Protein Alignment SLC2A4 and CG32054

DIOPT Version :10

• Sequence 1: NP_001033.1
• Gene: SLC2A4 / 6517
• HGNCID: 11009
• Length: 509
• Species: Homo sapiens
• Sequence 2: NP_729588.1
• Gene: CG32054 / 326185
• FlyBaseID: FBgn0052054
• Length: 563
• Species: Drosophila melanogaster
• Alignment Length: 582
• Identity: 130/582 - (22%)
• Similarity: 214/582 - (36%)
• Gaps: 163/582 - (28%)

Human     3 SGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGY---------NIGV------INAPQKVI 52
            ||:.|.|.....||.|        ..||......|.||         ..|:      .|.||:.|
  Fly    48 SGYPQPGHSWNPPPPQ--------FGFSGYPPPPQQGYPPQFYGPPPGYGLPQATLPPNPPQQTI 104

Human    53 EQSYNETWLGRQGPEGPSS---------IPPGTLTTLWAL-------------SVAIFSVGGMIS 95
              :.|.:|..|.....|.|         ...|.:...|::             :.|.:.:||:|.
  Fly   105 --TVNNSWYSRNQKNKPQSNAVGAAGLIFVSGGMNIAWSIGFRGVLHYKTTEHNFAAWFIGGIIG 167

Human    96 SFLIGIISQWLGRKRAMLVNNVLAVLGGSL------MGLANAAASYEMLILGRFLIGAYSGLTSG 154
            :.:...:...:.:|..::.::.|.::||.|      .|.|..||||        |.|..:||...
  Fly   168 AVISWFLINNVAKKYVLIFSSFLVMIGGILTTSTKNSGDATLAASY--------LDGIANGLVFA 224

Human   155 LVPMYVGEIAPTHLRGAL-GTLNQLAIVIGILIAQVL----------------GLESLLGTASLW 202
            ......||::.:::||.: .::.|:...:||.: |::                ..|::.|..|:.
  Fly   225 PFMALAGEVSVSYMRGMVSASIEQMCFGLGIFL-QIIYTSTWNSTAYPSYNSFSAENMKGVLSII 288

Human   203 PLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRL-TGWADVSGVLAELKDEKRK 266
            ...|.| ::.:||       |.|||..:....|.|..|..:|:|| ..:...:....:|.:.|:.
  Fly   289 YGFLAL-IIGSLL-------CIESPVIMLAKNNDEQGAIDALRRLQRPYTLTNETFEQLAEHKKY 345

Human   267 LERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAV---------FYYSTSIFETAGVGQP 322
            |.:.:.||:.|.:|...   |..|.:|.     |.|:||:         |.||.:  ...|...|
  Fly   346 LAQNKELSMGQSIGQAL---PTFIRLVF-----LRGLNAMSISKFVMIGFVYSFA--SPYGYVSP 400

Human   323 AYA-TIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIV 386
            :.. .||.||...:...::...:|..||:...||||. :|.                .||:|
  Fly   401 SVGWFIGFGVCRWMGNFIATFCMESCGRKKPTLLGLI-VCS----------------VMSFV--- 445

Human   387 AIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTS---------NFIIGMGFQYVA 442
             :.|....|....|.....:|.|||      |.:|....|.:.|         :||   .|.::.
  Fly   446 -VAGQFNIFTYNTGNNIMLLVFELF------AGIAFTATSPYLSEAFPLEVKQHFI---SFTFIG 500

Human   443 EAM---------------GPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISAAFHRTPSL 489
            |.:               ..|.:::..:.|.||| |..:.:||||..|..:....|.:..|:
  Fly   501 EMLVFLVLTLIRWSSSGGANYFYVMGGLYLFGFF-FGLVCLPETRRTTLREAQDKFSKFISM 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC2A4	NP_001033.1	Interaction with SRFBP1. /evidence=ECO:0000269|PubMed:16647043	7..13		2/5 (40%)
		MFS_GLUT_Class1	26..474	CDD:340989	120/542 (22%)
		Dileucine internalization motif. /evidence=ECO:0000269|PubMed:8300557	489..490		0/1 (0%)
CG32054	NP_729588.1	Pro-rich	<7..102	CDD:464580	15/61 (25%)
		MFS	157..555	CDD:475125	104/455 (23%)