Protein Alignment WNK4 and wnk4

DIOPT Version :10

• Sequence 1: XP_016880451.1
• Gene: WNK4 / 65266
• HGNCID: 14544
• Length: 1302
• Species: Homo sapiens
• Sequence 2: XP_002932565.2
• Gene: wnk4 / 100497207
• XenbaseID: XB-GENE-981916
• Length: 1582
• Species: Xenopus tropicalis
• Alignment Length: 1630
• Identity: 729/1630 - (44%)
• Similarity: 892/1630 - (54%)
• Gaps: 441/1630 - (27%)

Human     5 PATETTVLMSQTEADL-----ALRP--PPPLGTAGQPRLGPPPRRARRFSGKAEPRPRSSRLSRR 62
            ||.:|   |||||.||     |..|  |..|.|..:       .|.||.||| |||..|.:.:||
 Frog     7 PAAQT---MSQTEVDLSGCGIAFLPEDPAELSTLAE-------LRRRRLSGK-EPRRNSYQFNRR 60

Human    63 SSVDLGLL---------SSWSLPASPAPDPPDP-PDSAGPGPARSPP----PSSKEPPEGTWTEG 113
            ||..|.||         |:||      |:.|.| .:...|....||.    ||:...|:......
 Frog    61 SSAQLELLGYDPPGTSFSAWS------PEEPTPLGEIVVPILEMSPNTTCCPSTNAEPDCLLPSV 119

Human   114 APVKAAEDSARP-ELPDSAVGPGSREPLRVPEAVALERRREQEEKEDMETQAVATSPDGRYLKFD 177
            ...|...||:.. :...|..||.:    ..|:......|||.||.|:.||:|||||||||||||:
 Frog   120 ELSKTTVDSSESGDEASSTKGPST----PAPKPALAGNRRELEEIEENETKAVATSPDGRYLKFN 180

Human   178 IEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKS 242
            ||||||||||||:||||:|||||||||||||||::|||||||||||||||||||||||||||||:
 Frog   181 IEIGRGSFKTVYKGLDTETTVEVAWCELQTRKLTKAERQRFSEEVEMLKGLQHPNIVRFYDSWKT 245

Human   243 VLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDN 307
            .::||:||||||||||||||||||:||:|||.:||||||||||:||||||:|.|||:||||||||
 Frog   246 TVKGQICIVLVTELMTSGTLKTYLKRFKEMKLKVLQRWSRQILKGLHFLHTRCPPIIHRDLKCDN 310

Human   308 VFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCMLEMATSE 372
            :|||||||.||||||||||||.|||||||||||||||||||||||||||||||||||||||||||
 Frog   311 IFITGPTGFVKIGDLGLATLKSASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCMLEMATSE 375

Human   373 YPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREERG 437
            |||||||||||||||||||.||:||:|||:||:|||||||||.:||||:||||||.|:||:|:.|
 Frog   376 YPYSECQNAAQIYRKVTSGMKPDSFYKVKVPELKEIIEGCIRMNKNERYTIQDLLEHSFFQEDTG 440

Human   438 VHVELAEEDDGEKPGLKLWLRMEDARR-GGRPRDNQAIEFLFQLGRDAAEEVAQEMVALGLVCEA 501
            |||||||||||.||.|||||||:|.:: .|:.:||.||||||:|.:|.|||||||||.|..:|||
 Frog   441 VHVELAEEDDGIKPALKLWLRMDDTKKLHGKYKDNNAIEFLFELYKDIAEEVAQEMVVLNFICEA 505

Human   502 DYQPVARAVRERVAAIQRKREKLRKARE----------------LEALPPEPGPPPATV-PMAPG 549
            ||:.||:|:|:||.:|:|||||:|:|.|                |:.|.......|:.: .:|||
 Frog   506 DYKLVAKAIRDRVLSIKRKREKVRRAHEELNKKEEEKQQNILKLLDQLRGSQNSTPSPISDVAPG 570

Human   550 PPSV----------FPPEPEEPEADQHQPFLFRHASYSSTTSDCETDGYLSSSGFLDASDPALQP 604
            ..|:          |||||||||||||.||.||...|||.|||||||||||||..::|.|...:|
 Frog   571 ATSLPLTSDSTERTFPPEPEEPEADQHHPFNFRPTCYSSATSDCETDGYLSSSSCMEAVDGQKKP 635

Human   605 PGGV--------PSSLAESHLCLPSAFALSI-----PRSGPGSDF-SPGDSYASDAASGLSDVGE 655
            ...|        ||:  |..:|.|.:.|:|:     |.....|:. ||.||||||.||||||..|
 Frog   636 SNDVSQEDSKSPPST--EPEICFPGSIAVSVNTEQLPFPVLSSEITSPVDSYASDVASGLSDGCE 698

Human   656 GMGQMRR---PPGRN-----LRRRPRSRLRVTSVSDQNDRVVECQLQTHNSKMVTFRFDLDGDSP 712
            |:....|   .|.:.     |||:.|||||:.::||:.||||||||||:|:|||||:||||||:|
 Frog   699 GLSAGERSIKSPAKKATTKLLRRKARSRLRIINISDKCDRVVECQLQTYNNKMVTFKFDLDGDNP 763

Human   713 EEIAAAMVYNEFILPSERDGFLRRIREIIQRVETLLKRDTGPMEAAEDTLSPQEE--PAPLPALP 775
            |:||..||.||||:.|||:.|..|||:||.|||||||:     ||..|.....||  .:|||
 Frog   764 EDIAVVMVNNEFIMLSERESFTNRIRDIIHRVETLLKK-----EANGDRDDEGEEFSNSPLP--- 820

Human   776 VPLPDPSNEELQSSTSLEHRSWTAFSTSS------SSP--GTPLSPGNPFSPGTPISPGPIFPIT 832
                    ..||:...|:..| .:||:||      .||  |.| |.|..|. .:|:....||...
 Frog   821 --------HNLQADLQLQELS-RSFSSSSLNDLVCPSPTKGVP-SQGYLFQ-SSPVLDSDIFGTA 874

Human   833 SP---------PCH-PSPSPFSPI-------SSQVSSNPS-------PHPTSSPLP--------- 864
            .|         ..| |:.|..||:       |.:.:|||:       ..|||...|
 Frog   875 GPLLTSADLGSKSHLPAMSTGSPMTASRTWPSFETASNPAGSFPSGYSMPTSQSFPPAIFSSMQS 939

Human   865 --FSSSTPEFPVPLSQCPWSSLPTTSPPTFSPTCS-------QVTLSSPFFPP-------CPSTS 913
              :.||.|:..:|.|    |:.|.:||.|..|...       |..|:|...||       ..::|
 Frog   940 GNYLSSLPQHMMPSS----SAGPISSPNTVFPNLMGSHQNSLQHMLNSGMVPPNINNAVSALASS 1000

Human   914 SFPST---TAAPLLSLASAFSLAVMTVAQSLL--------------------------------- 942
            :.|.|   ..||:.|||:..||| |::||:||
 Frog  1001 AQPVTQWSPTAPMFSLANVLSLA-MSMAQTLLPVASPSTAQPPGIPPGGPLFPQAISGAIQSPLM 1064

Human   943 --------------SP----------------SPGLLSQSPPA------------PPSPLPSLPL 965
                          ||                |.|||.|:.||            |..|..:||.
 Frog  1065 YPQSYSQPQSPVKESPTALGQCQYMYPAGPAHSSGLLLQNMPAQNFSNIGGTFLQPFVPQETLPQ 1129

Human   966 ---------------------------PPPVAPGGQESPSP---------------HTAE----- 983
                                       ||||.|..|....|               .|:|
 Frog  1130 SGVIASNLQSTSVPGFQLQHPQQIKEGPPPVVPPDQSRLPPVLGTFNEASSAPLGNKTSEATGSV 1194

Human   984 -----------VESEASPP----PARPLPGEARLAPISEEGKPQLVGRFQVTSSKEPAEPLPLQP 1033
                       :.||:.||    .::|||.    |.:....:|::|||||||:||:      ||.
 Frog  1195 VGQTMNKPVQSITSESGPPSPISTSKPLPS----AALGNGVQPKVVGRFQVTTSKD------LQE 1249

Human  1034 TSP--TLSGSPKPS----------TPQL-TSESSDTE---DSAGGG-----PE------------ 1065
            :||  :::.||:.|          ||.: .:.||||:   |:|..|     ||
 Frog  1250 SSPECSVNSSPETSKRSEARSSDTTPDVYETASSDTDISTDNATEGHDFSEPEIFSPCSVDTLNT 1314

Human  1066 --------------TREAL----AESDR------------------------------------- 1075
                          ::|.|    ::|||
 Frog  1315 YSYRHDTSSESEAFSQERLGAFRSDSDRLTLMSNITDTEDSCPCVLNNNTNPESDLGYQVNSGVQ 1379

Human  1076 -------------------AAEGLGAGVEEEGDDGKEPQVGGSPQPLSHPSPVWMNYSYSSLCLS 1121
                               |..|.|.|.:.....|:|.:  .:||.:| ...|:::|:...:.||
 Frog  1380 SHSKAGCIVNGDSTLDNKMAIVGDGQGSDSVSSSGEENE--KTPQHIS-TVQVYLHYTRGIVYLS 1441

Human  1122 SEESESSGEDEEFWAELQSLRQKHLSEVETLQTLQKKEIEDLYSRLGKQPPPGIVAPAAMLSSRQ 1186
            |:::||  ||||.:.|||.|||||:|||:.||.|||||||:||.|:||.||||||:||||||:||
 Frog  1442 SDDTES--EDEEIFEELQQLRQKHMSEVQLLQALQKKEIEELYYRMGKVPPPGIVSPAAMLSNRQ 1504

Human  1187 RRLSKGSFPTSRRNSLQRSE-PPGPGIMRRNSLSGSSTGSQEQRASKGVTFAGDVGRMVRAGPRE 1250
            ||||||||..||||||||.| .|..|.:|:|||.||||||||||.:|||||:||:.||...|...
 Frog  1505 RRLSKGSFNQSRRNSLQRLELMPATGFIRKNSLGGSSTGSQEQRLNKGVTFSGDMTRMATTGSSS 1569

Human  1251 GEPRE 1255
            .|..|
 Frog  1570 SETSE 1574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WNK4	XP_016880451.1	STKc_WNK4	172..432	CDD:270935	228/259 (88%)
		OSR1_C	453..515	CDD:463491	39/62 (63%)
		PHA03247	<798..1074	CDD:223021	120/523 (23%)
wnk4	XP_002932565.2	STKc_WNK4	175..435	CDD:270935	228/259 (88%)
		OSR1_C	456..518	CDD:463491	38/61 (62%)