Protein Alignment SLC5A1 and CG33124

DIOPT Version :10

• Sequence 1: NP_000334.1
• Gene: SLC5A1 / 6523
• HGNCID: 11036
• Length: 664
• Species: Homo sapiens
• Sequence 2: NP_001097056.3
• Gene: CG33124 / 318891
• FlyBaseID: FBgn0053124
• Length: 588
• Species: Drosophila melanogaster
• Alignment Length: 629
• Identity: 138/629 - (21%)
• Similarity: 250/629 - (39%)
• Gaps: 137/629 - (21%)

Human    28 DISIIVIYFVVVMAVGLW---------AMFSTNRGT------------VGGFFLAGRSMVWWPIG 71
            |.::.:...::.:|:||:         .|.|:...|            :..:.:....:..:|:.
  Fly    10 DYTVFLGVTILSIAIGLYFGWIKKTKKEMESSPADTPEISIPNFGSKKMNEYLMGSGHLKVFPVA 74

Human    72 ASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVL-----GWLFVPIYIKAGVVTMPEY 131
            .||.||.|.     |:|..|..|.|...|.:::.:||.:|:     .::::|::....|.:..||
  Fly    75 MSLIASFIS-----GVAILGNPSEIYYYGTQYSLIVLAIVIQGLAVSYIYLPVFSALQVRSSYEY 134

Human   132 LRKRFGG--QRIQVYLSLLSLLLYI-FTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTI 193
            |..||..  :.|...:.::.:|||. |.     :|..|:.:|.|.|||:::...|::.:..:||:
  Fly   135 LGMRFHPLIRNIVSIMFVIEVLLYTPFV-----VFVPALALNQASGLNIHMIEVLIIVVCVIYTL 194

Human   194 TGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTP 258
            .|||.||::||..|.|||....:::...|...:...|.|.|       ::|..|...|.
  Fly   195 LGGLKAVVHTDIWQVVIMFASVVVVAILATCYITDLDDFFE-------SLVDGGRLIFG------ 246

Human   259 RADSFHIFRDPLTGDLPWPGFIFGMSILTLWYW----CTDQVIVQRCLSAKNMS--------HVK 311
                 :|...|...:..|...|.|     .:||    ...|.:|.|.:|..|:.        .|.
  Fly   247 -----NINPSPYVRNTVWSVVIGG-----AFYWTSITAVHQTMVHRYMSLPNLKMARTSIAFFVL 301

Human   312 GGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPN 376
            |..|....|..:.:.|..|        |         .:|:.....::...:...|..||:.:.:
  Fly   302 GSIIFYSVLSFLGLLIFNM--------Y---------KDCDPLSAGQIMNNDQLVPLFVVQSVGH 349

Human   377 --GLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYA---KVRKRASEKELMIAGRLFILVLIGI 436
              |:.||.::.:..:.:|||:...||.|.:...||..   |::...:...:::..   .:|::|.
  Fly   350 IYGIPGLFIAGIFGAGLSSLSVFLNSTSLVILQDIVRGCFKMQPGETASAIIVKA---TIVIMGA 411

Human   437 SIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILG-LLIGISRM 500
            .:....::....|| :.....|:.:........:|.||:.....|..|...|.|.| ||.|....
  Fly   412 LVFGEVLLLEKVSG-ILSICMSLVAIATSSTFGIFTLAVLVPWANTVGTAVGGIAGFLLTGWITF 475

Human   501 ITEFAYGTGSC------MEPSNCPTIICGVHYLYF----AIILFAISF--------ITIVV---- 543
            .::.|..:|..      :..::||..:.....::.    ...||.:||        :|:||
  Fly   476 GSQIAAASGQLHHHRLPVSVASCPGNVTARENVWVDEEQVFPLFRLSFHWINPIGALTVVVVGSL 540

Human   544 ISLLTKPI-----------PDVH--LYRLCWSLRN-SKEERIDL 573
            :||:|||.           |.:|  |.:.|:..|| .|.|..|:
  Fly   541 VSLVTKPTDIKSLDSDLISPVIHRFLPKECFKQRNLDKSEATDI 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A1	NP_000334.1	SLC5sbd_SGLT1	27..664	CDD:271379	138/629 (22%)
CG33124	NP_001097056.3	SLC5sbd_NIS-SMVT	9..533	CDD:271383	121/576 (21%)