Protein Alignment BMP4 and daw

DIOPT Version :10

• Sequence 1: NP_001334841.1
• Gene: BMP4 / 652
• HGNCID: 1071
• Length: 455
• Species: Homo sapiens
• Sequence 2: NP_523461.1
• Gene: daw / 33474
• FlyBaseID: FBgn0031461
• Length: 586
• Species: Drosophila melanogaster
• Alignment Length: 423
• Identity: 90/423 - (21%)
• Similarity: 161/423 - (38%)
• Gaps: 82/423 - (19%)

Human    75 PET--------GKKKVA-EIQGHAGG---RRSGQSHELLRDFEATLLQ--------MFGLRRRPQ 119
            |||        |::.:. .::..|||   ..|.:..|.:.:.:.|.|:        :..||.:..
  Fly   204 PETPIEPELPLGERNITISVKSSAGGCPKCESNRQVEHITEEQLTHLRIEFVKQQILEKLRLKES 268

Human   120 PSKSAV-IPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSF----HHEEHLENIPGT 179
            |..||| :|..:.|...|...::..:.        .|.....|.|.:.|    ..|.........
  Fly   269 PKVSAVELPKPIFDGMTLSHPDDSTKN--------KELDDYYARTSKKFILLNREEVECNRARDG 325

Human   180 SENSAFRFLFNLSSI-PENEVISSAELRLFREQVDQGPDWERGFHRINIYEVMKPPAE---VVPG 240
            ..|.:..|.|.:... .|...:|:|.|.||:.:.          :|.:...|....|:   ||..
  Fly   326 KSNPSMCFTFKIDDADAEGFDVSTAVLWLFKNKQ----------NRTDTASVNSTSAQQTIVVSE 380

Human   241 HLITRLLDTRLVHHNVT----------RWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQ 295
            ..:.:..|::.:....|          .|...|:...:..|..        ..|::||.|. |..
  Fly   381 VEVDQQKDSKYLSAAKTIAIQSVNVQDEWMKIDIEWPIKHWIS--------GHELSHLIQI-TCG 436

Human   296 GQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSL 360
            |..|.....:.....::   ||.:|          :..:.|.::|.:..|.........|.|..|
  Fly   437 GCDVSDMEEIISVDKDY---RPFIV----------IDMQNRRRKSRQKRSINCSSGMTECCREHL 488

Human   361 YVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNS--VNSSIPKA-CCVP 422
            |:.|.|:||::||:.|.||.|::|.|.|....:....:::|:.:..::::  .|.|:... ||..
  Fly   489 YISFRDIGWSNWILKPEGYNAYFCRGSCSSVASVTQAASHHSSIMKILSTSGANKSLELVPCCTA 553

Human   423 TELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 455
            .:.|::.::.:|..:...:|....||||.||||
  Fly   554 KQYSSLQLVVMDSSNTATVKTLPNMVVESCGCR 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMP4	NP_001334841.1	TGFb_propeptide	90..322	CDD:459906	49/261 (19%)
		TGF_beta_BMP4_BMP2B	349..455	CDD:381661	31/108 (29%)
daw	NP_523461.1	TGF_beta_INHB	483..585	CDD:381630	30/101 (30%)