Protein Alignment WNK4 and Wnk4

DIOPT Version :10

• Sequence 1: XP_016880451.1
• Gene: WNK4 / 65266
• HGNCID: 14544
• Length: 1302
• Species: Homo sapiens
• Sequence 2: XP_006247340.1
• Gene: Wnk4 / 287715
• RGDID: 631401
• Length: 1285
• Species: Rattus norvegicus
• Alignment Length: 1294
• Identity: 1096/1294 - (84%)
• Similarity: 1132/1294 - (87%)
• Gaps: 23/1294 - (1%)

Human     1 MLASPATETTVLMSQTEADLALRPPPPLGTAGQPRLGPPPRRARRFSGKAEPRPRSSRLSRRSSV 65
            |||...|||.|.||||||||||||.|.|.:.|..||||||||.|||||||||||||||.||||||
  Rat     1 MLAPRNTETGVHMSQTEADLALRPSPSLTSMGPTRLGPPPRRVRRFSGKAEPRPRSSRPSRRSSV 65

Human    66 DLGLLSSWSLPASPAPDPPDPPDSAGPGPARSPPPSSKEPPEGTWTEGAPVKAAEDSARPELPDS 130
            |||||||||.|||..|:||||||||  ||.||||.:|||.||||||..|||||| |||.|||..|
  Rat    66 DLGLLSSWSQPASLLPEPPDPPDSA--GPMRSPPSNSKEHPEGTWTGAAPVKAA-DSACPELTVS 127

Human   131 AVGPGSREPLRVPEAVALERRREQEEKEDMETQAVATSPDGRYLKFDIEIGRGSFKTVYRGLDTD 195
            :.|||||||.|||:|.|.|||||||||||.|||||||||||||||||||||||||||||||||||
  Rat   128 SGGPGSREPPRVPDAAARERRREQEEKEDTETQAVATSPDGRYLKFDIEIGRGSFKTVYRGLDTD 192

Human   196 TTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSG 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   193 TTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSG 257

Human   261 TLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLA 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||
  Rat   258 TLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPSGSVKIGDLGLA 322

Human   326 TLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTS 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   323 TLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTS 387

Human   391 GRKPNSFHKVKIPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREERGVHVELAEEDDGEKPGLKL 455
            |.|||||:|||:|||||||||||||||||||||||||.|||||||||||||||||||||||||||
  Rat   388 GTKPNSFYKVKMPEVKEIIEGCIRTDKNERFTIQDLLTHAFFREERGVHVELAEEDDGEKPGLKL 452

Human   456 WLRMEDARRGGRPRDNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVARAVRERVAAIQRK 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   453 WLRMEDARRGGRPRDNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVARAVRERVAAIQRK 517

Human   521 REKLRKARELEALPPEPGPPPATVPMAPGPPSVFPPEPEEPEADQHQPFLFRHASYSSTTSDCET 585
            |||||||||||.|||:.|||||||.|.|||||.||||||||||||||.|||||||||||||||||
  Rat   518 REKLRKARELEVLPPDSGPPPATVSMTPGPPSAFPPEPEEPEADQHQSFLFRHASYSSTTSDCET 582

Human   586 DGYLSSSGFLDASDPALQPPGGVPSSLAESHLCLPSAFALSIPRSGPGSDFSPGDSYASDAASGL 650
            ||||||||||||||||||||||:|||.||.||||||.||||||||||||||||||||||||||||
  Rat   583 DGYLSSSGFLDASDPALQPPGGMPSSPAEPHLCLPSGFALSIPRSGPGSDFSPGDSYASDAASGL 647

Human   651 SDVGEGMGQMRRPPGRNLRRRPRSRLRVTSVSDQNDRVVECQLQTHNSKMVTFRFDLDGDSPEEI 715
            ||:||| ||||:.|.:.|||||||||||||||||:||||||||||||||||||||||||||||||
  Rat   648 SDMGEG-GQMRKNPVKTLRRRPRSRLRVTSVSDQSDRVVECQLQTHNSKMVTFRFDLDGDSPEEI 711

Human   716 AAAMVYNEFILPSERDGFLRRIREIIQRVETLLKRDTGPMEAAEDTLSPQEEPAPLPALPVPLPD 780
            |||||||||||||||||||.||||||||||||||||.||.||.||.||||||||.:||    ||.
  Rat   712 AAAMVYNEFILPSERDGFLSRIREIIQRVETLLKRDAGPSEATEDALSPQEEPAAMPA----LPG 772

Human   781 PSNEELQSSTSLEHRSWTAFSTSSSSPGTPLSPGNPFSPGT-PISPGPIFPITSPPCHPSPSPFS 844
            ||:.|||.|.|.|.|||.|||||.||||||||||.|||||| |:.|.||||||||.|||.|
  Rat   773 PSDAELQRSISPEQRSWAAFSTSPSSPGTPLSPGTPFSPGTPPVFPCPIFPITSPSCHPYP---- 833

Human   845 PISSQVSSNPSPHPTSSPLPFSSSTPEFPVPLSQCPWSSLPTTSPPTFSPTCSQVTLSSPFFPPC 909
              .|||||||.|...||.||.||...:.|.|.     .||||:||..|||:..||.|.....|.|
  Rat   834 --FSQVSSNPCPQAPSSLLPSSSGASQVPFPS-----PSLPTSSPLPFSPSYPQVPLHPASLPTC 891

Human   910 PSTSSFPSTTAAPLLSLASAFSLAVMTVAQSLLSPSPGLLSQSPPAPPSPLPSLPLPPPVAPGGQ 974
            ||....||||||||||||||||||||||||||||||||||||||||||.||||:||  |:|...|
  Rat   892 PSPPPLPSTTAAPLLSLASAFSLAVMTVAQSLLSPSPGLLSQSPPAPPGPLPSMPL--PLASCDQ 954

Human   975 ESPSPHTAEVESEASPPPARPLPGEARLAPISEEGKPQLVGRFQVTSSKEPAEPLPLQPTSPTLS 1039
            ||.|..|||.|:|||..||:||.|:||||||||||||||||||||||||||||| ||||.|||||
  Rat   955 ESLSAQTAETENEASRNPAQPLLGDARLAPISEEGKPQLVGRFQVTSSKEPAEP-PLQPASPTLS 1018

Human  1040 GSPKPSTPQLTSESSDTEDSAGGGPETREALAESDRAAEGLGAGVEEEGDDGKEPQVGGSPQPLS 1104
            .|.|..|||||||||||||||.||||||||||||||||||||..::||.|:|||||:|||...||
  Rat  1019 RSLKLPTPQLTSESSDTEDSAAGGPETREALAESDRAAEGLGVAIDEEKDEGKEPQIGGSSPILS 1083

Human  1105 HPSPVWMNYSYSSLCLSSEESESSGEDEEFWAELQSLRQKHLSEVETLQTLQKKEIEDLYSRLGK 1169
            .||||||||||||||||||||||||||||||||||:||||||||||.||||||||||||||||||
  Rat  1084 QPSPVWMNYSYSSLCLSSEESESSGEDEEFWAELQNLRQKHLSEVEALQTLQKKEIEDLYSRLGK 1148

Human  1170 QPPPGIVAPAAMLSSRQRRLSKGSFPTSRRNSLQRSEPPGPGIMRRNSLSGSSTGSQEQRASKGV 1234
            ||||||||||||||.|||||||||||||||||||||:.|||||||||||||||||||||||||||
  Rat  1149 QPPPGIVAPAAMLSCRQRRLSKGSFPTSRRNSLQRSDLPGPGIMRRNSLSGSSTGSQEQRASKGV 1213

Human  1235 TFAGDVGRMVRAGPREGEPREWYLAAASPSSHLGGFFITFSFPSSEFRTEAMYLPHTRA 1293
            |||||||||||.||:.|........::|.....|.||.||.|||||||.|.:.||:|||
  Rat  1214 TFAGDVGRMVRGGPKGGRAEGMVAGSSSAFLFFGHFFSTFLFPSSEFRPEVLCLPNTRA 1272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WNK4	XP_016880451.1	STKc_WNK4	172..432	CDD:270935	254/259 (98%)
		OSR1_C	453..515	CDD:463491	61/61 (100%)
		PHA03247	<798..1074	CDD:223021	199/276 (72%)
Wnk4	XP_006247340.1	STKc_WNK4	169..429	CDD:270935	254/259 (98%)
		OSR1_C	450..512	CDD:463491	61/61 (100%)