Protein Alignment SLC3A2 and Mal-A1

DIOPT Version :9

• Sequence 1: NP_001012680.1
• Gene: SLC3A2 / 6520
• HGNCID: 11026
• Length: 631
• Species: Homo sapiens
• Sequence 2: NP_476627.3
• Gene: Mal-A1 / 35824
• FlyBaseID: FBgn0002570
• Length: 577
• Species: Drosophila melanogaster
• Alignment Length: 601
• Identity: 126/601 - (20%)
• Similarity: 211/601 - (35%)
• Gaps: 193/601 - (32%)

Human   185 ALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHTGALYRI--GDLQAFQGHGAGNLAGLKG 247
            |.|||..:|::|                   |.:||.:|..|:|  ...:...|.|.|:|.|:..
  Fly     7 ACLLLAIVGFVG-------------------ATEWWESGNYYQIYPRSFRDSDGDGIGDLNGVTE 52

Human   248 RLDYLSSLKVKGLVLGPIHKNQKDDVAQ--TDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDLT 310
            :|.||..:...|..|.||.|:...|...  :|..||.|.:|:.|||:.::..||:..|::|||..
  Fly    53 KLQYLKDIGFTGTWLSPIFKSPMVDFGYDISDFYQIHPEYGTMEDFERMIAKAKEVGIKIILDFV 117

Human   311 PNYRG-ENSWFSTQVDT------------------------------------------------ 326
            ||:.. ||.||:..||:
  Fly   118 PNHSSTENEWFTKSVDSDPVYKDFYIWHDGKINNETGEREPPSNWNSEFRYSAWEWNEVRQQYYL 182

Human   327 ----------------VATKVKDALEFWLQAGVDGFQVRDI------------------------ 351
                            |..::|:.:.|||..||.||::..:
  Fly   183 HQFAIQQADLNYRNPAVVNEMKNVIRFWLGKGVSGFRIDAVPYLFEVDLDRYNQYPDEPLTNDSV 247

Human   352 ----------------ENLKDASSFLAEWQNITKGF-----SEDRLLIAGTNSSDLQQIL----- 390
                            :::.:....:.:|:.:...|     .:.|||:....:| .:.|:
  Fly   248 NCPDPDDHCYTQHIYTQDMPETIDMVYQWRELVDEFHVENGGDKRLLMTEAYTS-FENIMTYYGN 311

Human   391 -----SLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQL 450
                 |.:..|.|.|.:.:..|.:|...||.|..:..........|...:....|:.:.| ..|.
  Fly   312 GVRNGSHIPFNFDFLTSINNASKAGEYVEHIKKWMDAMPEGVYANWVLGNHDNKRVASRF-GVQR 375

Human   451 LRLYQLMLFTLPGTPVFSYGDEIGL---------------------DAAALPGQPMEAPVMLWDE 494
            ..|..::|.||||..|...|:|:|:                     :..|....|..:|.. ||.
  Fly   376 TDLINILLQTLPGHAVTYNGEELGMTDVWISWEDTVDPNACNSDPDNYYARSRDPARSPYQ-WDA 439

Human   495 SSFPDIPGAVSANMTVKGQSED------------PGSLLSLFRRLSDQRSKERSLLHGDFHAFSA 547
            ||   ..|..||:.|....::|            |.|.|.:|::|...| ||.|...|:.:..:.
  Fly   440 SS---KAGFTSADHTWLPVADDYKTNNALQQLRAPRSHLQIFKKLVRVR-KEPSFRQGELNIQAI 500

Human   548 GPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLL---LSTQPGREEGSP 609
            ...:..|.|....::.:::|||.|...     :..||.....|..:|:::   ||:|  ..:|..
  Fly   501 DDDVIIYSRQKTGSDLYVIVLNLGSTS-----KTLDLTKYYELGTQAEVITTSLSSQ--YIDGDV 558

Human   610 LELERLKLEPHEGLLL 625
            ::.......|:.|.:|
  Fly   559 IKSTEFVANPYVGTVL 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC3A2	NP_001012680.1	SLC3A2_N	161..225	CDD:292647	10/39 (26%)
		AmyAc_SLC3A2	208..537	CDD:200483	101/485 (21%)
		AmyA	238..597	CDD:223443	106/513 (21%)
		DUF3459	520..625	CDD:288769	24/107 (22%)
Mal-A1	NP_476627.3	AmyAc_maltase	21..496	CDD:200467	102/481 (21%)
		Alpha-amylase	45..404	CDD:278554	73/360 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1384693at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820