DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC2A4 and sut2

DIOPT Version :9

Sequence 1:	NP_001033.1	Gene:	SLC2A4 / 6517	HGNCID:	11009	Length:	509	Species:	Homo sapiens
Sequence 2:	NP_524732.1	Gene:	sut2 / 44269	FlyBaseID:	FBgn0028562	Length:	491	Species:	Drosophila melanogaster

Alignment Length:	472	Identity:	165/472 - (34%)
Similarity:	246/472 - (52%)	Gaps:	19/472 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    15 PPQQRVTG---TLVLAVFSAVLG-SLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSSIPPG 75
            ||  :|.|   .|:|...:..|| ::..||..||:|||.::|::...:....    |..:.:..|
  Fly     9 PP--KVNGWTPLLMLICLTVTLGTTIPVGYFFGVLNAPAEIIKKWCQDILAN----EYDTIVTAG 67

Human    76 TLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLIL 140
            .|..||...|:|:.:||:..|....::....|||..:::::||.|:.|.|.....||.|.|||:.
  Fly    68 QLDILWTSIVSIYLIGGICGSCFSAVLCDKYGRKGCLVISSVLFVVSGILFTWCRAAKSLEMLMT 132

Human   141 GRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWPLL 205
            ||||.|..|.|.....|||:.|.||:.|.|::|....:.:..|||:|||..|..|||:..|||..
  Fly   133 GRFLGGIASALIFTAQPMYLLESAPSELSGSVGVFTCIGVTGGILLAQVATLSHLLGSERLWPYA 197

Human   206 LGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKLERE 270
            |....|..:..||||.:.|||||:||:.:.....:.|:|.||.|......|..||.:.|..||.:
  Fly   198 LSFYSLLVMASLVLLWWFPESPRWLYLHKRDSAASEKALLRLRGRNTEEEVHQELLEMKATLEAK 262

Human   271 ---RPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGV--GQPAYATIGAG 330
               ...||..:|.:.....||::....|.:||||||||:|:||.||...||.  |...:..:|.|
  Fly   263 SSSEVSSLCSVLRNSELWLPLLLVCSFQATQQLSGINAIFFYSLSILTNAGFSDGAATWLNLGIG 327

Human   331 VVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAIL-MTVALLLLERVPA--MSYVSIVAIFGFV 392
            ..|...:|:..||:.|..||.|.::. ..||..|:| |::.|..|||..:  ::|.....|..|:
  Fly   328 SFNLCTSLLGPLLIRRFPRRPLMMIS-CSMCALALLAMSLGLFFLERSESTVLTYFCAAFILTFI 391

Human   393 AFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLL 457
            ..|::|.|||.:||.:||....|||.||::....:|..||::||.|..:......:.|:....:.
  Fly   392 LGFQLGLGPIAYFIGSELLEDSPRPVAMSMGSLFSWIGNFLVGMCFPLLQSVWSSFAFIPCMCVC 456

Human   458 LGFFIFTFLRVPETRGR 474
            :...:.|:..:||||||
  Fly   457 IYCLLLTWRYLPETRGR 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC2A4	NP_001033.1	Interaction with SRFBP1. /evidence=ECO:0000269\|PubMed:16647043	7..13
		Sugar_tr	27..483	CDD:306568	159/457 (35%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		5/5 (100%)
		Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:8300557	489..490
sut2	NP_524732.1	Sugar_tr	23..473	CDD:278511	157/454 (35%)
sut2	NP_524732.1	MFS	76..466	CDD:119392	138/390 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144215
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	0.197	Inparanoid score	I2535
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.900