Protein Alignment SLC4A2 and Ndae1

DIOPT Version :10

• Sequence 1: NP_003031.3
• Gene: SLC4A2 / 6522
• HGNCID: 11028
• Length: 1241
• Species: Homo sapiens
• Sequence 2: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Alignment Length: 1056
• Identity: 395/1056 - (37%)
• Similarity: 587/1056 - (55%)
• Gaps: 94/1056 - (8%)

Human   241 IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFE------DVPGVRRHLVRK-------- 291
            :.|.:|.::|  |:.|....|..|....:.| .:.||..      .|||.|||..|:
  Fly    14 MNSSSGDDEA--PKDPRTGGEDFTQQFTEND-FEGHRAHTVYVGVHVPGGRRHSQRRRKHHHSGP 75

Human   292 -------------NAKGSTQSG----------REGREPGPTPRARPR---------APHKPHEVF 324
                         ...||...|          :|...|...|..|.:         ..|..|.:|
  Fly    76 GGGGGGGGGGGSIGGSGSVGGGAGKDNVSEKQQEVERPVTPPAQRVQFILGEDVDDGTHVSHPLF 140

Human   325 VELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDL 389
            .|:. :|:.:..|.:|:||||||||||||||...||.|||||:||..||.||||.|.:|:|:||:
  Fly   141 SEMG-MLVKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDM 204

Human   390 DQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSD-EKDFSFPRNISAGSLGSLLGH 453
            :.|.|..:|..|.:.||.:..:....:..|..|||.:|.|..: .|....|   ...||..:..|
  Fly   205 EAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLP---IIRSLADMRNH 266

Human   454 HHGQGAESDPHVTEPL--MGGVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEKIPENAEA 516
            ...:..:|:...:.|.  :..:.|..::....:.:..|.....::..:.|.....:.|||..|||
  Fly   267 SSSKKKKSNSKHSRPAQNLSSITEDMVKSPSNQSMARPGSGTELSEQQHKGNTHFMRKIPPGAEA 331

Human   517 TVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMS 581
            :.:|||.|:||.|....|:||.:||.|..:.|||||.||:|:||||..:..::|||||:::||||
  Fly   332 SNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAMATLMS 396

Human   582 DKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPT 646
            |:.|||.||.|.:|:.||:.::.|||...||||.|......:...|....|.::||..:
  Fly   397 DEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEVRKRPPE------ 455

Human   647 GAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAA 711
                .||...|    :..|.|...|::.|.||||.|||||.|::|:.|.|:||::|||..||:|:
  Fly   456 ----LPKEEVD----EEEEEARLREENGLSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVAS 512

Human   712 VIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEE 776
            .||:|||.|||.|||||||.|.|...:...|.::|..:.|:.:.....|||.::|.:||:||||.
  Fly   513 WIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFES 577

Human   777 AFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFY 841
            ..:.||.....:|:..|.|||.|:..:.:::.|::.|.||.:::|||:|.||.||:.||||:...
  Fly   578 IIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIE 642

Human   842 KLVKIFQEHP----LHGC-----SASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQ 897
            .::.|.:..|    ::.|     ..||:|.:|..: ..|......    |.:|.| ...|.|..:
  Fly   643 NVMVIGKNFPVNQGIYDCVCTPPIGSNASVIDYAK-YNWDSCESY----NGTLVG-GDCGTPPTE 701

Human   898 PNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKL 962
             |..|:|:||.||||.|:..|::|||:.|||..:|:.|.||.|.|||..|...|||: ...||||
  Fly   702 -NVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSL-GVPTQKL 764

Human   963 SVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQ 1027
            .||:....|. ..|||:|.|..||:|:  |..:.::.||:|..|||||:.|||.:|:::||..|:
  Fly   765 EVPNELKPTL-STRGWLIPPFVEKNPW--WSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLK 826

Human  1028 KGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVT 1092
            ||.|:||||.::..:..||::.||||..||||.|:.|.|:|.:.|:..|||:||:...|:|||||
  Fly   827 KGCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVT 891

Human  1093 GLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKK 1157
            .:|:.|.:|:|:::..||..||:.||||:||||||.||.|:||::|:.::.||.|:.||..::::
  Fly   892 HILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQ 956

Human  1158 VRTLRMHLFTALQLLCLALLWAVMS-TAASLAFPFILILTVPLRMVVLTRIFTDREMKCLDANEA 1221
            |...|:||||.:||.||.:||.:.| :..|:.||.:|::.:.:|. .|..:||.||:|.||  :.
  Fly   957 VPIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRK-ALDLVFTRRELKILD--DI 1018

Human  1222 EPVFDEREGVDEYNEM 1237
            .|...:|...|:.:::
  Fly  1019 MPEMTKRAAADDLHKL 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC4A2	NP_003031.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..240
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	288..320		9/71 (13%)
		ae	324..1240	CDD:273290	369/927 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..471		3/23 (13%)
		Membrane (anion exchange)	708..1241		220/540 (41%)
Ndae1	NP_723263.2	Band_3_cyto	140..1016	CDD:452680	364/905 (40%)