DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SMTN and Ehbp1

DIOPT Version :9

Sequence 1:	NP_001369571.1	Gene:	SMTN / 6525	HGNCID:	11126	Length:	1009	Species:	Homo sapiens
Sequence 2:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster

Alignment Length:	490	Identity:	111/490 - (22%)
Similarity:	180/490 - (36%)	Gaps:	107/490 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   550 SMKTTFTIEIKDGRGQASTGRVLLPTGNQRAELTLGLRAPPTLL----STSSGGKSTITRV---- 606
            |.:.:||:.:|             |...:....:|.|......|    :|....:|.::.:
  Fly   129 STQQSFTLSLK-------------PVSKKITAASLELTISCVFLREGKATDEDMQSVVSMMSVNN 180

Human   607 NSPGTLARLGSVTHVTSFSHAP-------------PSSRGGC-------SIKMEAEPAEPLAAAV 651
            |....|..|..:..:..||...             .:|..||       |:...:|...|||.:.
  Fly   181 NDVAPLDDLEDIPDLDGFSEITDNFNDFTQQLEHMTTSLNGCIDVATPQSVPSLSEDPTPLAESF 245

Human   652 -------------EAANGAEQTRVNKAPEGRSPLSAEELMTIED-EGVLDKMLDQSTDFEERKLI 702
                         ||||..:   :..|..|.|..:.|.|.|... :.|:|:...:|.|
  Fly   246 NPLHFELDADGKREAANKLD---LPTAASGGSSGAEESLKTPNGLQHVVDQTPIKSPD------- 300

Human   703 RAALRELRQRKRDQRDKERERRLQEARGRPGEGRGNTATETTTRHSQRAADGSAVSTVTKTERLV 767
                 |::|.|:                          |...:..|:...|...:.|.|..|..|
  Fly   301 -----EVKQPKQ--------------------------TPVESLRSKTNEDFDKMVTSTPLEPNV 334

Human   768 HSND----GTRTARTTTVESSFVRRSENGSGSTMMQTKTFSSSSSSKKMGSIFDREDQASPRAGS 828
            :.:|    ..|....|..|.....|.|:....|   |||...:|::|:...   .|.|:|..|.|
  Fly   335 NKDDVKPKKKRALFFTEKEDEQDLRVESVKEDT---TKTIGDNSTTKEKPK---EESQSSKDASS 393

Human   829 LAALEKRQAEKKKELMKAQSLPKTSASQARKAMIEKLEKEGAAGSPGGPRAAVQRSTSFGVPNAN 893
            :.....::.|.:...:|....|..:...|........|..|:..|..|......:.....|...|
  Fly   394 VVVPSAKRPELQPLNLKKSYEPSQTPESAPVPASVINESIGSCFSTSGSLNNSLKPVEKIVLKEN 458

Human   894 SIKQMLLDWCRAKTRGYEHVDIQNFSSSWSDGMAFCALVHNFFPEAFDYGQLSPQNRRQNFEVAF 958
            :..|.||:||:..|:.|.:|.:.|.::||.:||||||::|:|.||..|..:||..:...|..:.|
  Fly   459 TPGQDLLEWCKEVTKDYPNVKVTNLTTSWRNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGF 523

Human   959 SSAETHADCPQLLDTEDMVRLREPDWKCVYTYIQE 993
            .:||: ...|::::..||..|..||...|.||:.:
  Fly   524 DAAES-LGIPRVIEPRDMNMLTVPDKLAVMTYLHQ 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMTN	NP_001369571.1	Smoothelin	86..128	CDD:403640
		Smoothelin	167..216	CDD:403640
		Smoothelin	664..713	CDD:403640	12/49 (24%)
		CH_SMTNB	894..1005	CDD:409108	37/100 (37%)
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345	8/48 (17%)
		CH	460..562	CDD:237981	37/99 (37%)
		DUF3585	<1027..1122	CDD:288945
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910