DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC2A4 and CG1213

DIOPT Version :9

Sequence 1:	NP_001033.1	Gene:	SLC2A4 / 6517	HGNCID:	11009	Length:	509	Species:	Homo sapiens
Sequence 2:	NP_001246937.1	Gene:	CG1213 / 40728	FlyBaseID:	FBgn0037387	Length:	491	Species:	Drosophila melanogaster

Alignment Length:	488	Identity:	144/488 - (29%)
Similarity:	226/488 - (46%)	Gaps:	63/488 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    16 PQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGP--------EGPSSI 72
            |:...:|.:.:|..:|.|.:...|..:|                |....||        :.|.|.
  Fly    34 PEPVKSGRIFMAAVAANLSAFVVGTTLG----------------WTSPIGPKLKSEDTSDSPLSR 82

Human    73 PPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEM 137
            |..:....|..|  :.:||.:::.|:.|.::..:|||..:|.:::..||.   .||...|:...:
  Fly    83 PITSDEDAWISS--LIAVGALVAPFVAGPMADRIGRKWVLLSSSLFFVLA---FGLNMVASEVWI 142

Human   138 LILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLW 202
            |.:.|.:.|...|....:.|||||||:..::|||.|:|.||.||.|||....:| ..:...|..|
  Fly   143 LYMSRLIQGFGVGFVMTVQPMYVGEISTDNVRGATGSLMQLFIVGGILYVYAIG-PYVSYQALQW 206

Human   203 PLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKL 267
            ..:    |:|.:..||.. ..|||| |.:..:..:..|.|||:.|.| ....||..|:.:.:..:
  Fly   207 CCI----VVPVVFDLVFY-MMPESP-YFFAGKGRKSEALKSLQFLRG-QSAEGVHDEMAEIQANV 264

Human   268 ERERPL--SLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGVG-QPAYATIGA 329
            |.....  :::.|..:..:|:.|.|...|...|||||||.|.:.|.|||.:|..| .||.|||..
  Fly   265 EEAMASKGTVMDLFKNAGNRRALFICAGLISFQQLSGINVVLFNSQSIFASANTGLDPAIATIII 329

Human   330 GVVNTVFTLVSVLLVERAGRRTLHL-------LGLAGMCGCAILM-----TVALLLLERVPAMSY 382
            |.|....:.::.|:.:|.||:.:.|       :|||.: |....|     .::.::...|||:..
  Fly   330 GCVQVGSSALTPLVADRLGRKVMLLTSSSVMSIGLAAL-GAFFYMQLVKGDISSVVWMPVPALII 393

Human   383 VSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGP 447
            .:||...||        ||:||.::.|:|....:..|.:|...:.||..|::.. |....:|:|.
  Fly   394 YNIVYCTGF--------GPLPWAVLGEMFPANIKSVASSVVASTCWTLGFLVTF-FYPSLDALGS 449

Human   448 -YVFLLFAVLLLGFFIFTFLRVPETRGRTFDQI 479
             |.|.||||.::..|.|....|.||:|.:..||
  Fly   450 YYAFWLFAVCMVVAFFFVLFVVMETKGLSLQQI 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC2A4	NP_001033.1	Interaction with SRFBP1. /evidence=ECO:0000269\|PubMed:16647043	7..13
		Sugar_tr	27..483	CDD:306568	142/477 (30%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		5/5 (100%)
		Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:8300557	489..490
CG1213	NP_001246937.1	SP	42..482	CDD:273317	140/478 (29%)
CG1213	NP_001246937.1	MFS	47..460	CDD:119392	133/451 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810