Protein Alignment SLC2A4 and CG42826

DIOPT Version :10

• Sequence 1: NP_001033.1
• Gene: SLC2A4 / 6517
• HGNCID: 11009
• Length: 509
• Species: Homo sapiens
• Sequence 2: NP_001189079.1
• Gene: CG42826 / 10178905
• FlyBaseID: FBgn0262008
• Length: 473
• Species: Drosophila melanogaster
• Alignment Length: 526
• Identity: 123/526 - (23%)
• Similarity: 211/526 - (40%)
• Gaps: 119/526 - (22%)

Human    14 EPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSS--IPPGT 76
            |||.:....|...|.|      |:.|:.    |..|          |...    |.:|  :..|.
  Fly     7 EPPPEDSLATTEKATF------LRLGHK----NHSQ----------WTAL----GSASFILISGG 47

Human    77 LTTLWALSVAIFS---------------------VGGMISSFLIGIISQWLGRKRAMLVNNVLAV 120
            ::..|....|:.|                     :|.:..:|    .:..|.::...:.:::|.:
  Fly    48 MSLAWGAGFAVHSAHRDQLLRTVHMQIAWYATAVLGALFGAF----YTHRLPQQPIYIFSSILVI 108

Human   121 LGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMY--VGEIAPTHLRGAL-GTLNQLAIVI 182
            ..|.|. ||..... ..:|..|:|.|..:||.  .||..  ||||:...:||.| .|:.||:...
  Fly   109 ASGILF-LAWPECP-GAIIAARYLDGLANGLV--FVPALSTVGEISVNEIRGLLASTVEQLSFNT 169

Human   183 GILIAQVLGLESLLGTASLWPL----------LLG-LTVLPALLQLVL-LPFCPESPRYLYIIQN 235
            |||:       .|:.|| :|.:          :.| |:::..::.|.| |..|.|||.:| ::::
  Fly   170 GILL-------QLIYTA-VWQVDWNVAIVADQVHGVLSIVYGVIALALALTLCVESPVHL-LMRS 225

Human   236 LEGPARKSLKRL-TGWADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHR-QPLIIAVV-LQLS 297
            .|..|..:|:.| ..:...|.:|..|.:.|:.:...|.:    .|||...: .|.::.:: |:|.
  Fly   226 SEQRALVALRHLQRPYMVTSEMLLRLDEHKQYVADNREM----CLGSSLQKGYPSVLKLLALRLL 286

Human   298 QQLSGINAVFYYSTSIFETAGVGQP------AYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLG 356
            ..|| :|::.  .::::||   |..      |:..:..|::.......:|||::..||:...|.|
  Fly   287 GVLS-LNSII--CSALYET---GNQLVSCLYAWPFVVFGLLRWGGCFFAVLLMDTTGRKKPTLFG 345

Human   357 LAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFI-VAELFSQGPRPAAM 420
            :......||...   .|..|.|.| ..::|.:|. :.||| |.|.....: :.|.|....:|..:
  Fly   346 IFSTGAFAIAYA---NLFGRTPHM-ITALVMLFS-LQFFE-GLGQCASAVYLTEGFPLLMKPHMV 404

Human   421 AVAGFSNWTSNFIIGMGFQYVAE------AMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQI 479
            ||.......:..::......:||      :||....:.|   |||.|.     :||||..|..:.
  Fly   405 AVVYIMEQAARLLLCSFLPSIAEITAYFHSMGALSMVCF---LLGIFC-----LPETRLVTLAEA 461

Human   480 SAAFHR 485
            ...|.:
  Fly   462 QLKFSK 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC2A4	NP_001033.1	Interaction with SRFBP1. /evidence=ECO:0000269|PubMed:16647043	7..13
		MFS_GLUT_Class1	26..474	CDD:340989	117/501 (23%)
		Dileucine internalization motif. /evidence=ECO:0000269|PubMed:8300557	489..490
CG42826	NP_001189079.1	MFS	35..460	CDD:475125	111/469 (24%)