Protein Alignment SLC5A2 and CG33124

DIOPT Version :9

• Sequence 1: XP_006721135.2
• Gene: SLC5A2 / 6524
• HGNCID: 11037
• Length: 705
• Species: Homo sapiens
• Sequence 2: NP_001097056.3
• Gene: CG33124 / 318891
• FlyBaseID: FBgn0053124
• Length: 588
• Species: Drosophila melanogaster
• Alignment Length: 626
• Identity: 137/626 - (21%)
• Similarity: 249/626 - (39%)
• Gaps: 128/626 - (20%)

Human    32 DILVIAAYFLLVIGVGLW-------------------SMCRTNRGT--VGGYFLAGRSMVWWPVG 75
            |..|.....:|.|.:||:                   .:...|.|:  :..|.:....:..:||.
  Fly    10 DYTVFLGVTILSIAIGLYFGWIKKTKKEMESSPADTPEISIPNFGSKKMNEYLMGSGHLKVFPVA 74

Human    76 ASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLL-----GWLFAPVYLTAGVITMPQY 135
            .||.||.|.     |:|..|..|.:...|.:::.:.:.:::     .:::.||:....|.:..:|
  Fly    75 MSLIASFIS-----GVAILGNPSEIYYYGTQYSLIVLAIVIQGLAVSYIYLPVFSALQVRSSYEY 134

Human   136 LRKRFGG--RRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVT 198
            |..||..  |.|...:.|:.:.||  |...|  |..|:.:.||.|.||:...:.::.:.:|||:.
  Fly   135 LGMRFHPLIRNIVSIMFVIEVLLY--TPFVV--FVPALALNQASGLNIHMIEVLIIVVCVIYTLL 195

Human   199 GGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCY 263
            |||.|:::||..|..::.....::...|...:......|:..:.....:       .|||:
  Fly   196 GGLKAVVHTDIWQVVIMFASVVVVAILATCYITDLDDFFESLVDGGRLI-------FGNIN---- 249

Human   264 RPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCS----DQVIVQRCLAGKSLTHIKAGCILC 324
               |..|  :|:.|     |..::.|     .:||.|    .|.:|.|.:   ||.::|......
  Fly   250 ---PSPY--VRNTV-----WSVVIGG-----AFYWTSITAVHQTMVHRYM---SLPNLKMARTSI 296

Human   325 GYLKL-TPMFLMVMP--GMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPN--G 384
            .:..| :.:|..|:.  |::...:|.|         |..:...::..::...|..||:.:.:  |
  Fly   297 AFFVLGSIIFYSVLSFLGLLIFNMYKD---------CDPLSAGQIMNNDQLVPLFVVQSVGHIYG 352

Human   385 LRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYT---RLRPRAGDRELLLVGRLWVVFIVVVSVA 446
            :.||.:|.:..|.:|||:...||:|.:...||..   :::|  |:....::.:..:|.:..:...
  Fly   353 IPGLFIAGIFGAGLSSLSVFLNSTSLVILQDIVRGCFKMQP--GETASAIIVKATIVIMGALVFG 415

Human   447 WLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQG-AFWGLIGGLLMGLARLIPE 510
            .:.:::...|  :.....::.:........:|.||:.||..|..| |..|:.|.||.|......:
  Fly   416 EVLLLEKVSG--ILSICMSLVAIATSSTFGIFTLAVLVPWANTVGTAVGGIAGFLLTGWITFGSQ 478

Human   511 FSFGSGSC------VQPSACPAFLCGVHYLYF----AIVLFFCS-------GLLTLT-----VSL 553
            .:..||..      |..::||..:.....::.    ...||..|       |.||:.     |||
  Fly   479 IAAASGQLHHHRLPVSVASCPGNVTARENVWVDEEQVFPLFRLSFHWINPIGALTVVVVGSLVSL 543

Human   554 CTAPIPRKHL---------HRLV----FSLRH-SKEEREDL 580
            .|.|...|.|         ||.:    |..|: .|.|..|:
  Fly   544 VTKPTDIKSLDSDLISPVIHRFLPKECFKQRNLDKSEATDI 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A2	XP_006721135.2	SLC5sbd_SGLT2	31..705	CDD:212056	137/626 (22%)
CG33124	NP_001097056.3	SLC5sbd_NIS-SMVT	9..533	CDD:271383	121/573 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146438
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750