||
  Fly   419 IGGPLLGLFTLGMYVTKANEKGAIGGLLISLAFC-------FWIGFGQPKPPLVSLDMSTAGCPV 476

Human   549 ----------KIICGV----HYLYF------------SIVLFFGSMLVTLGISLL 577
                      |.:..|    ||.|.            .::.|||..|::...:||
  Fly   477 DRSFARDIFLKTVIAVAEEEHYFYLYRISYMWYAALGFLITFFGGWLLSWLFALL 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A4	XP_016884409.1	None
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	124/569 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810