Protein Alignment WNK4 and GAL11

DIOPT Version :10

• Sequence 1: XP_016880451.1
• Gene: WNK4 / 65266
• HGNCID: 14544
• Length: 1302
• Species: Homo sapiens
• Sequence 2: NP_014591.1
• Gene: GAL11 / 854106
• SGDID: S000005411
• Length: 1081
• Species: Saccharomyces cerevisiae
• Alignment Length: 810
• Identity: 143/810 - (17%)
• Similarity: 245/810 - (30%)
• Gaps: 267/810 - (32%)

Human   485 AEEVAQEMVALGLVCEADYQPVARAVRERVAAIQRKREKLRKARELEALPPEPGPPPATVPMAPG 549
            |:..||...|.....:|..|..|:|..:..|..|.:.:...:|:.......:|...|......|.
Yeast   435 AQAQAQAQAAQAAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAHAQHQPSQQPQQAQQQPN 499

Human   550 PPSVFPPEPEEPEADQHQPFLFRHASYSSTTSDCETDGYLSSSGFLDASDPALQPPGGVPSSLAE 614
            |.....|                      |..|.|....||    ||||...|:
Yeast   500 PLHGLTP----------------------TAKDVEVIKQLS----LDASKTNLR----------- 527

Human   615 SHLCLPSAFALSIPRSGPGSDFSPGDSYASDAASGLSDVGEGMGQMRRPPGRNLRRRPRSRLRVT 679
                                        .:|..:.||:..:...:|:...|:.|      .::|:
Yeast   528 ----------------------------LTDVTNSLSNEEKEKIKMKLKQGQKL------FVQVS 558

Human   680 SVSDQNDRVVECQLQTHNSKMVTFRFDL------------DG------DSPEEIAAAMVYNEFIL 726
            :.:.|      ..:.|.|...:...|.|            :|      |:.:.:  .:.|.:: .
Yeast   559 NFAPQ------VYIITKNENFLKEVFQLRIFVKEILEKCAEGIFVVKLDTVDRL--IIKYQKY-W 614

Human   727 PSERDGFLRRIREIIQRVETLLKRDTGP----------MEAAEDTLSPQEEPAPLPALPVPLPDP 781
            .|.|...||| :.|:::.:.:...:..|          :...::.....::...|..|.:.....
Yeast   615 ESMRIQILRR-QAILRQQQQMANNNGNPGTTSTGNNNNIATQQNMQQSLQQMQHLQQLKMQQQQQ 678

Human   782 SNEELQSSTSLEHRSWTAFSTSSSSPGTPLSPGNPFSPGTPISPGPIFPITSPPCHPSPSPFSPI 846
            ..::.|.....:.:........||:||.........:||..|                  |:
Yeast   679 QQQQQQQQQQQQQQQQQQHIYPSSTPGVANYSAMANAPGNNI------------------PY--- 722

Human   847 SSQVSSNPSPHPTSSPLPFSSS---TPEFPVPLSQCPWSSLPTTSPPTFSPTCSQVTLSSPFFPP 908
                    ..|..:|.:.|.:|   ||:.||..:..|  ||..|.....:......|:
Yeast   723 --------MNHKNTSSMDFLNSMENTPKVPVSAAATP--SLNKTINGKVNGRTKSNTI------- 770

Human   909 CPSTSSFPSTTAAPLLSLASAFSLAVMTVAQSLLSPSPGLLSQSPPAPPSPLPSLPLPPPVAPGG 973
             |.| |.|||...  ||:::|.|          ..|:|...|.:..:.|:..|| ||......|
Yeast   771 -PVT-SIPSTNKK--LSISNAAS----------QQPTPRSASNTAKSTPNTNPS-PLKTQTKNG- 819

Human   974 QESPSPHTAEVESEASPPPARP----------LPGEARLAPISEEGKPQLVGRFQVTSSKEPAEP 1028
              :|:|:  .:::..||..|:|          ...|..|....|..|.::..||:.........|
Yeast   820 --TPNPN--NMKTVQSPMGAQPSYNSAIIENAFRKEELLLKDLEIRKLEISSRFKHRQEIFKDSP 880

Human  1029 LPL---------------QPTSPTL----------SGSPKPSTPQLTSESSDTED---------- 1058
            :.|               ..||.|:          ||..||:.....:...|:.|
Yeast   881 MDLFMSTLGDCLGIKDEEMLTSCTIPKAVVDHINGSGKRKPTKAAQRARDQDSIDISIKDNKLVM 945

Human  1059 -SAGGGPETREALAESDRAA--EGLGAGVEEEGDDGKEPQVGGSPQPLSHPSPVWMNYSYSSLCL 1120
             |.........::|.|:.||  :|:|...::                            .|:|..
Yeast   946 KSKFNKSNRSYSIALSNVAAIFKGIGGNFKD----------------------------LSTLVH 982

Human  1121 SSEESESSGEDEEFWAELQSLRQKHLSEVETLQTLQKKEIEDLYS------------RLGKQPPP 1173
            ||..|.||..|      :.:.|::..|   .|:...:..|..:.|            ::.....|
Yeast   983 SSSPSTSSNMD------VGNPRKRKAS---VLEISPQDSIASVLSPDSNIMSDSKKIKVDSPDDP 1038

Human  1174 GIVAPAAMLSSRQRRLSKGSFPTSRRNSLQ 1203
            .:....|..|.:|...::..|.||..:|.|
Yeast  1039 FMTKSGATTSEKQEVTNEAPFLTSGTSSEQ 1068

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WNK4	XP_016880451.1	STKc_WNK4	172..432	CDD:270935
		OSR1_C	453..515	CDD:463491	8/29 (28%)
		PHA03247	<798..1074	CDD:223021	65/324 (20%)
GAL11	NP_014591.1	KIX_2	9..80	CDD:465331
		gal11_coact	170..232	CDD:418417
		Med15_fungi	509..620	CDD:398846	26/168 (15%)