Protein Alignment SLC5A2 and bumpel

DIOPT Version :10

• Sequence 1: XP_006721135.3
• Gene: SLC5A2 / 6524
• HGNCID: 11037
• Length: 698
• Species: Homo sapiens
• Sequence 2: NP_650069.2
• Gene: bumpel / 41368
• FlyBaseID: FBgn0037895
• Length: 587
• Species: Drosophila melanogaster
• Alignment Length: 509
• Identity: 118/509 - (23%)
• Similarity: 212/509 - (41%)
• Gaps: 77/509 - (15%)

Human    25 DILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGA 89
            |.:...:.|||.||:|::........:...|.|.||.|:..|:..||.||.:.....:||.....
  Fly    18 DYVAFVSMFLLCIGIGIYFGFMNKSVSEDDYMLGGRKMLVIPIAFSLVASFVSGITLLGLPTEVY 82

Human    90 ASGLAVAGFEWNALFVVLLLGWLFAPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTK 154
            :.|:.........:.:.:::|..:.||:....:.:..:||..|| .||:|||.||:...:.: ..
  Fly    83 SYGIQYLYVSCGVIGMGVVMGVFYLPVFHDLNITSTYEYLEVRF-DRRLRLYGSVMFAIMNV-AY 145

Human   155 ISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYA 219
            :.:.::..|:...|..|..::.....:..|.:.||..|||.|:::||.||...:||..|::....
  Fly   146 LPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISMLGALCLVAIKG 210

Human   220 FHEVGGYSGLFDKYLGA----ATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALL 280
            ..::||...:.::...:    |..|::  ||.|                  ||..     |....
  Fly   211 TRDIGGAGVVLERAWSSDRLEAPDLSI--DPTV------------------RHTF-----WCLFF 250

Human   281 LGLTIVSGWYWCS----DQVIVQRCLAGKSLTHI-KAGCILCGYLKLTPMFLMVMPGMISRILYP 340
            .|:.     ||..    .|.::||.|:..||... ||.||.|    :..:.||.:.|....::|
  Fly   251 GGIV-----YWTQTNAVSQNMIQRYLSLPSLGDARKALCIFC----VGVLILMALCGYNGLLIY- 305

Human   341 DEVACVVPEVCRRVCGTEVGCSNIA----------YPRLVVKLMPN--GLRGLMLAVMLAALMSS 393
                           .|...|..:.          .|..|:|.:..  |:.||.:|.:.:|.:||
  Fly   306 ---------------ATYQNCDPLTTKLAKARDQLLPLFVMKTLGELPGMTGLFIAGVFSAALSS 355

Human   394 LASIFNSSSTLFTMD-IYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQ 457
            |::..||.|.:...| :...::.......:..:.||.||.:.|:.|..:.||:  ..|.:.....
  Fly   356 LSTCLNSMSAVVLEDFVKPYVKKPLSSSAINWIMRLVVVGVGVLCVCLVYVVE--HMGTVLQLTM 418

Human   458 AVSSYLAPPVSAVFVLALFVPRVNEQGAF-WGLIGGLLMGLARLIPEFSFGSGS 510
            ::.:....|:..:|.:.||:|.:|...|. .|::|.:.|....|..:::..||:
  Fly   419 SLEAITNGPLFGIFTIGLFLPWINGNSALVGGVMGVIAMSWVSLNAQWAIASGA 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A2	XP_006721135.3	SLC5sbd_SGLT2	24..698	CDD:212056	118/509 (23%)
bumpel	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	118/509 (23%)