Protein Alignment WNK4 and Wnk

DIOPT Version :10

• Sequence 1: XP_016880451.1
• Gene: WNK4 / 65266
• HGNCID: 14544
• Length: 1302
• Species: Homo sapiens
• Sequence 2: NP_001262171.2
• Gene: Wnk / 40391
• FlyBaseID: FBgn0037098
• Length: 2462
• Species: Drosophila melanogaster
• Alignment Length: 1360
• Identity: 381/1360 - (28%)
• Similarity: 571/1360 - (41%)
• Gaps: 330/1360 - (24%)

Human   104 EPPEGTWTEGAPVKAAEDSARPELPDSAVGPGSREPLRVPEAVALERRREQEEKEDMETQAVATS 168
            |..|.:..|.|...::.|::...||.:::...:.....:.::           |.|.:...||.|
  Fly   412 ESSEASAEEAAVTGSSTDASASPLPSTSLVSTTSSATSITKS-----------KSDEDDDPVAMS 465

Human   169 PDGRYLKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNI 233
            |.||:.|:|.|:||||||||||||||.|.|.||||||..:::.::||.||.||.:|||.||||||
  Fly   466 PCGRFFKYDKEVGRGSFKTVYRGLDTLTGVPVAWCELLDKQVKKSERTRFREEADMLKKLQHPNI 530

Human   234 VRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPI 298
            ||||..|:..:..:..||||||||.|||||:||:||:::.|:||:.|.||||:||:|||:|..||
  Fly   531 VRFYTYWEFPIGRKKNIVLVTELMLSGTLKSYLKRFKKIHPKVLKSWCRQILKGLNFLHTRQFPI 595

Human   299 LHRDLKCDNVFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGM 363
            :||||||||:||||.|||||||||||||||..|.||||||||||||||||||.|||:||||||||
  Fly   596 IHRDLKCDNIFITGTTGSVKIGDLGLATLKNRSHAKSVIGTPEFMAPEMYEEHYDESVDVYAFGM 660

Human   364 CMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEIIEGCIRTDKNERFTIQDLLA 428
            ||||||.||||||||:..||||:||.||.||.:..||:.|.|::|||.||...|.:|.:..:||.
  Fly   661 CMLEMAISEYPYSECKGPAQIYKKVISGIKPAALAKVEDPNVRDIIERCIELKKEDRPSCNELLE 725

Human   429 HAFFREERGVHVE-LAEEDDGEKPGLKL---WLR-MEDARRGGRPRDNQAIEFLFQLGRDAAEEV 488
            ..||.|:.|:.|| .|.|.....|.:.:   .|| |:..:|..|.::|:||:|.:.:..|..|::
  Fly   726 SEFFDEDIGIRVEPTASEQFLSDPSISIIEFRLRFMDPKKRSSRHKENEAIQFEYNIRHDEYEQI 790

Human   489 AQEMVALGLVCEADYQPVARAVRERVAAIQRKR----------------EKLRKARELEALPPEP 537
            ||||:...::.|.|.:.|||.::.:|.::.::|                |||...::.|:|
  Fly   791 AQEMMKENIISEDDSRAVARLLKVQVVSLLKERAQRQTQIKLQNEKSRLEKLALQKQRESL---- 851

Human   538 GPPPATVPMAPGPPSVFPPEPEEPEADQ-------HQPFLFRHASYSSTTSDCETDGYLSSSGF- 594
                        |.:|...|.||.|::.       :|....|   |....:|.||...||::..
  Fly   852 ------------PTNVDEDEEEEEESEDEEDGVKWNQRLQLR---YDLLNTDSETSLALSTNSVE 901

Human   595 -------LDASDP--ALQPPGGVPSSLAESHL------CLPSAFALSIPRSGPGSDFSPGD--SY 642
                   .:.|.|  .:|.|..||..:..|.|      .:||. |:.:.:........|..  ||
  Fly   902 PQQLSTRSNTSIPNSGIQQPVQVPGQVPVSQLISVQPQAIPSP-AIPMQQKPTVHYIQPPQLASY 965

Human   643 ASDAAS--------GLSDVGEGMGQMRRP---PGRNLRRRPRSRLRVTSVS-------------- 682
            .:..||        .:|..|....|.::|   |..|.:..|:.::......
  Fly   966 QNSNASMQEMTNNQVISPTGSQQMQQQQPVVAPTVNHQVMPQQQVNQQQQQPQMMQQIPQQVQVQ 1030

Human   683 ---------------DQNDRVVECQLQ------------THNSKMVTFR----FDLDGDSPEEIA 716
                           .|..:.::.|||            |...:|...:    |......|::
  Fly  1031 QPQTVLPPQPHEQQPQQQQQPLQQQLQQLMHTNVQAPDLTQQQQMAQQQAQQYFQQQQQQPQQ-- 1093

Human   717 AAMVYNEFILPSERDGFLRRIREIIQRVETLLKRDTGPMEAAEDTLSPQEEPAPLPALPVPLPDP 781
            |..:...:.:  ::.|..:::.:.:|..:.:|::....:...:..:  |::.|......:.....
  Fly  1094 AVNMQQAYAM--QQAGQQQQLSQPLQIQQQILQQQQVAVSHQQQIM--QQQLAQHQLQQLQQQQL 1154

Human   782 SNEELQSSTSLEHRSWTAFSTSSSSPGTPLSPGNPFSPGTPISPGPIFPITSPPCHPSPSPFSPI 846
            ..::||....::.:................:...|......:..|
  Fly  1155 QQQQLQQQQQIQQQQLQQQQLQQQQFVQQYAQAMPQQQHQQLVTG-------------------- 1199

Human   847 SSQVSSNPSPHPTSSPLPFSSSTPEFPVPLSQCPWSSLPTTSPP---TFSPTCSQVTLSSPFFPP 908
             |||.   :||....|:       :.||.:...|.|    .:||   |::....|||||......
  Fly  1200 -SQVM---APHQHQQPI-------QIPVQMQVPPTS----VAPPIQHTYNQQGGQVTLSDAQQQQ 1249

Human   909 CPSTSSFPSTTAAPLLSLAS----AFSLAVMTVAQSLLSPSPG---------------------L 948
            .|..|:.|. .|||.:...:    ..|:.:....|.||...|.                     |
  Fly  1250 HPGFSAVPQ-QAAPFIQQPTQQPIQLSMPLEQQLQQLLHSQPAQQQQAMSQQQQQPLVQQQQLPL 1313

Human   949 LSQSPP-----------APPS-----PLPSLPLPPPVAPGGQESPSPHTAEVESEASPPPARPLP 997
            :.|.||           ..||     ||...|......|..|: |.|.|.:.......||.:. |
  Fly  1314 VQQQPPLVQQQQPLVQHQQPSVQHQQPLVQQPQQQQPQPQNQQ-PQPQTQQTHVVQQQPPQQQ-P 1376

Human   998 GEARLAPISEEGKPQLVGRFQVTSSKEPAEPLPLQPTSPTLSGS-----------PKPST-PQLT 1050
            ...:::.||.          ||...:|..:|:.:...:...:.:           |.|.| ||.:
  Fly  1377 AVEQISQISS----------QVPVQQENLQPIQVNKDANVATDAMSLNSAHGALEPAPKTEPQNS 1431

Human  1051 SESSDTEDSAGGGPETREALAESDRAAE----GLGAGVEEEG------------------DDGK- 1092
            :::...:...|.|..:::. ..|:|:..    .|.....:||                  |.|.
  Fly  1432 ADAEKQQKQTGTGTRSQKP-RRSNRSGNERIPKLSVTSVDEGSVINCHMENKLKTITFKFDIGDV 1495

Human  1093 EP------------------------------QVGGSPQPLSHPSPVWMNY-------SYSSLCL 1120
            .|                              ||..:|..:    |:..||       .::||..
  Fly  1496 NPVEIANKLIAQDLLSNCQSTVFVEMINEIVDQVKQNPNQI----PIPTNYRRNIEKVRHASLTR 1556

Human  1121 SSEESESSGEDEEFWAELQSLRQKHLSEVETLQTLQKKEIEDLYSRLGKQPPPGIVAPAAMLS-S 1184
            ......|              .|:|.|..||...:.|. .|.....:...|..|..|..:..: :
  Fly  1557 QRSTFRS--------------HQRHRSRDETASDITKM-FEPTIHGVETLPSGGGGAEQSNCNLT 1606

Human  1185 RQRRLSKGSFPTSRRNSLQRSEPPGPGIMRRNSLSGSSTGSQE-QRASKGVTF-AGDVGR 1242
            .:.|....:.|.::...|..|.||    ...:::|.|||.|:: ..:|..||. :|.|.|
  Fly  1607 LEARSHLSNIPNAKEPQLNVSTPP----TTTSTMSSSSTASRDAPNSSNDVTIGSGSVSR 1662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WNK4	XP_016880451.1	STKc_WNK4	172..432	CDD:270935	173/259 (67%)
		OSR1_C	453..515	CDD:463491	20/65 (31%)
		PHA03247	<798..1074	CDD:223021	61/331 (18%)
Wnk	NP_001262171.2	STKc_WNK	469..729	CDD:270885	173/259 (67%)
		OSR1_C	754..816	CDD:463491	20/61 (33%)
		DUF5585	1789..2159	CDD:465521