Protein Alignment WNK3 and Wnk

DIOPT Version :10

• Sequence 1: NP_065973.2
• Gene: WNK3 / 65267
• HGNCID: 14543
• Length: 1800
• Species: Homo sapiens
• Sequence 2: NP_001262171.2
• Gene: Wnk / 40391
• FlyBaseID: FBgn0037098
• Length: 2462
• Species: Drosophila melanogaster
• Alignment Length: 2163
• Identity: 572/2163 - (26%)
• Similarity: 853/2163 - (39%)
• Gaps: 571/2163 - (26%)

Human     3 TDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKE---KNSTFSASGETVERKRFFRKSVE 64
            |.:...|:...|....|| .:|.:.:.:.:||:|....:   |:||..:||  |:|..|   .||
  Fly   330 TPTRSNATDATSHHVAGI-IDNIITEASRSLTIEKTEDDVPLKSSTKHSSG--VKRVGF---QVE 388

Human    65 MTEDDKV------------------AESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSK 111
            ..:|.:|                  :|:|.::..:..:........|||..|            .
  Fly   389 DKDDTEVQSEKQAKSFDDITKKAESSEASAEEAAVTGSSTDASASPLPSTSL------------V 441

Human   112 STSEISKDCFKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWC 176
            ||:..:....|.|::::.:      .||.||.|||.|:|.|:|||:|||||:||||.|.|.||||
  Fly   442 STTSSATSITKSKSDEDDD------PVAMSPCGRFFKYDKEVGRGSFKTVYRGLDTLTGVPVAWC 500

Human   177 ELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR 241
            ||.|:::.|:|:.||:|||:|||.||||||||||..||..:..||.||||||||.|||||:||||
  Fly   501 ELLDKQVKKSERTRFREEADMLKKLQHPNIVRFYTYWEFPIGRKKNIVLVTELMLSGTLKSYLKR 565

Human   242 FKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFA 306
            ||.:.||||:||||||||||.|||||..||||||||||||||||.||||||||||||||...|.|
  Fly   566 FKKIHPKVLKSWCRQILKGLNFLHTRQFPIIHRDLKCDNIFITGTTGSVKIGDLGLATLKNRSHA 630

Human   307 KSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFN 371
            ||||||||||||||||||||||||||||||||||||.||||||||:..||||:||.||||||:..
  Fly   631 KSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMAISEYPYSECKGPAQIYKKVISGIKPAALA 695

Human   372 KVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVE-LAEEDDCSNSSLAL---RLWV 432
            ||.||.|::|||.||...|.:|.|..:||...||.||.|:||| .|.|...|:.|:::   ||..
  Fly   696 KVEDPNVRDIIERCIELKKEDRPSCNELLESEFFDEDIGIRVEPTASEQFLSDPSISIIEFRLRF 760

Human   433 EDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREK 497
            .||||...:||:||||:|.:|:..|..|::|.||:|.....|.||:|||:.::.:|..:.|.|.:
  Fly   761 MDPKKRSSRHKENEAIQFEYNIRHDEYEQIAQEMMKENIISEDDSRAVARLLKVQVVSLLKERAQ 825

Human   498 KPAGCLEERRDSQCKSMGNVFPQPQNTTLPL----APAQQTGAECEETEVDQHVRQQLLQRKPQQ 558
            :......:...|:.:.:.   .|.|..:||.    ...::..:|.||..|..:.|.||..
  Fly   826 RQTQIKLQNEKSRLEKLA---LQKQRESLPTNVDEDEEEEEESEDEEDGVKWNQRLQLRY----- 882

Human   559 HCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSN----QTMGSQMVSNIP----QAEVNVPGQIY 615
                   |.|           :|.|:.|:|.|:|    |.:.::..::||    |..|.||||:.
  Fly   883 -------DLL-----------NTDSETSLALSTNSVEPQQLSTRSNTSIPNSGIQQPVQVPGQVP 929

Human   616 SSQQL------------------VGHYQQVSGLQKH-------SKLTQPQILPLVQGQSTVLPVH 655
            .||.:                  ..||.|...|..:       .::|..|::.....|.......
  Fly   930 VSQLISVQPQAIPSPAIPMQQKPTVHYIQPPQLASYQNSNASMQEMTNNQVISPTGSQQMQQQQP 994

Human   656 VLGPTV---------VSQPQVSPLTVQKVPQIKPVSQPVGA------EQQAALLKPDLVRSLNQD 705
            |:.|||         |:|.|..|..:|::||...|.||...      |||....:..|.:.|.|.
  Fly   995 VVAPTVNHQVMPQQQVNQQQQQPQMMQQIPQQVQVQQPQTVLPPQPHEQQPQQQQQPLQQQLQQL 1059

Human   706 VATTKENVSSPDNPSGNGKQDRIKQRRA------SCPRPEKGTKFQ------------------- 745
            :.|   ||.:||..    :|.::.|::|      ...:|::....|
  Fly  1060 MHT---NVQAPDLT----QQQQMAQQQAQQYFQQQQQQPQQAVNMQQAYAMQQAGQQQQLSQPLQ 1117

Human   746 -----LTVLQVSTSGDNMV-ECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLES------ 798
                 |...||:.|....: :.||..|..:.:         ..:.:....::....::.
  Fly  1118 IQQQILQQQQVAVSHQQQIMQQQLAQHQLQQL---------QQQQLQQQQLQQQQQIQQQQLQQQ 1173

Human   799 --EKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSSQTGSSEQVQINSTST-----Q 856
              ::::||::....:.|.|.       .:..||...:....:........|:|:..||.     .
  Fly  1174 QLQQQQFVQQYAQAMPQQQH-------QQLVTGSQVMAPHQHQQPIQIPVQMQVPPTSVAPPIQH 1231

Human   857 TSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPG------RHPLPSPKNTSNKEIS 915
            |.|:...|            .|:.:.:.|..|    ..||||.      :.|...|...| ..:.
  Fly  1232 TYNQQGGQ------------VTLSDAQQQQHP----GFSAVPQQAAPFIQQPTQQPIQLS-MPLE 1279

Human   916 RDTLLTIENNPCHRALFTSKSEHKDVVDGK------------ISECASVETKQPAILYQ---VED 965
            :.....:.:.|..:....|:.:.:.:|..:            ..:...|:.:||::.:|   |:.
  Fly  1280 QQLQQLLHSQPAQQQQAMSQQQQQPLVQQQQLPLVQQQPPLVQQQQPLVQHQQPSVQHQQPLVQQ 1344

Human   966 NRQIMAPVTNS----SSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSHPGESTQ 1026
            .:|......|.    .:..|..|:..|.:.:...:|.|......|..|...|  .:..:...:..
  Fly  1345 PQQQQPQPQNQQPQPQTQQTHVVQQQPPQQQPAVEQISQISSQVPVQQENLQ--PIQVNKDANVA 1407

Human  1027 TSGNSLTTL--AFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTPGLEPTTLQP 1089
            |...||.:.  |.:..|:|    :|...|:...|:.:|...|.:..|:
  Fly  1408 TDAMSLNSAHGALEPAPKT----EPQNSADAEKQQKQTGTGTRSQKPR----------------- 1451

Human  1090 TTVLESDGERPPKLEFA------------DNRIKTLDEKL-----------RNLLYQE------- 1124
             ....|..||.|||...            :|::||:..|.           ..|:.|:
  Fly  1452 -RSNRSGNERIPKLSVTSVDEGSVINCHMENKLKTITFKFDIGDVNPVEIANKLIAQDLLSNCQS 1515

Human  1125 ----HSISSIYPESQKDTQSIDSP---------------------FSS-----SAEDTLSCPVTE 1159
                ..|:.|..:.:::...|..|                     |.|     |.::|.| .:|:
  Fly  1516 TVFVEMINEIVDQVKQNPNQIPIPTNYRRNIEKVRHASLTRQRSTFRSHQRHRSRDETAS-DITK 1579

Human  1160 VIAISHCGIKDSPVQSPNFQQTGSKL-------LSNVA-ASQPANISVFKRDLNVITSVPSELCL 1216
            :...:..|::..|......:|:...|       |||:. |.:|        .|||.|. |:....
  Fly  1580 MFEPTIHGVETLPSGGGGAEQSNCNLTLEARSHLSNIPNAKEP--------QLNVSTP-PTTTST 1635

Human  1217 HEMSSDASLPGDPEAYPAAVSSGGAIH-LQTGGGYFGLSFTC------------PSLKNPISKKS 1268
            ...||.||......:....:.||.... ..|...|..||...            |.|.:...||.
  Fly  1636 MSSSSTASRDAPNSSNDVTIGSGSVSRKTSTASEYTSLSIDYMPDSNITPTGPEPPLDDGKDKKP 1700

Human  1269 WTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTR-----ESTADTRALNRCKAM 1328
            .:..:......|..:.:...||.                .:||.|     |....||:|:...|:
  Fly  1701 CSLAIARMQKLLESAGNGAPRSL----------------NLPLNRHLKIQEDLKHTRSLDDLTAV 1749

Human  1329 SGSF--------------QRGRFQVITIPQQQSAKM-------TSFGIEHISVFSETNHSSEEAF 1372
            ..:|              |:........|:.:|.:.       .:..:|.:.:..| |.:...||
  Fly  1750 KITFDMPNKAALDTSENAQQATEAEAEKPKDKSGQAVGNQGTGAANTLEQLKIELE-NITHAHAF 1813

Human  1373 IKTAKSQLVEIEPATQNPKTSFSYEKLQA------LQETCKENKG----VPKQGDN--------- 1418
            .....:.:....|...:|..|    .|:|      .||..|.|.|    ||..|.|
  Fly  1814 ASAVVASINNRAPHQASPAMS----SLKATSGQPQTQEITKPNNGAGPSVPSVGQNTPTAALTSA 1874

Human  1419 -----------------------FLSFSAACETDVSSVTP---EKEFEETSATGSSMQSGSELLL 1457
                                   .|..:...|..||:..|   |.....|.|||...|...:..|
  Fly  1875 RGSGSSVYNSRRTSIDNSVGSDMHLHTATNLEGTVSNPDPIPTEASVGITIATGHEKQLSKQPSL 1939

Human  1458 KE---REILTAG-----KQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHHEEQAYA-----QTQ 1509
            ::   ..|||..     :.||:.|....|:|...|.:|......|.     ||.|.|     ..|
  Fly  1940 EKPSATSILTNNSDPPQRNPSNGSINQNSIADLEKKLAALRNTENT-----EESATATLSVVPKQ 1999

Human  1510 SSLFYSPSS-PMSSDDESEIEDE------------DLKVELQRL-------REKHIQ--EVVNLQ 1552
            .....:||: .:|....|.::::            .||::||..       ....:|  .|||..
  Fly  2000 VEEVVNPSARKISRFSVSRVQEQKTSTGVEEPAQGQLKIDLQVAGPGGQVQTNNSVQNGSVVNTP 2064

Human  1553 TQ------QNKEL-----QELYERLRSIKD-----SKTQS---TEIPLPP-------ASPRRPRS 1591
            |:      ||..|     |.:|::.:.|..     |.|.|   |:..:.|       ...::|.:
  Fly  2065 TEVISSPIQNVPLAINGIQLMYQQPQQIHQLPGGTSTTTSGAGTQCIVVPQVVNQNGTHVQQPSN 2129

Human  1592 FKSKLRSRPQSLTHVDNGIVATGKSCLINELEN----------------------PLCVESNAAS 1634
            .:.:.:|...::|.........|...::|.|:.                      |:..:.....
  Fly  2130 LQPQQQSVHPNMTQQPQQTPLNGHPSMVNTLQQQPPQQSLPMQTIQSQQQQHNQMPIISQQQQQQ 2194

Human  1635 C----QQSPASKKG--MFT------------------DDLHKLVDDWTKEAVGN--------SLI 1667
            .    ||...|::|  .|.                  :.||.|.......|.||        ..:
  Fly  2195 ILMQQQQQQGSQQGSQQFNLPGTQQTHPQHQFIQSQPNQLHSLPPQVVSMAQGNLPHQLPPMQTM 2259

Human  1668 KPSLNQLKQSQHKLETENWNKVSENTPSTMG-YTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPL 1731
            ......:.|.||:|:.:: :...:|.|.... .|...:::.....||||..|.|...|.:...|
  Fly  2260 GAQQQMISQQQHQLQMQS-HMHQQNVPGMYNQQTGARVAAPQNFAGAVPNHLLQQSPLMASQQP- 2322

Human  1732 SSYGMPHVCQ--YNAVAG 1747
             :..|.||.|  :||.:|
  Fly  2323 -AQPMQHVMQPIFNATSG 2339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WNK3	NP_065973.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		5/21 (24%)
		STKc_WNK3	136..410	CDD:270933	200/273 (73%)
		OSR1_C	426..489	CDD:463491	26/65 (40%)
		Interaction with KLHL3. /evidence=ECO:0000305|PubMed:35179207	537..547		4/9 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	707..739		8/37 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	834..868		7/38 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	880..912		9/37 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1060..1086		3/25 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1431..1453		8/24 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1465..1496		8/35 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1571..1600		7/43 (16%)
Wnk	NP_001262171.2	STKc_WNK	469..729	CDD:270885	191/259 (74%)
		OSR1_C	754..816	CDD:463491	26/61 (43%)
		DUF5585	1789..2159	CDD:465521	75/379 (20%)