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Protein Alignment SLC2A4 and CG8249

DIOPT Version :10

Sequence 1:	NP_001033.1	Gene:	SLC2A4 / 6517	HGNCID:	11009	Length:	509	Species:	Homo sapiens
Sequence 2:	NP_611060.2	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	520	Identity:	142/520 - (27%)
Similarity:	235/520 - (45%)	Gaps:	82/520 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    15 PP--QQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSSIPPGTL 77
            ||  |.|.....|:||..|.:|....|..:.:   |...:.|..:.|          ..:.....
  Fly    34 PPGEQTRAVRRQVIAVILANVGVFSTGMTLAM---PTATLHQLKDTT----------EPVHLNDS 85

Human    78 TTLWALSVAIFS--VGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAA---ASYEM 137
            ...|..||...|  :||::|.||:..|    |||::::|.|||.:|...|:...:.:   |.:..
  Fly    86 QASWFASVNALSAPIGGLLSGFLLDRI----GRKKSLIVLNVLIILAWILLATPSESDQNAFFWQ 146

Human   138 LILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLW 202
            ||:.||::|...||.|....:|..||:....||:|        ::|..|:...|:..|.|
  Fly   147 LIVSRFMLGVGMGLASAPPGVYAAEISVPKTRGSL--------ILGTSISVAGGITILYG----- 198

Human   203 PLLLGLTV-----LPALL----QLVLLPFC----PESPRYLYIIQNLEGPARKSLKRLTGWADVS 254
               :|..:     |.||:    |||.| .|    |||..:| :.:.....|::||....|:....
  Fly   199 ---IGYCIRDDFRLIALICCGYQLVAL-LCVLPLPESHCWL-LSKKRVTEAKRSLNYFRGFNKSD 258

Human   255 -----GVLAELKDEKRKLERERPLSLLQLLGSRTHR----QPLIIAVVLQLSQQLSGINAVFYYS 310
                 .||.|.:..::.|: :|..::.:......|.    :||:|.:.|...|||:||..|..::
  Fly   259 EITHPQVLEEFQLLQKSLQ-QRNTAVKESFWRNLHEPEVYKPLVILMSLFAFQQLTGIFVVIVFA 322

Human   311 TSIFETAGVG-QPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMT--VALL 372
            ..|.:.||:. .|....:..|:...:.|.....::|..|||...::...||..|..|:.  ..:.
  Fly   323 VQISQEAGIEIDPFMCAVLIGLARLITTCPMGYILEWWGRRRAGIISTLGMSVCMFLLAGHSQIE 387

Human   373 LLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPR-PAA---MAVAGFSNWTSNFI 433
            :|:.||   |:.:|||.||:....:|...:|:|:::|||.|..| ||:   :||..|    .:|:
  Fly   388 ILKEVP---YLPVVAIVGFIVLSTLGLYTLPFFMISELFPQKVRGPASGLTVAVGMF----ISFV 445

Human   434 IGMGFQYVAEAMG-PYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISAAFH--RTPSLLEQEVK 495
            :...:..:.|.:| ...|::|.|:.|...||.:|.:||||.||..:|...|.  |:.|..:.:|:
  Fly   446 VLKTYPGIKEYLGMSNCFIIFGVMALFALIFVYLALPETRRRTLLEIEEQFRSGRSKSQNQADVE 510

Human 496 495
Fly 511 510

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.