DRSC/TRiP Functional Genomics Resources

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Protein Alignment SLC4A2 and Ndae1

DIOPT Version :9

Sequence 1:NP_001186621.1 Gene:SLC4A2 / 6522 HGNCID:11028 Length:1241 Species:Homo sapiens
Sequence 2:NP_723263.2 Gene:Ndae1 / 34005 FlyBaseID:FBgn0259111 Length:1190 Species:Drosophila melanogaster


Alignment Length:1056 Identity:395/1056 - (37%)
Similarity:587/1056 - (55%) Gaps:94/1056 - (8%)


- Green bases have known domain annotations that are detailed below.


Human   241 IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFE------DVPGVRRHLVRK-------- 291
            :.|.:|.::|  |:.|....|..|....:.| .:.||..      .|||.|||..|:        
  Fly    14 MNSSSGDDEA--PKDPRTGGEDFTQQFTEND-FEGHRAHTVYVGVHVPGGRRHSQRRRKHHHSGP 75

Human   292 -------------NAKGSTQSG----------REGREPGPTPRARPR---------APHKPHEVF 324
                         ...||...|          :|...|...|..|.:         ..|..|.:|
  Fly    76 GGGGGGGGGGGSIGGSGSVGGGAGKDNVSEKQQEVERPVTPPAQRVQFILGEDVDDGTHVSHPLF 140

Human   325 VELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDL 389
            .|:. :|:.:..|.:|:||||||||||||||...||.|||||:||..||.||||.|.:|:|:||:
  Fly   141 SEMG-MLVKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDM 204

Human   390 DQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSD-EKDFSFPRNISAGSLGSLLGH 453
            :.|.|..:|..|.:.||.:..:....:..|..|||.:|.|..: .|....|   ...||..:..|
  Fly   205 EAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLP---IIRSLADMRNH 266

Human   454 HHGQGAESDPHVTEPL--MGGVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEKIPENAEA 516
            ...:..:|:...:.|.  :..:.|..::....:.:..|.....::..:.|.....:.|||..|||
  Fly   267 SSSKKKKSNSKHSRPAQNLSSITEDMVKSPSNQSMARPGSGTELSEQQHKGNTHFMRKIPPGAEA 331

Human   517 TVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMS 581
            :.:|||.|:||.|....|:||.:||.|..:.|||||.||:|:||||..:..::|||||:::||||
  Fly   332 SNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNFHEIGRAMATLMS 396

Human   582 DKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPT 646
            |:.|||.||.|.:|:.||:.::.|||...||||.|......:...|....|.::||..:      
  Fly   397 DEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEVRKRPPE------ 455

Human   647 GAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAA 711
                .||...|    :..|.|...|::.|.||||.|||||.|::|:.|.|:||::|||..||:|:
  Fly   456 ----LPKEEVD----EEEEEARLREENGLSRTGRLFGGLINDIKRKAPWYISDYKDALSMQCVAS 512

Human   712 VIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEE 776
            .||:|||.|||.|||||||.|.|...:...|.::|..:.|:.:.....|||.::|.:||:||||.
  Fly   513 WIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFES 577

Human   777 AFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFY 841
            ..:.||.....:|:..|.|||.|:..:.:::.|::.|.||.:::|||:|.||.||:.||||:...
  Fly   578 IIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIE 642

Human   842 KLVKIFQEHP----LHGC-----SASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQ 897
            .::.|.:..|    ::.|     ..||:|.:|..: ..|......    |.:|.| ...|.|..:
  Fly   643 NVMVIGKNFPVNQGIYDCVCTPPIGSNASVIDYAK-YNWDSCESY----NGTLVG-GDCGTPPTE 701

Human   898 PNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKL 962
             |..|:|:||.||||.|:..|::|||:.|||..:|:.|.||.|.|||..|...|||: ...||||
  Fly   702 -NVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSL-GVPTQKL 764

Human   963 SVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQ 1027
            .||:....|. ..|||:|.|..||:|:  |..:.::.||:|..|||||:.|||.:|:::||..|:
  Fly   765 EVPNELKPTL-STRGWLIPPFVEKNPW--WSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLK 826

Human  1028 KGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVT 1092
            ||.|:||||.::..:..||::.||||..||||.|:.|.|:|.:.|:..|||:||:...|:|||||
  Fly   827 KGCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVT 891

Human  1093 GLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKK 1157
            .:|:.|.:|:|:::..||..||:.||||:||||||.||.|:||::|:.::.||.|:.||..::::
  Fly   892 HILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDYMFLRQ 956

Human  1158 VRTLRMHLFTALQLLCLALLWAVMS-TAASLAFPFILILTVPLRMVVLTRIFTDREMKCLDANEA 1221
            |...|:||||.:||.||.:||.:.| :..|:.||.:|::.:.:|. .|..:||.||:|.||  :.
  Fly   957 VPIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRK-ALDLVFTRRELKILD--DI 1018

Human  1222 EPVFDEREGVDEYNEM 1237
            .|...:|...|:.:::
  Fly  1019 MPEMTKRAAADDLHKL 1034

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SLC4A2NP_001186621.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..240
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 288..320 9/71 (13%)
ae 324..1240 CDD:273290 369/927 (40%)
Band_3_cyto 359..620 CDD:284893 100/263 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 449..471 3/23 (13%)
HCO3_cotransp 675..1167 CDD:279322 215/500 (43%)
Membrane (anion exchange) 708..1241 220/540 (41%)
Ndae1NP_723263.2 ae 140..1016 CDD:273290 364/905 (40%)
Band_3_cyto 167..435 CDD:284893 104/270 (39%)
HCO3_cotransp 476..968 CDD:279322 217/502 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142082
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1172
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D265068at2759
OrthoFinder 1 1.000 - - FOG0000136
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100185
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1874
SonicParanoid 1 1.000 - - X102
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.680

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