Protein Alignment SLC5A2 and CG31668

DIOPT Version :9

• Sequence 1: XP_006721135.2
• Gene: SLC5A2 / 6524
• HGNCID: 11037
• Length: 705
• Species: Homo sapiens
• Sequence 2: NP_001097055.2
• Gene: CG31668 / 33395
• FlyBaseID: FBgn0051668
• Length: 590
• Species: Drosophila melanogaster
• Alignment Length: 641
• Identity: 142/641 - (22%)
• Similarity: 244/641 - (38%)
• Gaps: 142/641 - (22%)

Human    32 DILVIAAYFLLVIGVGLW-SMCRTNRG----------------------TVGGYFLAGRSMVWWP 73
            |..|.....:|.|.:||: ...|.:|.                      .:..|.:..|::..:|
  Fly    10 DYAVFLGVTILSIAIGLYFGFIRKSRNGPKTTTPTNEAPERRHQNFGSKKMNDYMMGSRNLRVFP 74

Human    74 VGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLL-----GWLFAPVYLTAGVITMP 133
            ||.||.||.|.:   |.:.||  .|.:...|.::..:.:.|:|     .:::.||:....|.:..
  Fly    75 VGMSLIASCISA---VAIIGT--PSEIYNYGTQYCFIVIALVLQGLAVSYIYLPVFSALQVTSSY 134

Human   134 QYLRKRFGG--RRIRLYLSVLSLFLYI-FTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIY 195
            :||..||..  |.|...:.:|.:.||: |.     .:..|:.:.|..|.|:|.....::.|.:||
  Fly   135 EYLEMRFHSAIRSIVSIIFILDVVLYLPFL-----AYLPALALNQVSGMNMYLIEAFIIVICVIY 194

Human   196 TVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISS 260
            ||.|||.|:::||..|..::......::..|...:...:. |.:.|.....|..||.
  Fly   195 TVLGGLKAVVHTDIWQVVIMFASVLTIVVLATCYIDDQAD-FLEGLVRGGRLIFSET-------- 250

Human   261 FCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCS----DQVIVQRCLAGKSLTHIKAGC 321
               .|.|    ..||.|     | ::::|.|    :||.|    .|.:|.|.:   ||..:|...
  Fly   251 ---NPSP----FARHTV-----W-SVVIGNT----FYWTSLNAVHQTVVHRYM---SLPTLKMAR 295

Human   322 ILCGYLKLTPMF---LMVMPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPN 383
            ....:|.:...|   |:...|::....|.|         |..:....:...:...|..||..:.:
  Fly   296 ASIAFLVVGAAFFISLLCYLGLLIFHAYRD---------CDPLSAGLIMNDDQLVPLFVVNSLGH 351

Human   384 --GLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTR-LRPRAGDRELLLVGRLWVVFIVVVSV 445
              |:.||.:|.:..|.:|||:...||:|.:...|:... .:...|:....:|.:..:|.:.:::.
  Fly   352 VYGMPGLFIAGIFGASLSSLSVYLNSTSLVILQDLVRGCFKMELGEWASTIVVKGSIVVLGLLAF 416

Human   446 AWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQG-AFWGLIGGLLMGLARLIP 509
            |.:.|::...|  :.....::::..|.....:|.:.:.||..|..| |..|:...||.|......
  Fly   417 AMVFVLEKVSG--VLSISVSLAAIAASSTFGIFTVGMLVPWANTVGTAVGGIASVLLTGWISFGS 479

Human   510 EFSFGSGSC------VQPSAC------------------PAFLCGVHYLYFAIVLFFCSGLLTLT 550
            :|:..||..      |....|                  |.:....|::       ...|:||:.
  Fly   480 QFAAASGQLGSQRLPVSVEGCLANASVAENAWVAEEEVFPLYRLSYHWI-------SPIGVLTVV 537

Human   551 -----VSLCTAPIPRKHL---------HRLVFSLRHSKEEREDLDADEQQGSSLPV 592
                 |||.|.|...|.|         ||.:     .||..|..:|:|......|:
  Fly   538 VVGSLVSLVTKPTDIKSLDSDLITPVIHRFL-----PKECFEQGNAEENSVKDNPL 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A2	XP_006721135.2	SLC5sbd_SGLT2	31..705	CDD:212056	142/641 (22%)
CG31668	NP_001097055.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	124/577 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146439
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750