DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Xpo7 and Ranbp16

DIOPT Version :9

Sequence 1:	XP_006519422.1	Gene:	Xpo7 / 65246	MGIID:	1929705	Length:	1097	Species:	Mus musculus
Sequence 2:	NP_001188596.1	Gene:	Ranbp16 / 118436	FlyBaseID:	FBgn0053180	Length:	1110	Species:	Drosophila melanogaster

Alignment Length:	1091	Identity:	636/1091 - (58%)
Similarity:	822/1091 - (75%)	Gaps:	22/1091 - (2%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 LAQLENLCKQLYETTDTTTRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQLLAATCLTKLVS 73
            :.|||.|||||||.||...|.:||||||.|.:|.|.|.||||||:|..|||:|||||:.||||:
  Fly     3 IQQLEVLCKQLYEATDIRIRSEAEKALVTFVSSQDALPKCQLLLQRADSSYAQLLAASTLTKLI- 66

Mouse    74 RTNNPLPLEQRIDIRNYVLNYLATRPKLATFVTQALIQLYARITKLGWFDCQKDDYVFRNAITDV 138
               ..|.|::|||||:|.||||||.|.|..||.|||:.|.|::||.||||..|::.||:|.:.||
  Fly    67 ---QGLSLQERIDIRSYALNYLATVPNLQHFVVQALVSLLAKLTKYGWFDSYKEEMVFQNLLEDV 128

Mouse   139 TRFLQDSVEYCIIGVTILSQLTNEINQVSATAFLIEADTTHPLTKHRKIASSFRDSSLFDIFTLS 203
            .:|||.|||:|.|||.|||||..|:|.|      :|.|.....:|.||||:||||..|.:.|.||
  Fly   129 KKFLQGSVEHCTIGVQILSQLVCEMNSV------VEMDVQVSFSKMRKIATSFRDQQLLETFLLS 187

Mouse   204 CNLLKQA--SGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESSDDLCTVQIPTSWRSAF 266
            |:||..|  :.||::..||||..|:..:|:||.|||:|||||:|||||:||:..|||||:||.||
  Fly   188 CSLLVSARDNSKNISFMDESQQALISHVLRLTKNCLSFDFIGSSTDESADDMNNVQIPTAWRPAF 252

Mouse   267 LDSSTLQLFFDLYHSIPPSFSPLVLSCLVQIASVRRSLFNNAERAKFLSHLVDGVKRILENPQSL 331
            |||:||:||||||..:|...:...:||||||.|||||||||:||.|||:|||:|||.||.....|
  Fly   253 LDSNTLKLFFDLYQILPNGLASYSISCLVQITSVRRSLFNNSERTKFLTHLVEGVKDILTTLHGL 317

Mouse   332 SDPNNYHEFCRLLARLKSNYQLGELVKVENYPDVIRLIANFTVTSLQHWEFAPNSVHYLLSLWQR 396
            |||:|||||||||||||||||||||:.|..||:.|:|||.|||.||..|.||||||||||:||||
  Fly   318 SDPDNYHEFCRLLARLKSNYQLGELIAVPCYPEAIQLIAKFTVESLHLWLFAPNSVHYLLTLWQR 382

Mouse   397 LAASVPYVKATEPHMLETYTPEVTKAYITSRLESVHIILRDGLEDPLEDTGLVQQQLDQLSTIGR 461
            :.|||||||:.:||:|.||||||.||||.|||::|.:|:||.|:|||:|..:|||||:|||.|.|
  Fly   383 MVASVPYVKSPDPHLLGTYTPEVIKAYIESRLDAVPVIIRDNLDDPLDDFCMVQQQLEQLSVIER 447

Mouse   462 CEYEKTCALLVQLFDQSAQSYQELLQSASASPMDIAVQEGRLTWLVYIIGAVIGGRVSFASTDEQ 526
            |||.|||.||||.|||.|:.|:.|||:.:|:.:||.:.|.:|||||||||:.|.||::.|::||.
  Fly   448 CEYNKTCNLLVQHFDQKAREYENLLQTPNANSIDITIHELQLTWLVYIIGSAIVGRLTVATSDEH 512

Mouse   527 DAMDGELVCRVLQLMNLTDSRLAQAGNEKLELAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLG 591
            |.||.|||.||||||.|||:||.|||.||||||:|||.:|.||::..:|.||:: |.:|||||.|
  Fly   513 DTMDAELVIRVLQLMTLTDARLPQAGCEKLELAILSFLDQVRKMHSSEQAQKAN-LNKRLSEVFG 576

Mouse   592 LNDETMVLSVFIGKVITNLKYWGRCEPITSKTLQLLNDLSIGYSSVRKLVKLSAVQFMLNNHTSE 656
            |.||.|:||....|:|||||:|||.|.|.:|||.||::||:.::|||||.:|..|||||.:||||
  Fly   577 LTDEQMLLSFINRKIITNLKFWGRSESIITKTLMLLSELSVHFNSVRKLARLEEVQFMLTHHTSE 641

Mouse   657 HFSFLGINNQSNLTDMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFEAVAQ-MFSTNSF 720
            ||.|||.|  |:|::|||||.|||:||||||.||||||:::..|:.|||..||::.. |...|.|
  Fly   642 HFPFLGTN--SSLSEMRCRTMFYTSLGRLLMFDLGEDEERFYNFLEPLTNQFESLGSVMMDNNIF 704

Mouse   721 NEQEAKRTLVGLVRDLRGIAFAFNAKTSFMMLFEWI-YPSYMPILQRAIELWYHDPACTTPVLKL 784
            :.:|||:.::||.|||||:|...||:..:.|||||: |..|:|||.||::||.||||.|||:|||
  Fly   705 SNEEAKKVIIGLARDLRGLALPLNARIQYTMLFEWLYYADYLPILLRAMDLWAHDPAVTTPILKL 769

Mouse   785 MAELVHNRSQRLQFDVSSPNGILLFRETSKMITMYGNRILTLGEVPKDQVYALKLKGISICFSML 849
            .|||||.|:|||..:||||.|||||||.||:|.:||||||. .|||::::|.::||||:|||.:|
  Fly   770 FAELVHCRTQRLAGNVSSPMGILLFREASKLICIYGNRILH-QEVPRERLYPMRLKGIAICFLIL 833

Mouse   850 KAALSGSYVNFGVFRLYGDDALENALQTFIKLLLSIPHSDLLDYPKLSQSYYSLLEVLTQDHMNF 914
            |.:|.|:|||.|||:|||||.|::.|....||:|:|...||::|||||.:||:||..|:|||:::
  Fly   834 KNSLGGNYVNCGVFKLYGDDTLDSVLNIIAKLILTIEQRDLIEYPKLSTAYYNLLNCLSQDHVSY 898

Mouse   915 IASLEPHVIMYILSSISEGLTALDTMVCTGCCSCLDHIVTYLFKQL----SRSTKKRTTPLNRES 975
            :|:|||...:|||.|:::||.|||:.....||:.||.||:|:||||    |....|:...||:|:
  Fly   899 LAALEPAAFVYILKSLTKGLAALDSATYISCCTILDSIVSYIFKQLQMKVSTFPNKKLRSLNQEN 963

Mouse   976 DCFLHIMQQHPAMIQQMLSTVLNIIIFEDCRNQWSMSRPLLGLILLNEKYFSDLRNSIVNSQPPE 1040
            ..||.:::.:..::|.|:|::||.::.||||||||||||||.||||.|.|:..|::.|:.:||.|
  Fly   964 VQFLKVVEMNSELLQSMMSSLLNNVLQEDCRNQWSMSRPLLVLILLYEDYYRSLKDRIICAQPIE 1028

Mouse  1041 KQQAMHLCFENLMEGIERNLLTKNRDRFTQNLSAFRREVNDSMKNSTYGVN 1091
            |||.|...|::||.|||||:.:||:::||||:|.|||:|.:..|::..|.:
  Fly  1029 KQQTMAQWFDDLMVGIERNVSSKNKEKFTQNMSTFRRDVVNLPKSTAGGAD 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xpo7	XP_006519422.1	CRM1	30..>315	CDD:227432	166/286 (58%)
Xpo7	XP_006519422.1	IBN_N	31..97	CDD:197981	41/65 (63%)
Ranbp16	NP_001188596.1	IBN_N	25..87	CDD:281761	41/65 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849396
Domainoid	1	1.000	1121	1.000	Domainoid score	I19
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22857
Inparanoid	1	1.050	1231	1.000	Inparanoid score	I186
Isobase	1	0.950	-	0	Normalized mean entropy	S2669
OMA	1	1.010	-	-		QHG53933
OrthoDB	1	1.010	-	-		D198413at2759
OrthoFinder	1	1.000	-	-		FOG0004030
OrthoInspector	1	1.000	-	-		otm43287
orthoMCL	1	0.900	-	-		OOG6_102412
Panther	1	1.100	-	-	LDO	PTHR12596
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3705
SonicParanoid	1	1.000	-	-		X2778
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890