Protein Alignment SLC5A1 and CG31668

DIOPT Version :9

• Sequence 1: NP_000334.1
• Gene: SLC5A1 / 6523
• HGNCID: 11036
• Length: 664
• Species: Homo sapiens
• Sequence 2: NP_001097055.2
• Gene: CG31668 / 33395
• FlyBaseID: FBgn0051668
• Length: 590
• Species: Drosophila melanogaster
• Alignment Length: 647
• Identity: 142/647 - (21%)
• Similarity: 249/647 - (38%)
• Gaps: 159/647 - (24%)

Human    28 DISIIVIYFVVVMAVGLWAMF------------STNRG-----------TVGGFFLAGRSMVWWP 69
            |.::.:...::.:|:||:..|            .||..           .:..:.:..|::..:|
  Fly    10 DYAVFLGVTILSIAIGLYFGFIRKSRNGPKTTTPTNEAPERRHQNFGSKKMNDYMMGSRNLRVFP 74

Human    70 IGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVL-----GWLFVPIYIKAGVVTMP 129
            :|.||.||.|.:   |.:.||  .|.|...|.::..:|:.:||     .::::|::....|.:..
  Fly    75 VGMSLIASCISA---VAIIGT--PSEIYNYGTQYCFIVIALVLQGLAVSYIYLPVFSALQVTSSY 134

Human   130 EYLRKRFGG--QRIQVYLSLLSLLLYI-FTKISADIFSGAIFINLALGLNLYLAIFLLLAITALY 191
            |||..||..  :.|...:.:|.::||: |.     .:..|:.:|...|:|:||....::.|..:|
  Fly   135 EYLEMRFHSAIRSIVSIIFILDVVLYLPFL-----AYLPALALNQVSGMNMYLIEAFIIVICVIY 194

Human   192 TITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCY 256
            |:.|||.||::||..|.|||....|.:...|...:.....|:|       .:|..|...|.|...
  Fly   195 TVLGGLKAVVHTDIWQVVIMFASVLTIVVLATCYIDDQADFLE-------GLVRGGRLIFSETNP 252

Human   257 TPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYW----CTDQVIVQRCLSAKNMSHVKGGCILC 317
            :|.|.  |.              ::.:.|...:||    ...|.:|.|.:|...:...:...
  Fly   253 SPFAR--HT--------------VWSVVIGNTFYWTSLNAVHQTVVHRYMSLPTLKMARASI--- 298

Human   318 GYLKLMPMFIMVMPG-MISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPN--GLR 379
                   .|::|... .||.:.|...:......:|:......:...:...|..||..:.:  |:.
  Fly   299 -------AFLVVGAAFFISLLCYLGLLIFHAYRDCDPLSAGLIMNDDQLVPLFVVNSLGHVYGMP 356

Human   380 GLMLSVMLASLMSSLTSIFNSASTLFTMDIYA---KVRKRASEKELMIAGRLFILVLIGISIAWV 441
            ||.::.:..:.:|||:...||.|.:...|:..   |:........:::.|.:.:|.|:..::.:
  Fly   357 GLFIAGIFGASLSSLSVYLNSTSLVILQDLVRGCFKMELGEWASTIVVKGSIVVLGLLAFAMVF- 420

Human   442 PIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIF-------WKRVNEPG-AFWGLILGLLIGIS 498
              |....||.|     ||:..|. .|||.....||       |  .|..| |..|:...||.|..
  Fly   421 --VLEKVSGVL-----SISVSLA-AIAASSTFGIFTVGMLVPW--ANTVGTAVGGIASVLLTGWI 475

Human   499 RMITEFAYGTG------------SCM------------EPSNCPTIICGVHYLYFAIILFAISFI 539
            ...::||..:|            .|:            |....|......|:      :..|..:
  Fly   476 SFGSQFAAASGQLGSQRLPVSVEGCLANASVAENAWVAEEEVFPLYRLSYHW------ISPIGVL 534

Human   540 TIVV----ISLLTKP-----------IPDVH--LYRLCWSLRNSKEERIDLDAEEENIQEGP 584
            |:||    :||:|||           .|.:|  |.:.|:...|         |||.::::.|
  Fly   535 TVVVVGSLVSLVTKPTDIKSLDSDLITPVIHRFLPKECFEQGN---------AEENSVKDNP 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A1	NP_000334.1	SLC5sbd_SGLT1	27..664	CDD:271379	142/647 (22%)
CG31668	NP_001097055.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	124/580 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146459
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750